Cannabinoid overrides triggers of GABAergic plasticity in vestibular circuits and distorts the development of navigation

Cannabinoid overrides triggers of GABAergic plasticity in vestibular circuits and distorts the development of navigation

Summary: Early life exposure to cannabis can result in long-lasting deficits in spatial navigation. We ask if the development of this behavior is subject to early life activity of type I cannabinoid receptor (CB1R) in the vestibular nucleus. In rodents, we found that local exposure to CB1R agonist w...

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Main Authors: Wei Shi, Kenneth Lap-Kei Wu, Mengliu Yang, Francisco Paulo De Nogueira Botelho, Oscar Wing-Ho Chua, Hui-Jing Hu, Ka-Pak Ng, Ulysses Tsz-Fung Lam, Kin-Wai Tam, Chun-Wai Ma, Daisy Kwok-Yan Shum, Ying-Shing Chan
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225008272
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