Age-, season- and gender-specific reference intervals of serum 25-hydroxyvitamin D3 for healthy children (0 ~ 18 years old) in Nanning area of China
Abstract Establishing specific reference intervals (RIs) of serum 25-hydroxyvitamin D3 [25(OH)D] for children is essential for improving the accuracy of diagnosis and prognosis monitoring of diseases such as rickets and growth retardation. The study including 6,627 healthy children was conducted to...
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Elsevier
2024-01-01
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| Series: | Journal of Physiological Sciences |
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| Online Access: | https://doi.org/10.1186/s12576-023-00895-z |
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| author | Dong-yi Zhou Shang-mou Wei Chun-ling Zhu Yu-hong Wei Xiao-mei Wang Li-ling Yi Si-tao Yang Qi-liu Peng |
| author_facet | Dong-yi Zhou Shang-mou Wei Chun-ling Zhu Yu-hong Wei Xiao-mei Wang Li-ling Yi Si-tao Yang Qi-liu Peng |
| author_sort | Dong-yi Zhou |
| collection | DOAJ |
| description | Abstract Establishing specific reference intervals (RIs) of serum 25-hydroxyvitamin D3 [25(OH)D] for children is essential for improving the accuracy of diagnosis and prognosis monitoring of diseases such as rickets and growth retardation. The study including 6,627 healthy children was conducted to establish specific RIs of 25(OH)D for children in Nanning area of China. The results showed that there were statistically significant differences among age, season, and gender of serum 25(OH)D levels, and the age-specific RIs of serum 25(OH)D were 20.3 ~ 53.6 ng/mL for 0 ~ ≤ 1 year and 18.9 ~ 49.6 ng/mL for 2 ~ ≤ 3 years. The age-, season-specific RIs of serum 25(OH)D for 4 ~ ≤ 6 years in spring–summer and autumn–winter were 15.8 ~ 42.6 ng/mL and 15.2 ~ 37.7 ng/mL, respectively. The age-, gender-specific RIs of serum 25(OH)D for 7 ~ ≤ 18 years for males and females were 12.1 ~ 36.1 ng/mL and 10.8 ~ 35.3 ng/mL, respectively. This study successfully established the RIs of serum 25(OH)D, which may help to improve disease diagnosis and monitoring for children in the Nanning area of China. |
| format | Article |
| id | doaj-art-ab1a7ecc78f74bffaeb5c7746320e883 |
| institution | Kabale University |
| issn | 1880-6562 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Physiological Sciences |
| spelling | doaj-art-ab1a7ecc78f74bffaeb5c7746320e8832025-08-20T03:39:37ZengElsevierJournal of Physiological Sciences1880-65622024-01-017411710.1186/s12576-023-00895-zAge-, season- and gender-specific reference intervals of serum 25-hydroxyvitamin D3 for healthy children (0 ~ 18 years old) in Nanning area of ChinaDong-yi Zhou0Shang-mou Wei1Chun-ling Zhu2Yu-hong Wei3Xiao-mei Wang4Li-ling Yi5Si-tao Yang6Qi-liu Peng7Department of Clinical Laboratory, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese MedicineDepartment of Clinical Laboratory, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese MedicineDepartment of Clinical Laboratory, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese MedicineDepartment of Clinical Laboratory, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese MedicineDepartment of Clinical Laboratory, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese MedicineDepartment of Clinical Laboratory, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese MedicineDepartment of Clinical Laboratory, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese MedicineDepartment of Clinical Laboratory, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese MedicineAbstract Establishing specific reference intervals (RIs) of serum 25-hydroxyvitamin D3 [25(OH)D] for children is essential for improving the accuracy of diagnosis and prognosis monitoring of diseases such as rickets and growth retardation. The study including 6,627 healthy children was conducted to establish specific RIs of 25(OH)D for children in Nanning area of China. The results showed that there were statistically significant differences among age, season, and gender of serum 25(OH)D levels, and the age-specific RIs of serum 25(OH)D were 20.3 ~ 53.6 ng/mL for 0 ~ ≤ 1 year and 18.9 ~ 49.6 ng/mL for 2 ~ ≤ 3 years. The age-, season-specific RIs of serum 25(OH)D for 4 ~ ≤ 6 years in spring–summer and autumn–winter were 15.8 ~ 42.6 ng/mL and 15.2 ~ 37.7 ng/mL, respectively. The age-, gender-specific RIs of serum 25(OH)D for 7 ~ ≤ 18 years for males and females were 12.1 ~ 36.1 ng/mL and 10.8 ~ 35.3 ng/mL, respectively. This study successfully established the RIs of serum 25(OH)D, which may help to improve disease diagnosis and monitoring for children in the Nanning area of China.https://doi.org/10.1186/s12576-023-00895-zReference intervals (RIs)25-hydroxyvitamin D3 [25(OH)DVitamin DChildren |
| spellingShingle | Dong-yi Zhou Shang-mou Wei Chun-ling Zhu Yu-hong Wei Xiao-mei Wang Li-ling Yi Si-tao Yang Qi-liu Peng Age-, season- and gender-specific reference intervals of serum 25-hydroxyvitamin D3 for healthy children (0 ~ 18 years old) in Nanning area of China Journal of Physiological Sciences Reference intervals (RIs) 25-hydroxyvitamin D3 [25(OH)D Vitamin D Children |
| title | Age-, season- and gender-specific reference intervals of serum 25-hydroxyvitamin D3 for healthy children (0 ~ 18 years old) in Nanning area of China |
| title_full | Age-, season- and gender-specific reference intervals of serum 25-hydroxyvitamin D3 for healthy children (0 ~ 18 years old) in Nanning area of China |
| title_fullStr | Age-, season- and gender-specific reference intervals of serum 25-hydroxyvitamin D3 for healthy children (0 ~ 18 years old) in Nanning area of China |
| title_full_unstemmed | Age-, season- and gender-specific reference intervals of serum 25-hydroxyvitamin D3 for healthy children (0 ~ 18 years old) in Nanning area of China |
| title_short | Age-, season- and gender-specific reference intervals of serum 25-hydroxyvitamin D3 for healthy children (0 ~ 18 years old) in Nanning area of China |
| title_sort | age season and gender specific reference intervals of serum 25 hydroxyvitamin d3 for healthy children 0 18 years old in nanning area of china |
| topic | Reference intervals (RIs) 25-hydroxyvitamin D3 [25(OH)D Vitamin D Children |
| url | https://doi.org/10.1186/s12576-023-00895-z |
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