The Resting‐State Activities of the Angular Gyrus and the Micturition Desire‐Awakening Function in Children With and Without Enuresis
ABSTRACT Background Micturition desire‐awakening (MDA) function plays a pivotal role in the development of primary nocturnal enuresis (PNE); however, its neural correlates remain largely unexplored. Consequently, this study aimed to identify specific brain regional activities associated with MDA fun...
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| Format: | Article |
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Wiley
2024-12-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70177 |
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| author | Xindi Lin Shaogen Zhong Mengxing Wang Yi Mao Yuhan Wu Jiayi Lu Wei Zhong Di Wu Jun Ma |
| author_facet | Xindi Lin Shaogen Zhong Mengxing Wang Yi Mao Yuhan Wu Jiayi Lu Wei Zhong Di Wu Jun Ma |
| author_sort | Xindi Lin |
| collection | DOAJ |
| description | ABSTRACT Background Micturition desire‐awakening (MDA) function plays a pivotal role in the development of primary nocturnal enuresis (PNE); however, its neural correlates remain largely unexplored. Consequently, this study aimed to identify specific brain regional activities associated with MDA function. Methods Neuroimaging data were collected from 173 children with varying MDA functional grade scores at the Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, from July 2018 to November 2022. Resting‐state images were analyzed using whole‐brain correlation techniques and AlphaSim correction to identify brain regional activities and resting‐state functional connectivity (RSFC) associated with MDA functional grade scores. Results Whole‐brain correlation analysis demonstrated that the fractional amplitude of low‐frequency fluctuations in the right angular gyrus (AG) exhibited a negative correlation with MDA functional grade scores (rs = −0.336, p < 0.001), indicating reduced neural activity in this region with MDA dysfunction. Conversely, RSFC between the right middle frontal gyrus and the right AG was positively correlated with MDA functional grade scores (rs = 0.274, p < 0.001), suggesting increased connectivity in these areas associated with worse MDA functionality. Conclusion These findings provide preliminary insights into the neural underpinnings of MDA functionality. |
| format | Article |
| id | doaj-art-ab2f3f6d122b47bc810a49fc45ceb11a |
| institution | DOAJ |
| issn | 2162-3279 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
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| series | Brain and Behavior |
| spelling | doaj-art-ab2f3f6d122b47bc810a49fc45ceb11a2025-08-20T02:55:58ZengWileyBrain and Behavior2162-32792024-12-011412n/an/a10.1002/brb3.70177The Resting‐State Activities of the Angular Gyrus and the Micturition Desire‐Awakening Function in Children With and Without EnuresisXindi Lin0Shaogen Zhong1Mengxing Wang2Yi Mao3Yuhan Wu4Jiayi Lu5Wei Zhong6Di Wu7Jun Ma8Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of MedicineShanghai Jiao Tong UniversityShanghai ChinaDepartment of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of MedicineShanghai Jiao Tong UniversityShanghai ChinaCollege of Medical ImagingShanghai University of Medicine and Health SciencesShanghaiChinaDepartment of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of MedicineShanghai Jiao Tong UniversityShanghai ChinaDepartment of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of MedicineShanghai Jiao Tong UniversityShanghai ChinaDepartment of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of MedicineShanghai Jiao Tong UniversityShanghai ChinaDepartment of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of MedicineShanghai Jiao Tong UniversityShanghai ChinaDepartment of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of MedicineShanghai Jiao Tong UniversityShanghai ChinaDepartment of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of MedicineShanghai Jiao Tong UniversityShanghai ChinaABSTRACT Background Micturition desire‐awakening (MDA) function plays a pivotal role in the development of primary nocturnal enuresis (PNE); however, its neural correlates remain largely unexplored. Consequently, this study aimed to identify specific brain regional activities associated with MDA function. Methods Neuroimaging data were collected from 173 children with varying MDA functional grade scores at the Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, from July 2018 to November 2022. Resting‐state images were analyzed using whole‐brain correlation techniques and AlphaSim correction to identify brain regional activities and resting‐state functional connectivity (RSFC) associated with MDA functional grade scores. Results Whole‐brain correlation analysis demonstrated that the fractional amplitude of low‐frequency fluctuations in the right angular gyrus (AG) exhibited a negative correlation with MDA functional grade scores (rs = −0.336, p < 0.001), indicating reduced neural activity in this region with MDA dysfunction. Conversely, RSFC between the right middle frontal gyrus and the right AG was positively correlated with MDA functional grade scores (rs = 0.274, p < 0.001), suggesting increased connectivity in these areas associated with worse MDA functionality. Conclusion These findings provide preliminary insights into the neural underpinnings of MDA functionality.https://doi.org/10.1002/brb3.70177angular gyrusmicturition desire‐awakening functionprimary nocturnal enuresisfractional amplitude of low‐frequency fluctuation (fALFF)resting‐state functional connectivity (RSFC) |
| spellingShingle | Xindi Lin Shaogen Zhong Mengxing Wang Yi Mao Yuhan Wu Jiayi Lu Wei Zhong Di Wu Jun Ma The Resting‐State Activities of the Angular Gyrus and the Micturition Desire‐Awakening Function in Children With and Without Enuresis Brain and Behavior angular gyrus micturition desire‐awakening function primary nocturnal enuresis fractional amplitude of low‐frequency fluctuation (fALFF) resting‐state functional connectivity (RSFC) |
| title | The Resting‐State Activities of the Angular Gyrus and the Micturition Desire‐Awakening Function in Children With and Without Enuresis |
| title_full | The Resting‐State Activities of the Angular Gyrus and the Micturition Desire‐Awakening Function in Children With and Without Enuresis |
| title_fullStr | The Resting‐State Activities of the Angular Gyrus and the Micturition Desire‐Awakening Function in Children With and Without Enuresis |
| title_full_unstemmed | The Resting‐State Activities of the Angular Gyrus and the Micturition Desire‐Awakening Function in Children With and Without Enuresis |
| title_short | The Resting‐State Activities of the Angular Gyrus and the Micturition Desire‐Awakening Function in Children With and Without Enuresis |
| title_sort | resting state activities of the angular gyrus and the micturition desire awakening function in children with and without enuresis |
| topic | angular gyrus micturition desire‐awakening function primary nocturnal enuresis fractional amplitude of low‐frequency fluctuation (fALFF) resting‐state functional connectivity (RSFC) |
| url | https://doi.org/10.1002/brb3.70177 |
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