Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease
A newborn male presented with watery diarrhea, dehydration and metabolic acidosis. Severe secretory diarrhea of variable magnitude persisted when the patient was on parenteral nutrition with no oral intake. Initial light microscopic evaluation of a small intestinal mucosal biopsy showed partial vill...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2001-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2001/743925 |
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| _version_ | 1832555874749513728 |
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| author | Wendy Wilson R Brent Scott Alfredo Pinto Marli A Robertson |
| author_facet | Wendy Wilson R Brent Scott Alfredo Pinto Marli A Robertson |
| author_sort | Wendy Wilson |
| collection | DOAJ |
| description | A newborn male presented with watery diarrhea, dehydration and metabolic acidosis. Severe secretory diarrhea of variable magnitude persisted when the patient was on parenteral nutrition with no oral intake. Initial light microscopic evaluation of a small intestinal mucosal biopsy showed partial villous atrophy and crypt hypoplasia. Ultrastructural studies of the villous enterocyte revealed internalized inclusions of microvilli, typical of microvillous inclusion disease. Presented are a case report and a discussion of the differential diagnosis of watery diarrhea in the neonate, as well as a short review of microvillous inclusion disease. |
| format | Article |
| id | doaj-art-ab2aa3895e7c4baabdfca6643532e006 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-ab2aa3895e7c4baabdfca6643532e0062025-02-03T05:47:01ZengWileyCanadian Journal of Gastroenterology0835-79002001-01-01151616410.1155/2001/743925Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion DiseaseWendy Wilson0R Brent Scott1Alfredo Pinto2Marli A Robertson3Department of Pediatrics, University of Calgary, Calgary, Alberta, CanadaDepartment of Pediatrics, University of Calgary, Calgary, Alberta, CanadaDepartment of Pathology, University of Calgary, Calgary, Alberta, CanadaDepartment of Pediatrics, University of Calgary, Calgary, Alberta, CanadaA newborn male presented with watery diarrhea, dehydration and metabolic acidosis. Severe secretory diarrhea of variable magnitude persisted when the patient was on parenteral nutrition with no oral intake. Initial light microscopic evaluation of a small intestinal mucosal biopsy showed partial villous atrophy and crypt hypoplasia. Ultrastructural studies of the villous enterocyte revealed internalized inclusions of microvilli, typical of microvillous inclusion disease. Presented are a case report and a discussion of the differential diagnosis of watery diarrhea in the neonate, as well as a short review of microvillous inclusion disease.http://dx.doi.org/10.1155/2001/743925 |
| spellingShingle | Wendy Wilson R Brent Scott Alfredo Pinto Marli A Robertson Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease Canadian Journal of Gastroenterology |
| title | Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease |
| title_full | Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease |
| title_fullStr | Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease |
| title_full_unstemmed | Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease |
| title_short | Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease |
| title_sort | intractable diarrhea in a newborn infant microvillous inclusion disease |
| url | http://dx.doi.org/10.1155/2001/743925 |
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