Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats
Spinal cord injury (SCI) often results in death of spinal neurons and atrophy of muscles which they govern. Thus, following SCI, reorganizing the lumbar spinal sensorimotor pathways is crucial to alleviate muscle atrophy. Tail nerve electrical stimulation (TANES) has been shown to activate the centr...
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/7351238 |
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| author | Yu-Ting Zhang Hui Jin Jun-Hua Wang Lan-Yu Wen Yang Yang Jing-Wen Ruan Shu-Xin Zhang Eng-Ang Ling Ying Ding Yuan-Shan Zeng |
| author_facet | Yu-Ting Zhang Hui Jin Jun-Hua Wang Lan-Yu Wen Yang Yang Jing-Wen Ruan Shu-Xin Zhang Eng-Ang Ling Ying Ding Yuan-Shan Zeng |
| author_sort | Yu-Ting Zhang |
| collection | DOAJ |
| description | Spinal cord injury (SCI) often results in death of spinal neurons and atrophy of muscles which they govern. Thus, following SCI, reorganizing the lumbar spinal sensorimotor pathways is crucial to alleviate muscle atrophy. Tail nerve electrical stimulation (TANES) has been shown to activate the central pattern generator (CPG) and improve the locomotion recovery of spinal contused rats. Electroacupuncture (EA) is a traditional Chinese medical practice which has been proven to have a neural protective effect. Here, we examined the effects of TANES and EA on lumbar motor neurons and hindlimb muscle in spinal transected rats, respectively. From the third day postsurgery, rats in the TANES group were treated 5 times a week and those in the EA group were treated once every other day. Four weeks later, both TANES and EA showed a significant impact in promoting survival of lumbar motor neurons and expression of choline acetyltransferase (ChAT) and ameliorating atrophy of hindlimb muscle after SCI. Meanwhile, the expression of neurotrophin-3 (NT-3) in the same spinal cord segment was significantly increased. These findings suggest that TANES and EA can augment the expression of NT-3 in the lumbar spinal cord that appears to protect the motor neurons as well as alleviate muscle atrophy. |
| format | Article |
| id | doaj-art-ab28e60afe614393a10fd4d18d31bcb2 |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-ab28e60afe614393a10fd4d18d31bcb22025-08-20T02:20:12ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/73512387351238Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in RatsYu-Ting Zhang0Hui Jin1Jun-Hua Wang2Lan-Yu Wen3Yang Yang4Jing-Wen Ruan5Shu-Xin Zhang6Eng-Ang Ling7Ying Ding8Yuan-Shan Zeng9Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou 510080, ChinaKey Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, ChinaKey Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou 510080, ChinaKey Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Acupuncture, The 1st Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaSpinal Cord Society Research Center, Fort Collins, CO 80526, USADepartment of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 117597, SingaporeDepartment of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, ChinaKey Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou 510080, ChinaSpinal cord injury (SCI) often results in death of spinal neurons and atrophy of muscles which they govern. Thus, following SCI, reorganizing the lumbar spinal sensorimotor pathways is crucial to alleviate muscle atrophy. Tail nerve electrical stimulation (TANES) has been shown to activate the central pattern generator (CPG) and improve the locomotion recovery of spinal contused rats. Electroacupuncture (EA) is a traditional Chinese medical practice which has been proven to have a neural protective effect. Here, we examined the effects of TANES and EA on lumbar motor neurons and hindlimb muscle in spinal transected rats, respectively. From the third day postsurgery, rats in the TANES group were treated 5 times a week and those in the EA group were treated once every other day. Four weeks later, both TANES and EA showed a significant impact in promoting survival of lumbar motor neurons and expression of choline acetyltransferase (ChAT) and ameliorating atrophy of hindlimb muscle after SCI. Meanwhile, the expression of neurotrophin-3 (NT-3) in the same spinal cord segment was significantly increased. These findings suggest that TANES and EA can augment the expression of NT-3 in the lumbar spinal cord that appears to protect the motor neurons as well as alleviate muscle atrophy.http://dx.doi.org/10.1155/2017/7351238 |
| spellingShingle | Yu-Ting Zhang Hui Jin Jun-Hua Wang Lan-Yu Wen Yang Yang Jing-Wen Ruan Shu-Xin Zhang Eng-Ang Ling Ying Ding Yuan-Shan Zeng Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats Neural Plasticity |
| title | Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats |
| title_full | Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats |
| title_fullStr | Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats |
| title_full_unstemmed | Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats |
| title_short | Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats |
| title_sort | tail nerve electrical stimulation and electro acupuncture can protect spinal motor neurons and alleviate muscle atrophy after spinal cord transection in rats |
| url | http://dx.doi.org/10.1155/2017/7351238 |
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