Features of the Immune Response in COVID-19
BACKGROUND This review is devoted to the analysis of the features of the immune response in COVID-19. The review indicates the clinical manifestations of COVID-19, modern data on the immunopathogenesis of the disease and its complications are considered.Aim of STUDY To clarify some pathogenetic mech...
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| Format: | Article |
| Language: | Russian |
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Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
2023-04-01
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| Series: | Неотложная медицинская помощь |
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| Online Access: | https://www.jnmp.ru/jour/article/view/1578 |
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| author | A. A. Inyutkina V. P. Nikulina M. A. Godkov |
| author_facet | A. A. Inyutkina V. P. Nikulina M. A. Godkov |
| author_sort | A. A. Inyutkina |
| collection | DOAJ |
| description | BACKGROUND This review is devoted to the analysis of the features of the immune response in COVID-19. The review indicates the clinical manifestations of COVID-19, modern data on the immunopathogenesis of the disease and its complications are considered.Aim of STUDY To clarify some pathogenetic mechanisms of the immune response in COVID-19, which can help in creating an algorithm for examining patients for early prognosis and prevention of severe course and complications of the disease.MATERIAL AND METHODS To achieve this goal, the results of domestic and foreign scientific studies on the pathogenesis, diagnosis and treatment of COVID-19 were analyzed. The literature search was carried out in electronic search engines Scopus and PubMed. For the analysis, scientific articles published in the period from 2019 to 2021 were selected; 88% of analyzed works are not older than 5 years.CONCLUSION The late production of type I IFN, an increase in the level of pro-inflammatory monocytes, a decrease in the expression of HLA-DR on monocytes, violation of the presentation of the virus and the formation of specific lymphocytes, the death of T-lymphocytes and profound immunosuppression are of greatest importance for the development of a severe form of COVID-19. |
| format | Article |
| id | doaj-art-ab18e0eca7e240df91c5b66ba5d95023 |
| institution | DOAJ |
| issn | 2223-9022 2541-8017 |
| language | Russian |
| publishDate | 2023-04-01 |
| publisher | Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department |
| record_format | Article |
| series | Неотложная медицинская помощь |
| spelling | doaj-art-ab18e0eca7e240df91c5b66ba5d950232025-08-20T02:59:28ZrusSklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare DepartmentНеотложная медицинская помощь2223-90222541-80172023-04-0112112212910.23934/2223-9022-2023-12-1-122-129841Features of the Immune Response in COVID-19A. A. Inyutkina0V. P. Nikulina1M. A. Godkov2Laboratory of Clinical Immunology, N.V. Sklifosovsky Research Institute for Emergency Medicine; Russian Medical Academy of Continuous Professional EducationN.V. Sklifosovsky Research Institute for Emergency MedicineLaboratory of Clinical Immunology, N.V. Sklifosovsky Research Institute for Emergency Medicine; Russian Medical Academy of Continuous Professional EducationBACKGROUND This review is devoted to the analysis of the features of the immune response in COVID-19. The review indicates the clinical manifestations of COVID-19, modern data on the immunopathogenesis of the disease and its complications are considered.Aim of STUDY To clarify some pathogenetic mechanisms of the immune response in COVID-19, which can help in creating an algorithm for examining patients for early prognosis and prevention of severe course and complications of the disease.MATERIAL AND METHODS To achieve this goal, the results of domestic and foreign scientific studies on the pathogenesis, diagnosis and treatment of COVID-19 were analyzed. The literature search was carried out in electronic search engines Scopus and PubMed. For the analysis, scientific articles published in the period from 2019 to 2021 were selected; 88% of analyzed works are not older than 5 years.CONCLUSION The late production of type I IFN, an increase in the level of pro-inflammatory monocytes, a decrease in the expression of HLA-DR on monocytes, violation of the presentation of the virus and the formation of specific lymphocytes, the death of T-lymphocytes and profound immunosuppression are of greatest importance for the development of a severe form of COVID-19.https://www.jnmp.ru/jour/article/view/1578covid-19cytokine stormantigen-presenting cellsmonocyteshla-drt-lymphocytesilifn |
| spellingShingle | A. A. Inyutkina V. P. Nikulina M. A. Godkov Features of the Immune Response in COVID-19 Неотложная медицинская помощь covid-19 cytokine storm antigen-presenting cells monocytes hla-dr t-lymphocytes il ifn |
| title | Features of the Immune Response in COVID-19 |
| title_full | Features of the Immune Response in COVID-19 |
| title_fullStr | Features of the Immune Response in COVID-19 |
| title_full_unstemmed | Features of the Immune Response in COVID-19 |
| title_short | Features of the Immune Response in COVID-19 |
| title_sort | features of the immune response in covid 19 |
| topic | covid-19 cytokine storm antigen-presenting cells monocytes hla-dr t-lymphocytes il ifn |
| url | https://www.jnmp.ru/jour/article/view/1578 |
| work_keys_str_mv | AT aainyutkina featuresoftheimmuneresponseincovid19 AT vpnikulina featuresoftheimmuneresponseincovid19 AT magodkov featuresoftheimmuneresponseincovid19 |