Colorectal cancer biomarkers and their impact on the clinical practice
Colorectal cancer (CRC) holds third place in the global ranking of malignancies worldwide. Patients with CRC commonly show distinct outcomes and treatment responses due to their biological features and tumoral biomarkers. This review explores the repertoire of molecular biomarkers in CRC, comprised...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2021-10-01
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| Series: | Brazilian Journal of Oncology |
| Subjects: | |
| Online Access: | http://www.brazilianjournalofoncology.com.br/details/172/en-US/colorectal-cancer-biomarkers-and-their-impact-on-the-clinical-practice |
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| _version_ | 1849766595527704576 |
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| author | James Crespo Ana Paula Victorino Kelly Araujo Luiz Henrique Araujo Fernando Meton de Alencar Camara Vieira |
| author_facet | James Crespo Ana Paula Victorino Kelly Araujo Luiz Henrique Araujo Fernando Meton de Alencar Camara Vieira |
| author_sort | James Crespo |
| collection | DOAJ |
| description | Colorectal cancer (CRC) holds third place in the global ranking of malignancies worldwide. Patients with CRC commonly show distinct outcomes and treatment responses due to their biological features and tumoral biomarkers. This review explores the repertoire of molecular biomarkers in CRC, comprised of chromosomal aberrations and genomic instability and genetic mutations. We also underline the stratification of CRC patients into four clinically defined subsets: CMS1 (MSI, immune); CMS2 (canonical); CMS3 (metabolic); and CMS4 (mesenchymal), as well as novel techniques to be applied very soon in the field, such as cell-free DNA, tumor mutational burden, and microbiome profiling. |
| format | Article |
| id | doaj-art-aace504e48814da2a733916c71af7c47 |
| institution | DOAJ |
| issn | 2526-8732 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Brazilian Journal of Oncology |
| spelling | doaj-art-aace504e48814da2a733916c71af7c472025-08-20T03:04:31ZengThieme Revinter Publicações Ltda.Brazilian Journal of Oncology2526-87322021-10-01170010.5935/2526-8732.20210025Colorectal cancer biomarkers and their impact on the clinical practiceJames Crespo0Ana Paula Victorino1Kelly Araujo2Luiz Henrique Araujo3Fernando Meton de Alencar Camara Vieira4Americas Centro de Oncologia Integrado, Medical Oncology - Rio de Janeiro - RJ - BrazilAmericas Centro de Oncologia Integrado, Medical Oncology - Rio de Janeiro - RJ - BrazilAmericas Centro de Oncologia Integrado, Medical Oncology - Rio de Janeiro - RJ - BrazilAmericas Centro de Oncologia Integrado, Medical Oncology - Rio de Janeiro - RJ - BrazilAmericas Centro de Oncologia Integrado, Medical Oncology - Rio de Janeiro - RJ - BrazilColorectal cancer (CRC) holds third place in the global ranking of malignancies worldwide. Patients with CRC commonly show distinct outcomes and treatment responses due to their biological features and tumoral biomarkers. This review explores the repertoire of molecular biomarkers in CRC, comprised of chromosomal aberrations and genomic instability and genetic mutations. We also underline the stratification of CRC patients into four clinically defined subsets: CMS1 (MSI, immune); CMS2 (canonical); CMS3 (metabolic); and CMS4 (mesenchymal), as well as novel techniques to be applied very soon in the field, such as cell-free DNA, tumor mutational burden, and microbiome profiling.http://www.brazilianjournalofoncology.com.br/details/172/en-US/colorectal-cancer-biomarkers-and-their-impact-on-the-clinical-practicebiomarcadoresgenômicaprognósticoagentes antineoplásicosneoplasias colorretais |
| spellingShingle | James Crespo Ana Paula Victorino Kelly Araujo Luiz Henrique Araujo Fernando Meton de Alencar Camara Vieira Colorectal cancer biomarkers and their impact on the clinical practice Brazilian Journal of Oncology biomarcadores genômica prognóstico agentes antineoplásicos neoplasias colorretais |
| title | Colorectal cancer biomarkers and their impact on the clinical practice |
| title_full | Colorectal cancer biomarkers and their impact on the clinical practice |
| title_fullStr | Colorectal cancer biomarkers and their impact on the clinical practice |
| title_full_unstemmed | Colorectal cancer biomarkers and their impact on the clinical practice |
| title_short | Colorectal cancer biomarkers and their impact on the clinical practice |
| title_sort | colorectal cancer biomarkers and their impact on the clinical practice |
| topic | biomarcadores genômica prognóstico agentes antineoplásicos neoplasias colorretais |
| url | http://www.brazilianjournalofoncology.com.br/details/172/en-US/colorectal-cancer-biomarkers-and-their-impact-on-the-clinical-practice |
| work_keys_str_mv | AT jamescrespo colorectalcancerbiomarkersandtheirimpactontheclinicalpractice AT anapaulavictorino colorectalcancerbiomarkersandtheirimpactontheclinicalpractice AT kellyaraujo colorectalcancerbiomarkersandtheirimpactontheclinicalpractice AT luizhenriquearaujo colorectalcancerbiomarkersandtheirimpactontheclinicalpractice AT fernandometondealencarcamaravieira colorectalcancerbiomarkersandtheirimpactontheclinicalpractice |