Impact of myokines on chronic liver diseases: exploring the effects of metabolic dysfunction-associated steatotic liver disease (MASLD) on skeletal muscle. A narrative review
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition characterized by altered liver function due to fatty accumulation, which can lead to liver inflammation and, in advanced stages, liver carcinoma. MASLD is closely linked to several metabolic alterations, such as obesity...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2025-07-01
|
| Series: | European Journal of Translational Myology |
| Subjects: | |
| Online Access: | https://www.pagepressjournals.org/bam/article/view/13365 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850061681723441152 |
|---|---|
| author | Francisco Aguirre Mayalen Valero-Breton Daniel Cabrera Luis Peñailillo María Carolina Otero Claudia Fredes Claudio Cabello-Verrugio |
| author_facet | Francisco Aguirre Mayalen Valero-Breton Daniel Cabrera Luis Peñailillo María Carolina Otero Claudia Fredes Claudio Cabello-Verrugio |
| author_sort | Francisco Aguirre |
| collection | DOAJ |
| description | Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition characterized by altered liver function due to fatty accumulation, which can lead to liver inflammation and, in advanced stages, liver carcinoma. MASLD is closely linked to several metabolic alterations, such as obesity and insulin resistance, which directly affect skeletal muscles and contribute to the development of sarcopenia. Sarcopenia is the loss of muscle mass and strength, leading to decreased physical performance in severe stages. Skeletal muscles secrete molecules known as myokines under various conditions, such as exercise or diseases like MASLD. These myokines modulate communication between the skeletal muscle and other tissues. These myokines regulate muscle mass and, in pathological conditions, contribute to the development of sarcopenia. Emerging evidence highlights the crucial role of myokines in regulating skeletal muscle metabolism and function in MASLD. Myokines influence muscle metabolism, inflammation, and insulin sensitivity, offering potential therapeutic targets for managing muscle atrophy and sarcopenia in the context of MASLD. Understanding the interaction between myokines and skeletal muscle may lead to novel interventions to mitigate MASLD progression and sarcopenia. This review examines the mechanisms by which myokines regulate skeletal muscle metabolism and function in the context of MASLD.
|
| format | Article |
| id | doaj-art-ab0b5f46922344d68fe052d6d467a15a |
| institution | DOAJ |
| issn | 2037-7452 2037-7460 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Translational Myology |
| spelling | doaj-art-ab0b5f46922344d68fe052d6d467a15a2025-08-20T02:50:08ZengPAGEPress PublicationsEuropean Journal of Translational Myology2037-74522037-74602025-07-0110.4081/ejtm.2025.13365Impact of myokines on chronic liver diseases: exploring the effects of metabolic dysfunction-associated steatotic liver disease (MASLD) on skeletal muscle. A narrative reviewFrancisco Aguirre0Mayalen Valero-Breton1Daniel Cabrera2Luis Peñailillo3María Carolina Otero4Claudia Fredes5Claudio Cabello-Verrugio6Center for Research on Pandemic Resilience, Faculty of Life Sciences and Institute of Public Health, Universidad Andres Bello, Santiago, Chile; Laboratory of Muscle Pathology, Fragility and Aging, Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello, Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, Faculty of Life Sciences, Universidad Andres Bello, SantiagoCenter for Research on Pandemic Resilience, Faculty of Life Sciences and Institute of Public Health, Universidad Andres Bello, Santiago, Chile; Laboratory of Muscle Pathology, Fragility and Aging, Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello, Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, Faculty of Life Sciences, Universidad Andres Bello, SantiagoCenter for Biomedical Research and Innovation (CiiB), Faculty of Medicine, Universidad de los Andes, Santiago, Chile; Facultad de Ciencias de la Salud, Escuela de Kinesiología, Universidad Bernardo O Higgins, SantiagoExercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andrés Bello, SantiagoEscuela de Química y Farmacia, Facultad de Medicina, Universidad Andres Bello, SantiagoExercise and Rehabilitation Sciences Institute, Postgraduate, Faculty of Rehabilitation Sciences, Universidad Andres Bello, SantiagoCenter for Research on Pandemic Resilience, Faculty of Life Sciences and Institute of Public Health, Universidad Andres Bello, Santiago, Chile; Laboratory of Muscle Pathology, Fragility and Aging, Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello, Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, Faculty of Life Sciences, Universidad Andres Bello, SantiagoMetabolic dysfunction-associated steatotic liver disease (MASLD) is a condition characterized by altered liver function due to fatty accumulation, which can lead to liver inflammation and, in advanced stages, liver carcinoma. MASLD is closely linked to several metabolic alterations, such as obesity and insulin resistance, which directly affect skeletal muscles and contribute to the development of sarcopenia. Sarcopenia is the loss of muscle mass and strength, leading to decreased physical performance in severe stages. Skeletal muscles secrete molecules known as myokines under various conditions, such as exercise or diseases like MASLD. These myokines modulate communication between the skeletal muscle and other tissues. These myokines regulate muscle mass and, in pathological conditions, contribute to the development of sarcopenia. Emerging evidence highlights the crucial role of myokines in regulating skeletal muscle metabolism and function in MASLD. Myokines influence muscle metabolism, inflammation, and insulin sensitivity, offering potential therapeutic targets for managing muscle atrophy and sarcopenia in the context of MASLD. Understanding the interaction between myokines and skeletal muscle may lead to novel interventions to mitigate MASLD progression and sarcopenia. This review examines the mechanisms by which myokines regulate skeletal muscle metabolism and function in the context of MASLD. https://www.pagepressjournals.org/bam/article/view/13365Metabolic dysfunction-associated steatotic liver diseasesarcopeniamyokines |
| spellingShingle | Francisco Aguirre Mayalen Valero-Breton Daniel Cabrera Luis Peñailillo María Carolina Otero Claudia Fredes Claudio Cabello-Verrugio Impact of myokines on chronic liver diseases: exploring the effects of metabolic dysfunction-associated steatotic liver disease (MASLD) on skeletal muscle. A narrative review European Journal of Translational Myology Metabolic dysfunction-associated steatotic liver disease sarcopenia myokines |
| title | Impact of myokines on chronic liver diseases: exploring the effects of metabolic dysfunction-associated steatotic liver disease (MASLD) on skeletal muscle. A narrative review |
| title_full | Impact of myokines on chronic liver diseases: exploring the effects of metabolic dysfunction-associated steatotic liver disease (MASLD) on skeletal muscle. A narrative review |
| title_fullStr | Impact of myokines on chronic liver diseases: exploring the effects of metabolic dysfunction-associated steatotic liver disease (MASLD) on skeletal muscle. A narrative review |
| title_full_unstemmed | Impact of myokines on chronic liver diseases: exploring the effects of metabolic dysfunction-associated steatotic liver disease (MASLD) on skeletal muscle. A narrative review |
| title_short | Impact of myokines on chronic liver diseases: exploring the effects of metabolic dysfunction-associated steatotic liver disease (MASLD) on skeletal muscle. A narrative review |
| title_sort | impact of myokines on chronic liver diseases exploring the effects of metabolic dysfunction associated steatotic liver disease masld on skeletal muscle a narrative review |
| topic | Metabolic dysfunction-associated steatotic liver disease sarcopenia myokines |
| url | https://www.pagepressjournals.org/bam/article/view/13365 |
| work_keys_str_mv | AT franciscoaguirre impactofmyokinesonchronicliverdiseasesexploringtheeffectsofmetabolicdysfunctionassociatedsteatoticliverdiseasemasldonskeletalmuscleanarrativereview AT mayalenvalerobreton impactofmyokinesonchronicliverdiseasesexploringtheeffectsofmetabolicdysfunctionassociatedsteatoticliverdiseasemasldonskeletalmuscleanarrativereview AT danielcabrera impactofmyokinesonchronicliverdiseasesexploringtheeffectsofmetabolicdysfunctionassociatedsteatoticliverdiseasemasldonskeletalmuscleanarrativereview AT luispenailillo impactofmyokinesonchronicliverdiseasesexploringtheeffectsofmetabolicdysfunctionassociatedsteatoticliverdiseasemasldonskeletalmuscleanarrativereview AT mariacarolinaotero impactofmyokinesonchronicliverdiseasesexploringtheeffectsofmetabolicdysfunctionassociatedsteatoticliverdiseasemasldonskeletalmuscleanarrativereview AT claudiafredes impactofmyokinesonchronicliverdiseasesexploringtheeffectsofmetabolicdysfunctionassociatedsteatoticliverdiseasemasldonskeletalmuscleanarrativereview AT claudiocabelloverrugio impactofmyokinesonchronicliverdiseasesexploringtheeffectsofmetabolicdysfunctionassociatedsteatoticliverdiseasemasldonskeletalmuscleanarrativereview |