P-Rex2 suppresses glucose uptake into liver and skeletal muscle through different adaptor functions

P-Rex2 suppresses glucose uptake into liver and skeletal muscle through different adaptor functions

Abstract P-Rex2 is a Rac guanine-nucleotide factor (Rac-GEF) that controls glucose homeostasis. This role is thought to be mediated through its adaptor function inhibiting Pten rather than through its Rac-GEF activity, but this remains to be demonstrated. To examine this question, we have investigat...

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Bibliographic Details
Main Authors: Elpida Tsonou, Julia Y. Chu, Polly A. Machin, Anna G. Roberts, Anne Segonds-Pichon, David Baker, David C. Hornigold, Heidi C. E. Welch
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
P-Rex2
P-Rex1
Guanine-nucleotide exchange factor (GEF)
Glucose homeostasis
Liver
Skeletal muscle
Online Access:https://doi.org/10.1038/s41598-025-01720-w
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