Prediction of subsequent vertebral fracture after percutaneous vertebral augmentation using MRI-based vertebral bone quality and CT-based Hounsfield units: a retrospective cross-sectional study
Abstract Subsequent vertebral fracture (SVF) is a common and refractory complication after percutaneous vertebral augmentation (PVA) for osteoporotic vertebral compression fracture (OVCF). Computed tomography (CT)-based Hounsfeld units (HU) and magnetic resonance imaging (MRI)-based vertebral bone q...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86721-5 |
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| author | Youdi Xue Kun Shi Weixiang Dai Chao Ma Jie Li |
| author_facet | Youdi Xue Kun Shi Weixiang Dai Chao Ma Jie Li |
| author_sort | Youdi Xue |
| collection | DOAJ |
| description | Abstract Subsequent vertebral fracture (SVF) is a common and refractory complication after percutaneous vertebral augmentation (PVA) for osteoporotic vertebral compression fracture (OVCF). Computed tomography (CT)-based Hounsfeld units (HU) and magnetic resonance imaging (MRI)-based vertebral bone quality (VBQ) score can evaluate osteoporosis quantitatively, hyperlipidemia(HLP) might affect measurement result of VBQ score. The primary objective of this study is to compare the predictive capabilities of HU and VBQ for SVF, and to clarify the impact of hyperlipidemia on the predictive abilities. This study included consecutive 341 patients with OVCF who were treated with PVA from March 1, 2020, to December 31, 2022. A multivariate logistic regression analysis was used to determine the relationship between HU and VBQ and SVF. ROC curves were plotted to calculate area under curve (AUC), and hoc analysis and Youden index was used to determine cut-off values of HU and VBQ. Compared with the non-SVF group, VBQ (4.69 ± 0.35 vs. 4.14 ± 0.41, P < 0.001) was higher and HU (58.2 ± 13.81 vs. 81.2 ± 16.68, P < 0.001) was lower in the SVF group. On multivariate logistic regression analysis, higher VBQ (odds ratio (OR) = 23.47,P < 0.001) and lower HU (OR = 0.93,P < 0.001) are independent predictors for SVF. The AUC using VBQ for predicting SVF was 0.84, the cut-off was 4.28. The AUC using HU for predicting SVF was 0.85, the cut-off was 64.40. In the HLP group, the AUC of VBQ was comparable with that of HU for SVF prediction, however, the sensitivity was lower in the HLP group (0.50 vs. 0.83). Furthermore, the AUC value of VBQ with HLP was lower than that of VBQ without HLP (0.78 vs. 0.90, P = 0.017). These findings demonstrated that both VBQ and HU can accurately predict the occurrence of SVF after PVA. HLP might cause a false increase of VBQ value, using HU could better assess bone quality and predict SVF occurrence when HLP is present. |
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| id | doaj-art-ab1c1298b7d44b49b6e133c3e40e4c96 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-ab1c1298b7d44b49b6e133c3e40e4c962025-02-02T12:22:17ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-86721-5Prediction of subsequent vertebral fracture after percutaneous vertebral augmentation using MRI-based vertebral bone quality and CT-based Hounsfield units: a retrospective cross-sectional studyYoudi Xue0Kun Shi1Weixiang Dai2Chao Ma3Jie Li4Department of Orthopaedics, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical UniversityDepartment of Orthopaedics, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical UniversityDepartment of Orthopaedics, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical UniversityDepartment of Orthopaedics, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical UniversityDepartment of Orthopaedics, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical UniversityAbstract Subsequent vertebral fracture (SVF) is a common and refractory complication after percutaneous vertebral augmentation (PVA) for osteoporotic vertebral compression fracture (OVCF). Computed tomography (CT)-based Hounsfeld units (HU) and magnetic resonance imaging (MRI)-based vertebral bone quality (VBQ) score can evaluate osteoporosis quantitatively, hyperlipidemia(HLP) might affect measurement result of VBQ score. The primary objective of this study is to compare the predictive capabilities of HU and VBQ for SVF, and to clarify the impact of hyperlipidemia on the predictive abilities. This study included consecutive 341 patients with OVCF who were treated with PVA from March 1, 2020, to December 31, 2022. A multivariate logistic regression analysis was used to determine the relationship between HU and VBQ and SVF. ROC curves were plotted to calculate area under curve (AUC), and hoc analysis and Youden index was used to determine cut-off values of HU and VBQ. Compared with the non-SVF group, VBQ (4.69 ± 0.35 vs. 4.14 ± 0.41, P < 0.001) was higher and HU (58.2 ± 13.81 vs. 81.2 ± 16.68, P < 0.001) was lower in the SVF group. On multivariate logistic regression analysis, higher VBQ (odds ratio (OR) = 23.47,P < 0.001) and lower HU (OR = 0.93,P < 0.001) are independent predictors for SVF. The AUC using VBQ for predicting SVF was 0.84, the cut-off was 4.28. The AUC using HU for predicting SVF was 0.85, the cut-off was 64.40. In the HLP group, the AUC of VBQ was comparable with that of HU for SVF prediction, however, the sensitivity was lower in the HLP group (0.50 vs. 0.83). Furthermore, the AUC value of VBQ with HLP was lower than that of VBQ without HLP (0.78 vs. 0.90, P = 0.017). These findings demonstrated that both VBQ and HU can accurately predict the occurrence of SVF after PVA. HLP might cause a false increase of VBQ value, using HU could better assess bone quality and predict SVF occurrence when HLP is present.https://doi.org/10.1038/s41598-025-86721-5Oeteoporotic vertebral compressive fractureSubsequent vertebral fractureHounsfield unitVertebral bone qualityHyperlipidemia |
| spellingShingle | Youdi Xue Kun Shi Weixiang Dai Chao Ma Jie Li Prediction of subsequent vertebral fracture after percutaneous vertebral augmentation using MRI-based vertebral bone quality and CT-based Hounsfield units: a retrospective cross-sectional study Scientific Reports Oeteoporotic vertebral compressive fracture Subsequent vertebral fracture Hounsfield unit Vertebral bone quality Hyperlipidemia |
| title | Prediction of subsequent vertebral fracture after percutaneous vertebral augmentation using MRI-based vertebral bone quality and CT-based Hounsfield units: a retrospective cross-sectional study |
| title_full | Prediction of subsequent vertebral fracture after percutaneous vertebral augmentation using MRI-based vertebral bone quality and CT-based Hounsfield units: a retrospective cross-sectional study |
| title_fullStr | Prediction of subsequent vertebral fracture after percutaneous vertebral augmentation using MRI-based vertebral bone quality and CT-based Hounsfield units: a retrospective cross-sectional study |
| title_full_unstemmed | Prediction of subsequent vertebral fracture after percutaneous vertebral augmentation using MRI-based vertebral bone quality and CT-based Hounsfield units: a retrospective cross-sectional study |
| title_short | Prediction of subsequent vertebral fracture after percutaneous vertebral augmentation using MRI-based vertebral bone quality and CT-based Hounsfield units: a retrospective cross-sectional study |
| title_sort | prediction of subsequent vertebral fracture after percutaneous vertebral augmentation using mri based vertebral bone quality and ct based hounsfield units a retrospective cross sectional study |
| topic | Oeteoporotic vertebral compressive fracture Subsequent vertebral fracture Hounsfield unit Vertebral bone quality Hyperlipidemia |
| url | https://doi.org/10.1038/s41598-025-86721-5 |
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