Deciphering the role of host-gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancer
Abstract Colorectal cancer is the most common type of cancer in the digestive system and poses a major threat to human health. The gut microbiota has been found to be a key factor influencing the development of colorectal cancer. Extracellular vesicles are important mediators of intercellular commun...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Molecular Medicine |
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| Online Access: | https://doi.org/10.1186/s10020-024-00976-8 |
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| author | Yun Song Min Shi Yugang Wang |
| author_facet | Yun Song Min Shi Yugang Wang |
| author_sort | Yun Song |
| collection | DOAJ |
| description | Abstract Colorectal cancer is the most common type of cancer in the digestive system and poses a major threat to human health. The gut microbiota has been found to be a key factor influencing the development of colorectal cancer. Extracellular vesicles are important mediators of intercellular communication. Not only do they regulate life activities within the same individual, but they have also been found in recent years to be important mediators of communication between different species, such as the gut microbiota and the host. Their preventive, diagnostic, and therapeutic value in colorectal cancer is being explored. The aim of this review is to provide insights into the complex interactions between host and gut microbiota, particularly those mediated through extracellular vesicles, and how these interactions affect colorectal cancer development. In addition, the potential of extracellular vesicles from various body fluids as biomarkers was evaluated. Finally, we discuss the potential, challenges, and future research directions of extracellular vesicles in their application to colorectal cancer. Overall, extracellular vesicles have great potential for application in medical processes related to colorectal cancer, but their isolation and characterization techniques, intercellular communication mechanisms, and the effectiveness of their clinical application require further research and exploration. |
| format | Article |
| id | doaj-art-aae20eb3bfd7416ca5f4bea47b2c6834 |
| institution | DOAJ |
| issn | 1528-3658 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj-art-aae20eb3bfd7416ca5f4bea47b2c68342025-08-20T02:50:07ZengBMCMolecular Medicine1528-36582024-11-0130111910.1186/s10020-024-00976-8Deciphering the role of host-gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancerYun Song0Min Shi1Yugang Wang2Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of MedicineAbstract Colorectal cancer is the most common type of cancer in the digestive system and poses a major threat to human health. The gut microbiota has been found to be a key factor influencing the development of colorectal cancer. Extracellular vesicles are important mediators of intercellular communication. Not only do they regulate life activities within the same individual, but they have also been found in recent years to be important mediators of communication between different species, such as the gut microbiota and the host. Their preventive, diagnostic, and therapeutic value in colorectal cancer is being explored. The aim of this review is to provide insights into the complex interactions between host and gut microbiota, particularly those mediated through extracellular vesicles, and how these interactions affect colorectal cancer development. In addition, the potential of extracellular vesicles from various body fluids as biomarkers was evaluated. Finally, we discuss the potential, challenges, and future research directions of extracellular vesicles in their application to colorectal cancer. Overall, extracellular vesicles have great potential for application in medical processes related to colorectal cancer, but their isolation and characterization techniques, intercellular communication mechanisms, and the effectiveness of their clinical application require further research and exploration.https://doi.org/10.1186/s10020-024-00976-8Extracellular vesiclesExosomesColorectal neoplasmsGastrointestinal microbiomeProbiotics |
| spellingShingle | Yun Song Min Shi Yugang Wang Deciphering the role of host-gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancer Molecular Medicine Extracellular vesicles Exosomes Colorectal neoplasms Gastrointestinal microbiome Probiotics |
| title | Deciphering the role of host-gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancer |
| title_full | Deciphering the role of host-gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancer |
| title_fullStr | Deciphering the role of host-gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancer |
| title_full_unstemmed | Deciphering the role of host-gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancer |
| title_short | Deciphering the role of host-gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancer |
| title_sort | deciphering the role of host gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancer |
| topic | Extracellular vesicles Exosomes Colorectal neoplasms Gastrointestinal microbiome Probiotics |
| url | https://doi.org/10.1186/s10020-024-00976-8 |
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