Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus
Abstract Marburg virus (MARV) causes lethal hemorrhagic fever in humans, posing a threat to global health. We determined by cryogenic electron microscopy (cryo-EM) the MARV helical ribonucleoprotein (RNP) complex structure in single-layered conformation, which differs from the previously reported st...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54431-7 |
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| author | Luca Zinzula Florian Beck Marianna Camasta Stefan Bohn Chuan Liu Dustin Morado Andreas Bracher Juergen M. Plitzko Wolfgang Baumeister |
| author_facet | Luca Zinzula Florian Beck Marianna Camasta Stefan Bohn Chuan Liu Dustin Morado Andreas Bracher Juergen M. Plitzko Wolfgang Baumeister |
| author_sort | Luca Zinzula |
| collection | DOAJ |
| description | Abstract Marburg virus (MARV) causes lethal hemorrhagic fever in humans, posing a threat to global health. We determined by cryogenic electron microscopy (cryo-EM) the MARV helical ribonucleoprotein (RNP) complex structure in single-layered conformation, which differs from the previously reported structure of a double-layered helix. Our findings illuminate novel RNP interactions and expand knowledge on MARV genome packaging and nucleocapsid assembly, both processes representing attractive targets for the development of antiviral therapeutics against MARV disease. |
| format | Article |
| id | doaj-art-aaf69b8673694beca2c19722530bb25e |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-aaf69b8673694beca2c19722530bb25e2025-08-20T02:08:26ZengNature PortfolioNature Communications2041-17232024-11-0115111110.1038/s41467-024-54431-7Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virusLuca Zinzula0Florian Beck1Marianna Camasta2Stefan Bohn3Chuan Liu4Dustin Morado5Andreas Bracher6Juergen M. Plitzko7Wolfgang Baumeister8Max Planck Institute of Biochemistry, Research Group Molecular Structural BiologyMax Planck Institute of Biochemistry, Research Group Molecular Structural BiologyMax Planck Institute of Biochemistry, Research Group Molecular Structural BiologyMax Planck Institute of Biochemistry, Research Group Molecular Structural BiologyMax Planck Institute of Biochemistry, Research Group Molecular Structural BiologyMax Planck Institute of Biochemistry, Department of Cell and Virus StructureMax Planck Institute of Biochemistry, Department of Cellular BiochemistryMax Planck Institute of Biochemistry, Research Group Molecular Structural BiologyMax Planck Institute of Biochemistry, Research Group Molecular Structural BiologyAbstract Marburg virus (MARV) causes lethal hemorrhagic fever in humans, posing a threat to global health. We determined by cryogenic electron microscopy (cryo-EM) the MARV helical ribonucleoprotein (RNP) complex structure in single-layered conformation, which differs from the previously reported structure of a double-layered helix. Our findings illuminate novel RNP interactions and expand knowledge on MARV genome packaging and nucleocapsid assembly, both processes representing attractive targets for the development of antiviral therapeutics against MARV disease.https://doi.org/10.1038/s41467-024-54431-7 |
| spellingShingle | Luca Zinzula Florian Beck Marianna Camasta Stefan Bohn Chuan Liu Dustin Morado Andreas Bracher Juergen M. Plitzko Wolfgang Baumeister Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus Nature Communications |
| title | Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus |
| title_full | Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus |
| title_fullStr | Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus |
| title_full_unstemmed | Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus |
| title_short | Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus |
| title_sort | cryo em structure of single layered nucleoprotein rna complex from marburg virus |
| url | https://doi.org/10.1038/s41467-024-54431-7 |
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