BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei.

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei.

While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle. However, these parasites lack a mitochondrial isoform of pyruvate d...

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Main Authors: Rebecca D Oppenheim, Darren J Creek, James I Macrae, Katarzyna K Modrzynska, Paco Pino, Julien Limenitakis, Valerie Polonais, Frank Seeber, Michael P Barrett, Oliver Billker, Malcolm J McConville, Dominique Soldati-Favre
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004263
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