Association of metabolic syndrome components and their combinations with functional disability among older adults in a longevity-associated ethnic minority region of Southwest China
PurposeMetabolic syndrome (MetS) is associated with functional disability; however, the associations between combinations of MetS components and functional disabilities remain largely unexplored.MethodsThis cross-sectional study was conducted among adults aged ≥60 years in Donglan County. Basic acti...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1635390/full |
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| author | Haiyan Lu Wenjie Liang Hongyuan Huang Kaiyong Huang Lirong Zeng Li Yang |
| author_facet | Haiyan Lu Wenjie Liang Hongyuan Huang Kaiyong Huang Lirong Zeng Li Yang |
| author_sort | Haiyan Lu |
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| description | PurposeMetabolic syndrome (MetS) is associated with functional disability; however, the associations between combinations of MetS components and functional disabilities remain largely unexplored.MethodsThis cross-sectional study was conducted among adults aged ≥60 years in Donglan County. Basic activities of daily living (ADL) disability and instrumental activities of daily living (IADL) disability were identified using physical self-maintenance and IADL scales. Modified Poisson regression and restricted cubic splines were used to evaluate the associations of MetS, the number of MetS components, and combinations of MetS components with functional disability.ResultsA total of 4,450 participants were enrolled in this study. Abdominal obesity was associated with a 1.03-fold (95% CI: 1.01–1.05) higher ADL disability risk. Lower HDL cholesterol remained associated with a 4% reduced risk of IADL disability (PR = 0.96, 95% CI: 0.93–0.99). The combination of abdominal obesity, elevated blood pressure, and elevated fasting glucose was correlated with a 1.08-fold (95% CI: 1.01–1.14) higher risk of ADL disability and a 1.12-fold (95% CI: 1.05–1.19) higher risk of IADL disability.ConclusionLower HDL cholesterol levels may serve as a protective factor against IADL disability. The combination of abdominal obesity, elevated blood pressure, and elevated fasting glucose appears to represent the highest-risk combination for both ADL disability and IADL disability in the older adult population. |
| format | Article |
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| institution | OA Journals |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj-art-aae9f1f58fa249acb6f56a93cb8eade02025-08-20T02:35:56ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-07-011310.3389/fpubh.2025.16353901635390Association of metabolic syndrome components and their combinations with functional disability among older adults in a longevity-associated ethnic minority region of Southwest ChinaHaiyan Lu0Wenjie Liang1Hongyuan Huang2Kaiyong Huang3Lirong Zeng4Li Yang5Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, ChinaDepartment of Social Medicine, School of Public Health, Guangxi Medical University, Nanning, ChinaDepartment of Social Medicine, School of Public Health, Guangxi Medical University, Nanning, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, ChinaDepartment of Youth League Committee, School of Information and Management, Guangxi Medical University, Nanning, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, ChinaPurposeMetabolic syndrome (MetS) is associated with functional disability; however, the associations between combinations of MetS components and functional disabilities remain largely unexplored.MethodsThis cross-sectional study was conducted among adults aged ≥60 years in Donglan County. Basic activities of daily living (ADL) disability and instrumental activities of daily living (IADL) disability were identified using physical self-maintenance and IADL scales. Modified Poisson regression and restricted cubic splines were used to evaluate the associations of MetS, the number of MetS components, and combinations of MetS components with functional disability.ResultsA total of 4,450 participants were enrolled in this study. Abdominal obesity was associated with a 1.03-fold (95% CI: 1.01–1.05) higher ADL disability risk. Lower HDL cholesterol remained associated with a 4% reduced risk of IADL disability (PR = 0.96, 95% CI: 0.93–0.99). The combination of abdominal obesity, elevated blood pressure, and elevated fasting glucose was correlated with a 1.08-fold (95% CI: 1.01–1.14) higher risk of ADL disability and a 1.12-fold (95% CI: 1.05–1.19) higher risk of IADL disability.ConclusionLower HDL cholesterol levels may serve as a protective factor against IADL disability. The combination of abdominal obesity, elevated blood pressure, and elevated fasting glucose appears to represent the highest-risk combination for both ADL disability and IADL disability in the older adult population.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1635390/fullmetabolic syndromeADL disabilityIADL disabilitycomorbidityaging |
| spellingShingle | Haiyan Lu Wenjie Liang Hongyuan Huang Kaiyong Huang Lirong Zeng Li Yang Association of metabolic syndrome components and their combinations with functional disability among older adults in a longevity-associated ethnic minority region of Southwest China Frontiers in Public Health metabolic syndrome ADL disability IADL disability comorbidity aging |
| title | Association of metabolic syndrome components and their combinations with functional disability among older adults in a longevity-associated ethnic minority region of Southwest China |
| title_full | Association of metabolic syndrome components and their combinations with functional disability among older adults in a longevity-associated ethnic minority region of Southwest China |
| title_fullStr | Association of metabolic syndrome components and their combinations with functional disability among older adults in a longevity-associated ethnic minority region of Southwest China |
| title_full_unstemmed | Association of metabolic syndrome components and their combinations with functional disability among older adults in a longevity-associated ethnic minority region of Southwest China |
| title_short | Association of metabolic syndrome components and their combinations with functional disability among older adults in a longevity-associated ethnic minority region of Southwest China |
| title_sort | association of metabolic syndrome components and their combinations with functional disability among older adults in a longevity associated ethnic minority region of southwest china |
| topic | metabolic syndrome ADL disability IADL disability comorbidity aging |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1635390/full |
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