Pyridazine Based Compounds with PARP-1 Inhibitory Activity
Pyridazine-containing compounds have been identified as potent PARP1 inhibitors. The PARP is a family of enzymes essential for many cellular processes such as DNA repair, genomic stability, and apoptosis, also known as poly(ADP-ribose) synthetases and poly(ADP-ribose) transferases.PARP1 (Poly (ADP-r...
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| Main Authors: | Norhan A. Abdelrahman, Mai Y. Jaballah, Ahmed A. Al-Karmalawy, Khaled A. M. Abouzid |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ain Shams University
2023-12-01
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| Series: | Archives of Pharmaceutical Sciences Ain Shams University |
| Subjects: | |
| Online Access: | https://aps.journals.ekb.eg/article_320648.html |
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