Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania

Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania

Abstract The risk and prognosis of tuberculosis (TB) are influenced by a complex interplay between human and bacterial genetic factors. While previous genomic studies have largely examined human and bacterial genomes separately, we adopted an integrated approach to uncover host–pathogen interactions...

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Main Authors: Zhi Ming Xu, Michaela Zwyer, Hellen Hiza, Sarah Schmidiger, Mohamed Sasamalo, Miriam Reinhard, Anna Doetsch, Sonia Borrell, Olivier Naret, Sina Rüeger, Dylan Lawless, Simon Tang, Faima Isihaka, Hosiana Temba, Thomas Maroa, Rastard Naftari, Christian Beisel, Jerry Hella, Klaus Reither, Daniela Brites, Damien Portevin, Sebastien Gagneux, Jacques Fellay
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Medical Genomics
Subjects:
Tuberculosis
Human genetics of infection
Genome-wiide association study
Host-pathogen interactions
Online Access:https://doi.org/10.1186/s12920-025-02164-x
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