Secondary hemophagocytic lymphohistiocytosis in a child with Leptospira infection: A case report
Leptospirosis caused by spirochetes of the genus Leptospira in most patients result in very mild illness without jaundice. However, a small portion of patients develop various complications due to the involvement of multiple organ systems. Hemophagocytic lymphohistiocytosis is characterized by prol...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2018-12-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/930 |
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| author | Dragana Jevtic Dragomir Djokic Danka Redzic Dragana Aleksic Miro Parezanovic Srdjan Pasic |
| author_facet | Dragana Jevtic Dragomir Djokic Danka Redzic Dragana Aleksic Miro Parezanovic Srdjan Pasic |
| author_sort | Dragana Jevtic |
| collection | DOAJ |
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Leptospirosis caused by spirochetes of the genus Leptospira in most patients result in very mild illness without jaundice. However, a small portion of patients develop various complications due to the involvement of multiple organ systems. Hemophagocytic lymphohistiocytosis is characterized by prolonged fever, hepatosplenomegaly and cytopenias, hyperferritinemia and hypertriglyceridemias, hyperfibrinogenemia, and hemophagocytosis in bone marrow, lymph nodes, spleen, or liver. Hemophagocytic lymphohistiocytosis associated with leptospirosis is a very rare condition and it should be considered in patients with multiple organ dysfunctions, together with adequate laboratory findings. It can delay the correct diagnosis of leptospirosis and contribute to an adverse outcome. We present a 13-year-old girl with secondary hemophagocytic lymphohistiocytosis caused by leptospira infection and favorable outcome with appropriate antibiotics and corticosteroid therapy.
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| format | Article |
| id | doaj-art-aae8594cb26e4f3b9b935e9ee1548ebc |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-aae8594cb26e4f3b9b935e9ee1548ebc2025-08-20T03:01:14ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212018-12-0160610.24953/turkjped.2018.06.016Secondary hemophagocytic lymphohistiocytosis in a child with Leptospira infection: A case reportDragana Jevtic0Dragomir Djokic1Danka Redzic2Dragana Aleksic3Miro Parezanovic4Srdjan Pasic5Departments of Hemato-Oncology II, Mother and Child Health Care Institute of Serbia, Radoja Dakica St., Belgrade, Serbia.Departments of Hemato-Oncology II, Mother and Child Health Care Institute of Serbia, Radoja Dakica St., Belgrade, Serbia.Departments of Hemato-Oncology II, Mother and Child Health Care Institute of Serbia, Radoja Dakica St., Belgrade, Serbia.Departments of Hemato-Oncology II, Mother and Child Health Care Institute of Serbia, Radoja Dakica St., Belgrade, Serbia.Mother and Child Health Care Institute of Serbia, Radoja Dakica St., Belgrade, Serbia.Departments of Immunology, Mother and Child Health Care Institute of Serbia, Radoja Dakica St., Belgrade, Serbia. Leptospirosis caused by spirochetes of the genus Leptospira in most patients result in very mild illness without jaundice. However, a small portion of patients develop various complications due to the involvement of multiple organ systems. Hemophagocytic lymphohistiocytosis is characterized by prolonged fever, hepatosplenomegaly and cytopenias, hyperferritinemia and hypertriglyceridemias, hyperfibrinogenemia, and hemophagocytosis in bone marrow, lymph nodes, spleen, or liver. Hemophagocytic lymphohistiocytosis associated with leptospirosis is a very rare condition and it should be considered in patients with multiple organ dysfunctions, together with adequate laboratory findings. It can delay the correct diagnosis of leptospirosis and contribute to an adverse outcome. We present a 13-year-old girl with secondary hemophagocytic lymphohistiocytosis caused by leptospira infection and favorable outcome with appropriate antibiotics and corticosteroid therapy. https://turkjpediatr.org/article/view/930hemophagocytic lymphohistiocytosisleptospirosismultiorgan failure |
| spellingShingle | Dragana Jevtic Dragomir Djokic Danka Redzic Dragana Aleksic Miro Parezanovic Srdjan Pasic Secondary hemophagocytic lymphohistiocytosis in a child with Leptospira infection: A case report The Turkish Journal of Pediatrics hemophagocytic lymphohistiocytosis leptospirosis multiorgan failure |
| title | Secondary hemophagocytic lymphohistiocytosis in a child with Leptospira infection: A case report |
| title_full | Secondary hemophagocytic lymphohistiocytosis in a child with Leptospira infection: A case report |
| title_fullStr | Secondary hemophagocytic lymphohistiocytosis in a child with Leptospira infection: A case report |
| title_full_unstemmed | Secondary hemophagocytic lymphohistiocytosis in a child with Leptospira infection: A case report |
| title_short | Secondary hemophagocytic lymphohistiocytosis in a child with Leptospira infection: A case report |
| title_sort | secondary hemophagocytic lymphohistiocytosis in a child with leptospira infection a case report |
| topic | hemophagocytic lymphohistiocytosis leptospirosis multiorgan failure |
| url | https://turkjpediatr.org/article/view/930 |
| work_keys_str_mv | AT draganajevtic secondaryhemophagocyticlymphohistiocytosisinachildwithleptospirainfectionacasereport AT dragomirdjokic secondaryhemophagocyticlymphohistiocytosisinachildwithleptospirainfectionacasereport AT dankaredzic secondaryhemophagocyticlymphohistiocytosisinachildwithleptospirainfectionacasereport AT draganaaleksic secondaryhemophagocyticlymphohistiocytosisinachildwithleptospirainfectionacasereport AT miroparezanovic secondaryhemophagocyticlymphohistiocytosisinachildwithleptospirainfectionacasereport AT srdjanpasic secondaryhemophagocyticlymphohistiocytosisinachildwithleptospirainfectionacasereport |