Giant Congenital Melanocytic Nevi in Neonates: Report of Two Cases
Giant congenital melanocytic nevi are rare, with an estimated incidence of approximately 1 in 20,000 live births. They increase the lifetime risk for malignant melanoma and neurological deficits, including leptomeningeal melanocytosis and epilepsy. Recently, we encountered two patients in whom giant...
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| Format: | Article |
| Language: | English |
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Elsevier
2010-02-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957210600125 |
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| author | Jen-Chung Chien Dau-Ming Niu Mao-Shan Wang Ming-Tzen Liu Jiing-Feng Lirng Shu-Jen Chen Betau Hwang |
| author_facet | Jen-Chung Chien Dau-Ming Niu Mao-Shan Wang Ming-Tzen Liu Jiing-Feng Lirng Shu-Jen Chen Betau Hwang |
| author_sort | Jen-Chung Chien |
| collection | DOAJ |
| description | Giant congenital melanocytic nevi are rare, with an estimated incidence of approximately 1 in 20,000 live births. They increase the lifetime risk for malignant melanoma and neurological deficits, including leptomeningeal melanocytosis and epilepsy. Recently, we encountered two patients in whom giant congenital melanocytic nevi were noted at birth. Case 1 presented with the largest nevus spreading across the posterior scalp, neck, chest wall, shoulder and upper back. At the age of 2 months, magnetic resonance imaging (MRI) was performed and no leptomeningeal melanocytosis was found. Case 2 presented with a huge nevus covering most parts of the lower abdomen, lower back, buttocks and bilateral upper thighs. She also had normal MRI findings in the newborn period. At the age of 7 years, leptomeningeal thickening on the surface of the junction between the pons and midbrain was found on brain MRI although she was neurologically asymptomatic. Here, we describe these two cases with congenital melanocytic nevi and review the literature about its clinical manifestations, outcomes, risks for malignant melanoma and neurocutaneous melanosis, and possible surgical interventions. |
| format | Article |
| id | doaj-art-ab178a3a73be4bbbb33b66cfefc78911 |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2010-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-ab178a3a73be4bbbb33b66cfefc789112025-08-20T02:20:12ZengElsevierPediatrics and Neonatology1875-95722010-02-01511616410.1016/S1875-9572(10)60012-5Giant Congenital Melanocytic Nevi in Neonates: Report of Two CasesJen-Chung Chien0Dau-Ming Niu1Mao-Shan Wang2Ming-Tzen Liu3Jiing-Feng Lirng4Shu-Jen Chen5Betau Hwang6Department of Pediatrics, Lo-Tung Pohai Hospital, Ilan, TaiwanDepartment of Pediatrics, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Plastic Surgery, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Dermatology, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Radiology, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Pediatrics, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Pediatrics, Taipei Veterans General Hospital, Taipei, TaiwanGiant congenital melanocytic nevi are rare, with an estimated incidence of approximately 1 in 20,000 live births. They increase the lifetime risk for malignant melanoma and neurological deficits, including leptomeningeal melanocytosis and epilepsy. Recently, we encountered two patients in whom giant congenital melanocytic nevi were noted at birth. Case 1 presented with the largest nevus spreading across the posterior scalp, neck, chest wall, shoulder and upper back. At the age of 2 months, magnetic resonance imaging (MRI) was performed and no leptomeningeal melanocytosis was found. Case 2 presented with a huge nevus covering most parts of the lower abdomen, lower back, buttocks and bilateral upper thighs. She also had normal MRI findings in the newborn period. At the age of 7 years, leptomeningeal thickening on the surface of the junction between the pons and midbrain was found on brain MRI although she was neurologically asymptomatic. Here, we describe these two cases with congenital melanocytic nevi and review the literature about its clinical manifestations, outcomes, risks for malignant melanoma and neurocutaneous melanosis, and possible surgical interventions.http://www.sciencedirect.com/science/article/pii/S1875957210600125giant congenitalmelanocytic nevimalignant melanomaneurocutaneous melanosis |
| spellingShingle | Jen-Chung Chien Dau-Ming Niu Mao-Shan Wang Ming-Tzen Liu Jiing-Feng Lirng Shu-Jen Chen Betau Hwang Giant Congenital Melanocytic Nevi in Neonates: Report of Two Cases Pediatrics and Neonatology giant congenital melanocytic nevi malignant melanoma neurocutaneous melanosis |
| title | Giant Congenital Melanocytic Nevi in Neonates: Report of Two Cases |
| title_full | Giant Congenital Melanocytic Nevi in Neonates: Report of Two Cases |
| title_fullStr | Giant Congenital Melanocytic Nevi in Neonates: Report of Two Cases |
| title_full_unstemmed | Giant Congenital Melanocytic Nevi in Neonates: Report of Two Cases |
| title_short | Giant Congenital Melanocytic Nevi in Neonates: Report of Two Cases |
| title_sort | giant congenital melanocytic nevi in neonates report of two cases |
| topic | giant congenital melanocytic nevi malignant melanoma neurocutaneous melanosis |
| url | http://www.sciencedirect.com/science/article/pii/S1875957210600125 |
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