Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.

Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.

There are two major pathways leading to induction of NF-κB subunits. The classical (or canonical) pathway typically leads to the induction of RelA or c-Rel containing complexes, and involves the degradation of IκBα in a manner dependent on IκB kinase (IKK) β and the IKK regulatory subunit NEMO. The...

Full description

Saved in:
Bibliographic Details
Main Authors: Alessio Iannetti, Adeline C Ledoux, Susan J Tudhope, Hélène Sellier, Bo Zhao, Sophia Mowla, Adam Moore, Holger Hummerich, Benjamin E Gewurz, Simon J Cockell, Parmjit S Jat, Elaine Willmore, Neil D Perkins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-09-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1004642
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items