Salivary IL-17A, IL-17F, and TNF-α Are Associated with Disease Advancement in Patients with Oral and Oropharyngeal Cancer
Delayed diagnosis of oral cavity and oropharyngeal cancer is associated with a poor prognosis. Despite progress in systemic therapy and radiotherapy, there has only been a slight improvement in the five-year survival rate. A non-invasive diagnostic method that consists of an assessment of specific p...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/3928504 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546965603221504 |
|---|---|
| author | Kinga Zielińska Bożenna Karczmarek-Borowska Konrad Kwaśniak Justyna Czarnik-Kwaśniak Aleksandra Ludwin Bogumił Lewandowski Jacek Tabarkiewicz |
| author_facet | Kinga Zielińska Bożenna Karczmarek-Borowska Konrad Kwaśniak Justyna Czarnik-Kwaśniak Aleksandra Ludwin Bogumił Lewandowski Jacek Tabarkiewicz |
| author_sort | Kinga Zielińska |
| collection | DOAJ |
| description | Delayed diagnosis of oral cavity and oropharyngeal cancer is associated with a poor prognosis. Despite progress in systemic therapy and radiotherapy, there has only been a slight improvement in the five-year survival rate. A non-invasive diagnostic method that consists of an assessment of specific proteins in saliva samples may significantly facilitate assessment of treatment results in patients diagnosed with oral and oropharyngeal cancer. The aim of this study was to assess the levels of IL-17 and TNF-α in the saliva of patients with oral and oropharyngeal cancer. The study was conducted prior to treatment in patients hospitalized in the Frederic Chopin Provincial Specialist Hospital No. 1 in Rzeszów, Poland. Saliva samples were collected from subjects on an empty stomach. Cytokine concentrations in the saliva were measured with ELISA and Luminex Multiplex Assays. The higher salivary concentrations of IL-17A, IL-17F, and TNF-α were significantly associated with disease advancement. Lower levels of IL-17A were associated with colonization of the oral cavity with aerobic bacteria. On the other hand, higher concentration of TNF-α was observed in patients with positive aerobic culture of oral swabs. Our results suggest that IL-17A, IL-17F, and TNF-α measured in the saliva may be a potential biomarker for cancer of the oral cavity and oropharynx. |
| format | Article |
| id | doaj-art-aaf0f2399fba4f44bde4fad07e39c0b3 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-aaf0f2399fba4f44bde4fad07e39c0b32025-02-03T06:46:35ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/39285043928504Salivary IL-17A, IL-17F, and TNF-α Are Associated with Disease Advancement in Patients with Oral and Oropharyngeal CancerKinga Zielińska0Bożenna Karczmarek-Borowska1Konrad Kwaśniak2Justyna Czarnik-Kwaśniak3Aleksandra Ludwin4Bogumił Lewandowski5Jacek Tabarkiewicz6Mrukmed Medical Centre, Rzeszów 35-922, PolandDepartment of Clinical Oncology, Subcarpatian Oncology Centre of The Specialist Hospital in Rzeszow No. 1, 35-055 Rzeszow, PolandLaboratory for Translational Research in Medicine, Centre for Innovative Research in Medical and Natural Sciences, College for Medical Sciences of University of Rzeszow, 35-310 Rzeszow, PolandLaboratory for Translational Research in Medicine, Centre for Innovative Research in Medical and Natural Sciences, College for Medical Sciences of University of Rzeszow, 35-310 Rzeszow, PolandLaboratory for Translational Research in Medicine, Centre for Innovative Research in Medical and Natural Sciences, College for Medical Sciences of University of Rzeszow, 35-310 Rzeszow, PolandDepartment of Oral and Maxillofacial Surgery, Institute of Medicine, College for Medical Sciences of University of Rzeszow, 35-959 Rzeszow, PolandLaboratory for Translational Research in Medicine, Centre for Innovative Research in Medical and Natural Sciences, College for Medical Sciences of University of Rzeszow, 35-310 Rzeszow, PolandDelayed diagnosis of oral cavity and oropharyngeal cancer is associated with a poor prognosis. Despite progress in systemic therapy and radiotherapy, there has only been a slight improvement in the five-year survival rate. A non-invasive diagnostic method that consists of an assessment of specific proteins in saliva samples may significantly facilitate assessment of treatment results in patients diagnosed with oral and oropharyngeal cancer. The aim of this study was to assess the levels of IL-17 and TNF-α in the saliva of patients with oral and oropharyngeal cancer. The study was conducted prior to treatment in patients hospitalized in the Frederic Chopin Provincial Specialist Hospital No. 1 in Rzeszów, Poland. Saliva samples were collected from subjects on an empty stomach. Cytokine concentrations in the saliva were measured with ELISA and Luminex Multiplex Assays. The higher salivary concentrations of IL-17A, IL-17F, and TNF-α were significantly associated with disease advancement. Lower levels of IL-17A were associated with colonization of the oral cavity with aerobic bacteria. On the other hand, higher concentration of TNF-α was observed in patients with positive aerobic culture of oral swabs. Our results suggest that IL-17A, IL-17F, and TNF-α measured in the saliva may be a potential biomarker for cancer of the oral cavity and oropharynx.http://dx.doi.org/10.1155/2020/3928504 |
| spellingShingle | Kinga Zielińska Bożenna Karczmarek-Borowska Konrad Kwaśniak Justyna Czarnik-Kwaśniak Aleksandra Ludwin Bogumił Lewandowski Jacek Tabarkiewicz Salivary IL-17A, IL-17F, and TNF-α Are Associated with Disease Advancement in Patients with Oral and Oropharyngeal Cancer Journal of Immunology Research |
| title | Salivary IL-17A, IL-17F, and TNF-α Are Associated with Disease Advancement in Patients with Oral and Oropharyngeal Cancer |
| title_full | Salivary IL-17A, IL-17F, and TNF-α Are Associated with Disease Advancement in Patients with Oral and Oropharyngeal Cancer |
| title_fullStr | Salivary IL-17A, IL-17F, and TNF-α Are Associated with Disease Advancement in Patients with Oral and Oropharyngeal Cancer |
| title_full_unstemmed | Salivary IL-17A, IL-17F, and TNF-α Are Associated with Disease Advancement in Patients with Oral and Oropharyngeal Cancer |
| title_short | Salivary IL-17A, IL-17F, and TNF-α Are Associated with Disease Advancement in Patients with Oral and Oropharyngeal Cancer |
| title_sort | salivary il 17a il 17f and tnf α are associated with disease advancement in patients with oral and oropharyngeal cancer |
| url | http://dx.doi.org/10.1155/2020/3928504 |
| work_keys_str_mv | AT kingazielinska salivaryil17ail17fandtnfaareassociatedwithdiseaseadvancementinpatientswithoralandoropharyngealcancer AT bozennakarczmarekborowska salivaryil17ail17fandtnfaareassociatedwithdiseaseadvancementinpatientswithoralandoropharyngealcancer AT konradkwasniak salivaryil17ail17fandtnfaareassociatedwithdiseaseadvancementinpatientswithoralandoropharyngealcancer AT justynaczarnikkwasniak salivaryil17ail17fandtnfaareassociatedwithdiseaseadvancementinpatientswithoralandoropharyngealcancer AT aleksandraludwin salivaryil17ail17fandtnfaareassociatedwithdiseaseadvancementinpatientswithoralandoropharyngealcancer AT bogumiłlewandowski salivaryil17ail17fandtnfaareassociatedwithdiseaseadvancementinpatientswithoralandoropharyngealcancer AT jacektabarkiewicz salivaryil17ail17fandtnfaareassociatedwithdiseaseadvancementinpatientswithoralandoropharyngealcancer |