Recent progress in the identification and in vitro culture of skin organoids
An organoid is a cell-based structure that shows organ-specific properties and shares a similar spatial organization as the corresponding organ. Organoids possess powerful capability to reproduce the key functions of the associated organ structures, and their similarity to the organs makes them phys...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S235232042500001X |
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| author | Yanan Huang Qing Ye Jiyuan Wang Kaimin Zhu Haojie Yang Xiaoping Jiang Meihua Shen |
| author_facet | Yanan Huang Qing Ye Jiyuan Wang Kaimin Zhu Haojie Yang Xiaoping Jiang Meihua Shen |
| author_sort | Yanan Huang |
| collection | DOAJ |
| description | An organoid is a cell-based structure that shows organ-specific properties and shares a similar spatial organization as the corresponding organ. Organoids possess powerful capability to reproduce the key functions of the associated organ structures, and their similarity to the organs makes them physiologically relevant systems. The primary challenge associated with the development of skin organoids is the complexity of the human skin architecture, which encompasses the epidermis and the dermis as well as accessory structures, including hair follicles, sweat glands, and sebaceous glands, that perform various functions such as thermoregulation. The ultimate objectives of developing skin organoids are to regenerate the complete skin structure in vitro and reconstruct the skin in vivo. Consequently, safety, reliability, and the fidelity of the tissue interfaces are key considerations in this process. For this purpose, the present article reviews the most recent advances in this field, focusing on the cell sources, culture methods, culture conditions, and biomarkers for identifying the structure and function of skin organoids developed in vitro or in vivo. The subsequent sections summarize the recent applications of skin organoids in related disease diagnosis and treatments, and discuss the future prospects of these organoids in terms of clinical applications. This review of skin organoids can provide an important foundation for studies on human skin development, disease modeling, and reconstructive surgery, with broad utility for promising future opportunities in both biomedical research and clinical practice. |
| format | Article |
| id | doaj-art-aae334d3ef8449edafc4347ac4998074 |
| institution | OA Journals |
| issn | 2352-3204 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-aae334d3ef8449edafc4347ac49980742025-08-20T02:15:28ZengElsevierRegenerative Therapy2352-32042025-06-012934135110.1016/j.reth.2025.01.001Recent progress in the identification and in vitro culture of skin organoidsYanan Huang0Qing Ye1Jiyuan Wang2Kaimin Zhu3Haojie Yang4Xiaoping Jiang5Meihua Shen6Shanghai Corps Hospital of Chinese People's Armed Police, ChinaShanghai Corps Hospital of Chinese People's Armed Police, ChinaShanghai Changzheng Hospital, ChinaShanghai Corps Hospital of Chinese People's Armed Police, ChinaYueyang Hospital of Integrated Traditional Chinese and Western Medicine, ChinaShanghai Corps Hospital of Chinese People's Armed Police, China; Corresponding author.Shanghai Corps Hospital of Chinese People's Armed Police, China; Corresponding author.An organoid is a cell-based structure that shows organ-specific properties and shares a similar spatial organization as the corresponding organ. Organoids possess powerful capability to reproduce the key functions of the associated organ structures, and their similarity to the organs makes them physiologically relevant systems. The primary challenge associated with the development of skin organoids is the complexity of the human skin architecture, which encompasses the epidermis and the dermis as well as accessory structures, including hair follicles, sweat glands, and sebaceous glands, that perform various functions such as thermoregulation. The ultimate objectives of developing skin organoids are to regenerate the complete skin structure in vitro and reconstruct the skin in vivo. Consequently, safety, reliability, and the fidelity of the tissue interfaces are key considerations in this process. For this purpose, the present article reviews the most recent advances in this field, focusing on the cell sources, culture methods, culture conditions, and biomarkers for identifying the structure and function of skin organoids developed in vitro or in vivo. The subsequent sections summarize the recent applications of skin organoids in related disease diagnosis and treatments, and discuss the future prospects of these organoids in terms of clinical applications. This review of skin organoids can provide an important foundation for studies on human skin development, disease modeling, and reconstructive surgery, with broad utility for promising future opportunities in both biomedical research and clinical practice.http://www.sciencedirect.com/science/article/pii/S235232042500001XHair follicleRegenerationTissue engineeringIdentificationIn vitro culture |
| spellingShingle | Yanan Huang Qing Ye Jiyuan Wang Kaimin Zhu Haojie Yang Xiaoping Jiang Meihua Shen Recent progress in the identification and in vitro culture of skin organoids Regenerative Therapy Hair follicle Regeneration Tissue engineering Identification In vitro culture |
| title | Recent progress in the identification and in vitro culture of skin organoids |
| title_full | Recent progress in the identification and in vitro culture of skin organoids |
| title_fullStr | Recent progress in the identification and in vitro culture of skin organoids |
| title_full_unstemmed | Recent progress in the identification and in vitro culture of skin organoids |
| title_short | Recent progress in the identification and in vitro culture of skin organoids |
| title_sort | recent progress in the identification and in vitro culture of skin organoids |
| topic | Hair follicle Regeneration Tissue engineering Identification In vitro culture |
| url | http://www.sciencedirect.com/science/article/pii/S235232042500001X |
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