BONE MARROW INVOLVEMENT IN A PATIENT WITH ALPHA HEAVYCHAIN DISEASE:RESPONSE TO TETRACYCLINE TREATMENT
A 28-year-old man admitted with abdominal pain, weight loss and diarrhea. Barium x-ray studies showed segmentation, dilatation of bowel loops, mucosal folds thickening and delayed intestinal transit. Biopsy specimens histologically revelaed villous atrophy and plasmacytic infiltration limited to muc...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1829 |
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| author | Gokhan Sargin |
| author_facet | Gokhan Sargin |
| author_sort | Gokhan Sargin |
| collection | DOAJ |
| description | A 28-year-old man admitted with abdominal pain, weight loss and diarrhea. Barium x-ray studies showed segmentation, dilatation of bowel loops, mucosal folds thickening and delayed intestinal transit. Biopsy specimens histologically revelaed villous atrophy and plasmacytic infiltration limited to mucosa and submucosa. Computed tomography showed multiple lymphadenopathy in the abdomen. Serum protein electropheresis and immunoelectropheresis indicated elevated IgA concentration. Bone marrow aspiration and biopsy revealed presence of lymphoplasmacytic infiltration. Immunohistochemical analysis of the intestine, lymph node showed positivity for CD45, CD-79, CD-20. After tetracycline treatment the patient’s symptoms, abdominal lymphadenopathy and bone marrow infiltration disappeared and IgA concentration was normalized. |
| format | Article |
| id | doaj-art-aaf8d1db99264d829cd2685f8166ed6a |
| institution | DOAJ |
| issn | 2035-3006 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-aaf8d1db99264d829cd2685f8166ed6a2025-08-20T02:57:57ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-08-011BONE MARROW INVOLVEMENT IN A PATIENT WITH ALPHA HEAVYCHAIN DISEASE:RESPONSE TO TETRACYCLINE TREATMENTGokhan Sargin0Adnan Menderes University Medical Faculty, Division of HematologyA 28-year-old man admitted with abdominal pain, weight loss and diarrhea. Barium x-ray studies showed segmentation, dilatation of bowel loops, mucosal folds thickening and delayed intestinal transit. Biopsy specimens histologically revelaed villous atrophy and plasmacytic infiltration limited to mucosa and submucosa. Computed tomography showed multiple lymphadenopathy in the abdomen. Serum protein electropheresis and immunoelectropheresis indicated elevated IgA concentration. Bone marrow aspiration and biopsy revealed presence of lymphoplasmacytic infiltration. Immunohistochemical analysis of the intestine, lymph node showed positivity for CD45, CD-79, CD-20. After tetracycline treatment the patient’s symptoms, abdominal lymphadenopathy and bone marrow infiltration disappeared and IgA concentration was normalized.https://mjhid.org/index.php/mjhid/article/view/1829alpha heavy chainimmunoproliferative small intestinal diseaseMediterranean lymphomatetracycline |
| spellingShingle | Gokhan Sargin BONE MARROW INVOLVEMENT IN A PATIENT WITH ALPHA HEAVYCHAIN DISEASE:RESPONSE TO TETRACYCLINE TREATMENT Mediterranean Journal of Hematology and Infectious Diseases alpha heavy chain immunoproliferative small intestinal disease Mediterranean lymphoma tetracycline |
| title | BONE MARROW INVOLVEMENT IN A PATIENT WITH ALPHA HEAVYCHAIN DISEASE:RESPONSE TO TETRACYCLINE TREATMENT |
| title_full | BONE MARROW INVOLVEMENT IN A PATIENT WITH ALPHA HEAVYCHAIN DISEASE:RESPONSE TO TETRACYCLINE TREATMENT |
| title_fullStr | BONE MARROW INVOLVEMENT IN A PATIENT WITH ALPHA HEAVYCHAIN DISEASE:RESPONSE TO TETRACYCLINE TREATMENT |
| title_full_unstemmed | BONE MARROW INVOLVEMENT IN A PATIENT WITH ALPHA HEAVYCHAIN DISEASE:RESPONSE TO TETRACYCLINE TREATMENT |
| title_short | BONE MARROW INVOLVEMENT IN A PATIENT WITH ALPHA HEAVYCHAIN DISEASE:RESPONSE TO TETRACYCLINE TREATMENT |
| title_sort | bone marrow involvement in a patient with alpha heavychain disease response to tetracycline treatment |
| topic | alpha heavy chain immunoproliferative small intestinal disease Mediterranean lymphoma tetracycline |
| url | https://mjhid.org/index.php/mjhid/article/view/1829 |
| work_keys_str_mv | AT gokhansargin bonemarrowinvolvementinapatientwithalphaheavychaindiseaseresponsetotetracyclinetreatment |