Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives
Proteostasis involves processes that are fundamental for neural viability. Thus, protein misfolding and the formation of toxic aggregates at neural level, secondary to dysregulation of the conservative mechanisms of proteostasis, are associated with several neuropsychiatric conditions. It has been o...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/6798712 |
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| author | Pablo Olivero Carlo Lozano Ramón Sotomayor-Zárate Nicolás Meza-Concha Marcelo Arancibia Claudio Córdova Wilfredo González-Arriagada Ricardo Ramírez-Barrantes Ivanny Marchant |
| author_facet | Pablo Olivero Carlo Lozano Ramón Sotomayor-Zárate Nicolás Meza-Concha Marcelo Arancibia Claudio Córdova Wilfredo González-Arriagada Ricardo Ramírez-Barrantes Ivanny Marchant |
| author_sort | Pablo Olivero |
| collection | DOAJ |
| description | Proteostasis involves processes that are fundamental for neural viability. Thus, protein misfolding and the formation of toxic aggregates at neural level, secondary to dysregulation of the conservative mechanisms of proteostasis, are associated with several neuropsychiatric conditions. It has been observed that impaired mitochondrial function due to a dysregulated proteostasis control system, that is, ubiquitin-proteasome system and chaperones, could also have effects on neurodegenerative disorders. We aimed to critically analyze the available findings regarding the neurobiological implications of proteostasis on the development of neurodegenerative and psychiatric diseases, considering the mitochondrial role. Proteostasis alterations in the prefrontal cortex implicate proteome instability and accumulation of misfolded proteins. Altered mitochondrial dynamics, especially in proteostasis processes, could impede the normal compensatory mechanisms against cell damage. Thereby, altered mitochondrial functions on regulatory modulation of dendritic development, neuroinflammation, and respiratory function may underlie the development of some psychiatric conditions, such as schizophrenia, being influenced by a genetic background. It is expected that with the increasing evidence about proteostasis in neuropsychiatric disorders, new therapeutic alternatives will emerge. |
| format | Article |
| id | doaj-art-aad9e8f995c6493ebf5547389c4290fe |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-aad9e8f995c6493ebf5547389c4290fe2025-02-03T01:29:23ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/67987126798712Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current PerspectivesPablo Olivero0Carlo Lozano1Ramón Sotomayor-Zárate2Nicolás Meza-Concha3Marcelo Arancibia4Claudio Córdova5Wilfredo González-Arriagada6Ricardo Ramírez-Barrantes7Ivanny Marchant8Laboratorio de Estructura y Función Celular, Escuela de Medicina, Facultad de Medicina, Universidad de Valparaíso, Hontaneda 2664, 2341386 Valparaíso, ChileLaboratorio de Estructura y Función Celular, Escuela de Medicina, Facultad de Medicina, Universidad de Valparaíso, Hontaneda 2664, 2341386 Valparaíso, ChileLaboratorio de Neuroquímica y Neurofarmacología, Centro de Neurobiología y Fisiopatología Integrativa, Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, ChileLaboratorio de Estructura y Función Celular, Escuela de Medicina, Facultad de Medicina, Universidad de Valparaíso, Hontaneda 2664, 2341386 Valparaíso, ChileLaboratorio de Estructura y Función Celular, Escuela de Medicina, Facultad de Medicina, Universidad de Valparaíso, Hontaneda 2664, 2341386 Valparaíso, ChileLaboratorio de Estructura y Función Celular, Escuela de Medicina, Facultad de Medicina, Universidad de Valparaíso, Hontaneda 2664, 2341386 Valparaíso, ChileCentro Interoperativo en Ciencias Odontológicas y Médicas, Universidad de Valparaíso, Valparaíso, ChileEscuela de Tecnologia Medica, Universidad Andres Bello, Quillota 980, 2531015 Viña del Mar, ChileLaboratorio de Estructura y Función Celular, Escuela de Medicina, Facultad de Medicina, Universidad de Valparaíso, Hontaneda 2664, 2341386 Valparaíso, ChileProteostasis involves processes that are fundamental for neural viability. Thus, protein misfolding and the formation of toxic aggregates at neural level, secondary to dysregulation of the conservative mechanisms of proteostasis, are associated with several neuropsychiatric conditions. It has been observed that impaired mitochondrial function due to a dysregulated proteostasis control system, that is, ubiquitin-proteasome system and chaperones, could also have effects on neurodegenerative disorders. We aimed to critically analyze the available findings regarding the neurobiological implications of proteostasis on the development of neurodegenerative and psychiatric diseases, considering the mitochondrial role. Proteostasis alterations in the prefrontal cortex implicate proteome instability and accumulation of misfolded proteins. Altered mitochondrial dynamics, especially in proteostasis processes, could impede the normal compensatory mechanisms against cell damage. Thereby, altered mitochondrial functions on regulatory modulation of dendritic development, neuroinflammation, and respiratory function may underlie the development of some psychiatric conditions, such as schizophrenia, being influenced by a genetic background. It is expected that with the increasing evidence about proteostasis in neuropsychiatric disorders, new therapeutic alternatives will emerge.http://dx.doi.org/10.1155/2018/6798712 |
| spellingShingle | Pablo Olivero Carlo Lozano Ramón Sotomayor-Zárate Nicolás Meza-Concha Marcelo Arancibia Claudio Córdova Wilfredo González-Arriagada Ricardo Ramírez-Barrantes Ivanny Marchant Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives Neural Plasticity |
| title | Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives |
| title_full | Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives |
| title_fullStr | Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives |
| title_full_unstemmed | Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives |
| title_short | Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives |
| title_sort | proteostasis and mitochondrial role on psychiatric and neurodegenerative disorders current perspectives |
| url | http://dx.doi.org/10.1155/2018/6798712 |
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