CD47-SIRPα Axis as a Biomarker and Therapeutic Target in Cancer: Current Perspectives and Future Challenges in Nonsmall Cell Lung Cancer
CD47 is a cell surface protein in the immunoglobulin superfamily which is normally expressed at low levels in every healthy cell. It´s main physiologic function is to act as an inhibitor of phagocytosis; this occurs throughout interaction with SIRPa expressed on macrophages. Interaction between CD47...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/9435030 |
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| author | Rodrigo Catalán Mario Orozco-Morales Norma Y. Hernández-Pedro Alberto Guijosa Ana L. Colín-González Federico Ávila-Moreno Oscar Arrieta |
| author_facet | Rodrigo Catalán Mario Orozco-Morales Norma Y. Hernández-Pedro Alberto Guijosa Ana L. Colín-González Federico Ávila-Moreno Oscar Arrieta |
| author_sort | Rodrigo Catalán |
| collection | DOAJ |
| description | CD47 is a cell surface protein in the immunoglobulin superfamily which is normally expressed at low levels in every healthy cell. It´s main physiologic function is to act as an inhibitor of phagocytosis; this occurs throughout interaction with SIRPa expressed on macrophages. Interaction between CD47 and SIRPa leads to activation of tyrosine phosphatases that inhibit myosin accumulation at the submembrane assembly site of the phagocytic synapse, resulting in phagocytosis blockade. In this way CD47 acts as a “don´t eat me signal” for healthy self-cells; accordingly, loss of CD47 leads to phagocytosis of aged or damaged cells. Taking advantage of this anti-phagocytic signal provided by CD47, many types of tumors overexpress this protein, thereby avoiding phagocytosis by macrophages and aiding in the survival of cancer cells. The aim of this review is to describe the physiologic the pathophysiologic role of CD47; summarize the available high-quality information about this molecule as a potential biomarker and/or therapeutic target in cancer; finally, we present an in-depth analysis of the available information about CD47 in association with nonsmall cell lung cancer, EGFR mutations, and tumor microenvironment. |
| format | Article |
| id | doaj-art-aae5d036e1e54e1bb06d0cb47eecf8f5 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-aae5d036e1e54e1bb06d0cb47eecf8f52025-08-20T03:39:40ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/94350309435030CD47-SIRPα Axis as a Biomarker and Therapeutic Target in Cancer: Current Perspectives and Future Challenges in Nonsmall Cell Lung CancerRodrigo Catalán0Mario Orozco-Morales1Norma Y. Hernández-Pedro2Alberto Guijosa3Ana L. Colín-González4Federico Ávila-Moreno5Oscar Arrieta6Thoracic Oncology Unit, Instituto Nacional de Cancerología, Mexico City, MexicoLaboratory of Personalized Medicine, Instituto Nacional de Cancerología, Mexico City, MexicoLaboratory of Personalized Medicine, Instituto Nacional de Cancerología, Mexico City, MexicoLaboratory of Personalized Medicine, Instituto Nacional de Cancerología, Mexico City, MexicoLaboratory of Personalized Medicine, Instituto Nacional de Cancerología, Mexico City, MexicoLung Diseases and Cancer Epigenomics Laboratory, Biomedicine Research Unit (UBIMED), Facultad de Estudios Superiores (FES) Iztacala, Universidad Nacional Autónoma de Mexico (UNAM), Mexico State, MexicoThoracic Oncology Unit, Instituto Nacional de Cancerología, Mexico City, MexicoCD47 is a cell surface protein in the immunoglobulin superfamily which is normally expressed at low levels in every healthy cell. It´s main physiologic function is to act as an inhibitor of phagocytosis; this occurs throughout interaction with SIRPa expressed on macrophages. Interaction between CD47 and SIRPa leads to activation of tyrosine phosphatases that inhibit myosin accumulation at the submembrane assembly site of the phagocytic synapse, resulting in phagocytosis blockade. In this way CD47 acts as a “don´t eat me signal” for healthy self-cells; accordingly, loss of CD47 leads to phagocytosis of aged or damaged cells. Taking advantage of this anti-phagocytic signal provided by CD47, many types of tumors overexpress this protein, thereby avoiding phagocytosis by macrophages and aiding in the survival of cancer cells. The aim of this review is to describe the physiologic the pathophysiologic role of CD47; summarize the available high-quality information about this molecule as a potential biomarker and/or therapeutic target in cancer; finally, we present an in-depth analysis of the available information about CD47 in association with nonsmall cell lung cancer, EGFR mutations, and tumor microenvironment.http://dx.doi.org/10.1155/2020/9435030 |
| spellingShingle | Rodrigo Catalán Mario Orozco-Morales Norma Y. Hernández-Pedro Alberto Guijosa Ana L. Colín-González Federico Ávila-Moreno Oscar Arrieta CD47-SIRPα Axis as a Biomarker and Therapeutic Target in Cancer: Current Perspectives and Future Challenges in Nonsmall Cell Lung Cancer Journal of Immunology Research |
| title | CD47-SIRPα Axis as a Biomarker and Therapeutic Target in Cancer: Current Perspectives and Future Challenges in Nonsmall Cell Lung Cancer |
| title_full | CD47-SIRPα Axis as a Biomarker and Therapeutic Target in Cancer: Current Perspectives and Future Challenges in Nonsmall Cell Lung Cancer |
| title_fullStr | CD47-SIRPα Axis as a Biomarker and Therapeutic Target in Cancer: Current Perspectives and Future Challenges in Nonsmall Cell Lung Cancer |
| title_full_unstemmed | CD47-SIRPα Axis as a Biomarker and Therapeutic Target in Cancer: Current Perspectives and Future Challenges in Nonsmall Cell Lung Cancer |
| title_short | CD47-SIRPα Axis as a Biomarker and Therapeutic Target in Cancer: Current Perspectives and Future Challenges in Nonsmall Cell Lung Cancer |
| title_sort | cd47 sirpα axis as a biomarker and therapeutic target in cancer current perspectives and future challenges in nonsmall cell lung cancer |
| url | http://dx.doi.org/10.1155/2020/9435030 |
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