Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men
The purpose of the present study was to investigate multiple anthropometric parameters used to evaluate obesity, particularly visceral abdominal fat area, and various metabolic parameters including malondialdehyde (MDA) as an oxidative stress marker. We evaluated various measures of obesity, includi...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/524291 |
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| author | Sun Min Lee Young Hye Cho Sang Yeoup Lee Dong Wook Jeong A Ra Cho Jeong Suk Jeon Eun-Ju Park Yun Jin Kim Jeong Gyu Lee Yu Hyeon Yi Young Jin Tak Hye Rim Hwang Seung-Hun Lee Junehee Han |
| author_facet | Sun Min Lee Young Hye Cho Sang Yeoup Lee Dong Wook Jeong A Ra Cho Jeong Suk Jeon Eun-Ju Park Yun Jin Kim Jeong Gyu Lee Yu Hyeon Yi Young Jin Tak Hye Rim Hwang Seung-Hun Lee Junehee Han |
| author_sort | Sun Min Lee |
| collection | DOAJ |
| description | The purpose of the present study was to investigate multiple anthropometric parameters used to evaluate obesity, particularly visceral abdominal fat area, and various metabolic parameters including malondialdehyde (MDA) as an oxidative stress marker. We evaluated various measures of obesity, including body mass index (BMI), waist circumference (WC), sagittal abdominal diameter, fat percentages using dual-energy X-ray absorptiometry, visceral fat area (VFA), subcutaneous fat area, multiple biomarkers related to metabolic disease, and urinary MDA, in 73 asymptomatic middle-aged men who were not severely obese. We examined relationships between multiple measures of obesity, metabolic markers, and urinary MDA levels and evaluated associations between VFA and urinary MDA. In the visceral obesity group, γ-glutamyl transferase (GGT), uric acid, and urinary MDA levels were significantly higher than in the nonvisceral obesity group (P = 0.008, P = 0.002, and P = 0.018). Urinary MDA (r = 0.357, P = 0.002) and uric acid (r = 0.263, P = 0.027) levels were only significantly positively correlated with VFA among measures of obesity. Urinary MDA, serum GGT, and serum CRP were significantly positively associated with VFA (P = 0.001, P = 0.046, and P = 0.023, resp.), even after adjusting for BMI and WC. |
| format | Article |
| id | doaj-art-ab2e7f37b1504b68990b8b6807670e99 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ab2e7f37b1504b68990b8b6807670e992025-08-20T02:20:12ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/524291524291Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged MenSun Min Lee0Young Hye Cho1Sang Yeoup Lee2Dong Wook Jeong3A Ra Cho4Jeong Suk Jeon5Eun-Ju Park6Yun Jin Kim7Jeong Gyu Lee8Yu Hyeon Yi9Young Jin Tak10Hye Rim Hwang11Seung-Hun Lee12Junehee Han13Department of Laboratory Medicine and Molecular Genetics and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of KoreaFamily Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of KoreaFamily Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of KoreaFamily Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of KoreaFamily Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of KoreaFamily Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of KoreaFamily Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of KoreaDepartment of Family Medicine, Pusan National University Hospital, Busan 49241, Republic of KoreaDepartment of Family Medicine, Pusan National University Hospital, Busan 49241, Republic of KoreaDepartment of Family Medicine, Pusan National University Hospital, Busan 49241, Republic of KoreaDepartment of Family Medicine, Pusan National University Hospital, Busan 49241, Republic of KoreaDepartment of Family Medicine, Pusan National University Hospital, Busan 49241, Republic of KoreaDepartment of Family Medicine, Pusan National University Hospital, Busan 49241, Republic of KoreaResearch And Statistical Support, Research Institute of Convergence for Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of KoreaThe purpose of the present study was to investigate multiple anthropometric parameters used to evaluate obesity, particularly visceral abdominal fat area, and various metabolic parameters including malondialdehyde (MDA) as an oxidative stress marker. We evaluated various measures of obesity, including body mass index (BMI), waist circumference (WC), sagittal abdominal diameter, fat percentages using dual-energy X-ray absorptiometry, visceral fat area (VFA), subcutaneous fat area, multiple biomarkers related to metabolic disease, and urinary MDA, in 73 asymptomatic middle-aged men who were not severely obese. We examined relationships between multiple measures of obesity, metabolic markers, and urinary MDA levels and evaluated associations between VFA and urinary MDA. In the visceral obesity group, γ-glutamyl transferase (GGT), uric acid, and urinary MDA levels were significantly higher than in the nonvisceral obesity group (P = 0.008, P = 0.002, and P = 0.018). Urinary MDA (r = 0.357, P = 0.002) and uric acid (r = 0.263, P = 0.027) levels were only significantly positively correlated with VFA among measures of obesity. Urinary MDA, serum GGT, and serum CRP were significantly positively associated with VFA (P = 0.001, P = 0.046, and P = 0.023, resp.), even after adjusting for BMI and WC.http://dx.doi.org/10.1155/2015/524291 |
| spellingShingle | Sun Min Lee Young Hye Cho Sang Yeoup Lee Dong Wook Jeong A Ra Cho Jeong Suk Jeon Eun-Ju Park Yun Jin Kim Jeong Gyu Lee Yu Hyeon Yi Young Jin Tak Hye Rim Hwang Seung-Hun Lee Junehee Han Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men Mediators of Inflammation |
| title | Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men |
| title_full | Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men |
| title_fullStr | Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men |
| title_full_unstemmed | Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men |
| title_short | Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men |
| title_sort | urinary malondialdehyde is associated with visceral abdominal obesity in middle aged men |
| url | http://dx.doi.org/10.1155/2015/524291 |
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