Is hypertension negatively associated with memory performance in women during climacteric? A systematic review
Abstract Background The negative association between hypertension and memory performance has been a subject of broad debate in recent decades. Considering the neuroendocrine changes that occur during climacteric, this systematic review aimed to investigate whether hypertension is negatively associat...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
|
| Series: | BMC Women's Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12905-025-03764-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849332395367464960 |
|---|---|
| author | Arthur Polveiro da Silva Laura Scatena Fávero Adriano Bruno Corrêa Mateus do Carmo Bardella Luís Felipe Pengo Almeida Leite Leonardo Santos Lopes da Silva Márcio Fernando Tasinafo Júnior Leonardo da Silva Gonçalves Camila de Moraes |
| author_facet | Arthur Polveiro da Silva Laura Scatena Fávero Adriano Bruno Corrêa Mateus do Carmo Bardella Luís Felipe Pengo Almeida Leite Leonardo Santos Lopes da Silva Márcio Fernando Tasinafo Júnior Leonardo da Silva Gonçalves Camila de Moraes |
| author_sort | Arthur Polveiro da Silva |
| collection | DOAJ |
| description | Abstract Background The negative association between hypertension and memory performance has been a subject of broad debate in recent decades. Considering the neuroendocrine changes that occur during climacteric, this systematic review aimed to investigate whether hypertension is negatively associated with memory performance in women during climacteric. Methods A comprehensive search was conducted in the MEDLINE, EMBASE, Web of Science, Scopus, and BVS electronic databases according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Studies involving hypertensive, middle-aged women in the climacteric phase were included. The risk of bias and methodological quality was assessed using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies (NHLBI, NIH). Results Out of 16 studies selected for the full-text reading phase, 5 were included in the systematic review. The included studies were predominantly longitudinal. Heterogeneity was observed in the sample size, and the tools for assessing memory, reproductive stage, and hypertension diagnosis. Two longitudinal studies reported a negative association between hypertension and memory performance, while one found no significant association. The cross-sectional studies reported that hypertensive participants demonstrated poorer memory performance compared to normotensive participants. Conclusions Based on the included studies, the results suggests that hypertension is negatively associated with memory performance in climacteric women. However, due to the small number of studies and the fact that most were conducted in developed countries, these results should be interpreted with caution (PROSPERO registration number: CRD42023391668). |
| format | Article |
| id | doaj-art-ab0886c2df1146c0a73fb60dcf8dbab5 |
| institution | Kabale University |
| issn | 1472-6874 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj-art-ab0886c2df1146c0a73fb60dcf8dbab52025-08-20T03:46:12ZengBMCBMC Women's Health1472-68742025-08-012511910.1186/s12905-025-03764-6Is hypertension negatively associated with memory performance in women during climacteric? A systematic reviewArthur Polveiro da Silva0Laura Scatena Fávero1Adriano Bruno Corrêa2Mateus do Carmo Bardella3Luís Felipe Pengo Almeida Leite4Leonardo Santos Lopes da Silva5Márcio Fernando Tasinafo Júnior6Leonardo da Silva Gonçalves7Camila de Moraes8School of Physical Education and Sports of Ribeirao Preto, University of São PauloSchool of Physical Education and Sports of Ribeirao Preto, University of São PauloSchool of Physical Education and Sports of Ribeirao Preto, University of São PauloSchool of Physical Education and Sports of Ribeirao Preto, University of São PauloSchool of Physical Education and Sports of Ribeirao Preto, University of São PauloSchool of Physical Education and Sports of Ribeirao Preto, University of São PauloSchool of Physical Education and Sports of Ribeirao Preto, University of São PauloSchool of Physical Education and Sports of Ribeirao Preto, University of São PauloSchool of Physical Education and Sports of Ribeirao Preto, University of São PauloAbstract Background The negative association between hypertension and memory performance has been a subject of broad debate in recent decades. Considering the neuroendocrine changes that occur during climacteric, this systematic review aimed to investigate whether hypertension is negatively associated with memory performance in women during climacteric. Methods A comprehensive search was conducted in the MEDLINE, EMBASE, Web of Science, Scopus, and BVS electronic databases according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Studies involving hypertensive, middle-aged women in the climacteric phase were included. The risk of bias and methodological quality was assessed using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies (NHLBI, NIH). Results Out of 16 studies selected for the full-text reading phase, 5 were included in the systematic review. The included studies were predominantly longitudinal. Heterogeneity was observed in the sample size, and the tools for assessing memory, reproductive stage, and hypertension diagnosis. Two longitudinal studies reported a negative association between hypertension and memory performance, while one found no significant association. The cross-sectional studies reported that hypertensive participants demonstrated poorer memory performance compared to normotensive participants. Conclusions Based on the included studies, the results suggests that hypertension is negatively associated with memory performance in climacteric women. However, due to the small number of studies and the fact that most were conducted in developed countries, these results should be interpreted with caution (PROSPERO registration number: CRD42023391668).https://doi.org/10.1186/s12905-025-03764-6Blood pressureCognitive functionMenopauseClimacteric |
| spellingShingle | Arthur Polveiro da Silva Laura Scatena Fávero Adriano Bruno Corrêa Mateus do Carmo Bardella Luís Felipe Pengo Almeida Leite Leonardo Santos Lopes da Silva Márcio Fernando Tasinafo Júnior Leonardo da Silva Gonçalves Camila de Moraes Is hypertension negatively associated with memory performance in women during climacteric? A systematic review BMC Women's Health Blood pressure Cognitive function Menopause Climacteric |
| title | Is hypertension negatively associated with memory performance in women during climacteric? A systematic review |
| title_full | Is hypertension negatively associated with memory performance in women during climacteric? A systematic review |
| title_fullStr | Is hypertension negatively associated with memory performance in women during climacteric? A systematic review |
| title_full_unstemmed | Is hypertension negatively associated with memory performance in women during climacteric? A systematic review |
| title_short | Is hypertension negatively associated with memory performance in women during climacteric? A systematic review |
| title_sort | is hypertension negatively associated with memory performance in women during climacteric a systematic review |
| topic | Blood pressure Cognitive function Menopause Climacteric |
| url | https://doi.org/10.1186/s12905-025-03764-6 |
| work_keys_str_mv | AT arthurpolveirodasilva ishypertensionnegativelyassociatedwithmemoryperformanceinwomenduringclimactericasystematicreview AT laurascatenafavero ishypertensionnegativelyassociatedwithmemoryperformanceinwomenduringclimactericasystematicreview AT adrianobrunocorrea ishypertensionnegativelyassociatedwithmemoryperformanceinwomenduringclimactericasystematicreview AT mateusdocarmobardella ishypertensionnegativelyassociatedwithmemoryperformanceinwomenduringclimactericasystematicreview AT luisfelipepengoalmeidaleite ishypertensionnegativelyassociatedwithmemoryperformanceinwomenduringclimactericasystematicreview AT leonardosantoslopesdasilva ishypertensionnegativelyassociatedwithmemoryperformanceinwomenduringclimactericasystematicreview AT marciofernandotasinafojunior ishypertensionnegativelyassociatedwithmemoryperformanceinwomenduringclimactericasystematicreview AT leonardodasilvagoncalves ishypertensionnegativelyassociatedwithmemoryperformanceinwomenduringclimactericasystematicreview AT camilademoraes ishypertensionnegativelyassociatedwithmemoryperformanceinwomenduringclimactericasystematicreview |