Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi009-A) from a patient with amyotrophic lateral sclerosis due to SOD1 mutation
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by progressive degeneration of nerve cells in the spinal cord and brain. We generated and characterized a human induced pluripotent stem cell (iPSC) line from skin fibroblasts of a patient with ALS due to SOD1 Mutatio...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506125000546 |
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| author | Bo Li Haoran Mu Didi Shan Yitong Yang Yingxin Wang Jianing Li Hongxu Wang Xiaohan Sun Xinbo Ji Zexin Zhan Yichang Jiao Yao Tang Bo Kong Bo Gao Yu Wang Ping Sun Fuchen Liu |
| author_facet | Bo Li Haoran Mu Didi Shan Yitong Yang Yingxin Wang Jianing Li Hongxu Wang Xiaohan Sun Xinbo Ji Zexin Zhan Yichang Jiao Yao Tang Bo Kong Bo Gao Yu Wang Ping Sun Fuchen Liu |
| author_sort | Bo Li |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by progressive degeneration of nerve cells in the spinal cord and brain. We generated and characterized a human induced pluripotent stem cell (iPSC) line from skin fibroblasts of a patient with ALS due to SOD1 Mutation. The pluripotency of these iPSCs was verified by the expression of several pluripotency markers at both RNA and protein levels, as well as their capability to differentiate into all three germ layers. |
| format | Article |
| id | doaj-art-ab06cf424a364d2d801b15f378ddd1cb |
| institution | OA Journals |
| issn | 1873-5061 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj-art-ab06cf424a364d2d801b15f378ddd1cb2025-08-20T02:24:33ZengElsevierStem Cell Research1873-50612025-06-018510370410.1016/j.scr.2025.103704Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi009-A) from a patient with amyotrophic lateral sclerosis due to SOD1 mutationBo Li0Haoran Mu1Didi Shan2Yitong Yang3Yingxin Wang4Jianing Li5Hongxu Wang6Xiaohan Sun7Xinbo Ji8Zexin Zhan9Yichang Jiao10Yao Tang11Bo Kong12Bo Gao13Yu Wang14Ping Sun15Fuchen Liu16Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaSchool of Nursing, Jining Medical University, Jining, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaDepartment of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaPrenatal Diagnostic Center of Obstetrics and Department of Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaPrenatal Diagnostic Center of Obstetrics and Department of Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China; Corresponding author.Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by progressive degeneration of nerve cells in the spinal cord and brain. We generated and characterized a human induced pluripotent stem cell (iPSC) line from skin fibroblasts of a patient with ALS due to SOD1 Mutation. The pluripotency of these iPSCs was verified by the expression of several pluripotency markers at both RNA and protein levels, as well as their capability to differentiate into all three germ layers.http://www.sciencedirect.com/science/article/pii/S1873506125000546 |
| spellingShingle | Bo Li Haoran Mu Didi Shan Yitong Yang Yingxin Wang Jianing Li Hongxu Wang Xiaohan Sun Xinbo Ji Zexin Zhan Yichang Jiao Yao Tang Bo Kong Bo Gao Yu Wang Ping Sun Fuchen Liu Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi009-A) from a patient with amyotrophic lateral sclerosis due to SOD1 mutation Stem Cell Research |
| title | Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi009-A) from a patient with amyotrophic lateral sclerosis due to SOD1 mutation |
| title_full | Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi009-A) from a patient with amyotrophic lateral sclerosis due to SOD1 mutation |
| title_fullStr | Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi009-A) from a patient with amyotrophic lateral sclerosis due to SOD1 mutation |
| title_full_unstemmed | Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi009-A) from a patient with amyotrophic lateral sclerosis due to SOD1 mutation |
| title_short | Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi009-A) from a patient with amyotrophic lateral sclerosis due to SOD1 mutation |
| title_sort | generation of an induced pluripotent stem cell ipsc line inndsui009 a from a patient with amyotrophic lateral sclerosis due to sod1 mutation |
| url | http://www.sciencedirect.com/science/article/pii/S1873506125000546 |
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