Interaction among Cells of Bone, Immune System, and Solid Tumors Leads to Bone Metastases
Bone metastases are a dismal consequence for different types of solid tumors, such as breast, prostate, lung, and kidney cancer. The mechanisms regulating the interactions among bone, immune system, and tumor cells have been deeply investigated, and many studies are ongoing to define the specific r...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/315024 |
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| _version_ | 1832558678487597056 |
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| author | Ilaria Roato |
| author_facet | Ilaria Roato |
| author_sort | Ilaria Roato |
| collection | DOAJ |
| description | Bone metastases are a dismal consequence for different types of solid tumors, such as breast, prostate, lung, and kidney cancer. The mechanisms regulating the interactions among bone, immune system, and tumor cells have been deeply investigated, and many studies are ongoing to define the specific role of the different cells in the bone metastatic process. The affinity of some tumors to growth in bone results from the special microenvironment provided by bone. Moreover, immune system and bone have a bidirectional relationship: bone cells express surface molecules ruling the expansion of hemopoietic stem cells from which all cells of the mammalian immune system derive, and various immunoregulatory cytokines influence the fate of bone cells. The last findings allow to extend the concept of vicious cycle and add T cells as mediators of the tumor growth in bone. |
| format | Article |
| id | doaj-art-aacde48f514c430badfb90a90e80360e |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-aacde48f514c430badfb90a90e80360e2025-02-03T01:31:50ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/315024315024Interaction among Cells of Bone, Immune System, and Solid Tumors Leads to Bone MetastasesIlaria Roato0CeRMS, A.O. Città della Salute e della Scienza, Via Santena 5, 10126 Torino, ItalyBone metastases are a dismal consequence for different types of solid tumors, such as breast, prostate, lung, and kidney cancer. The mechanisms regulating the interactions among bone, immune system, and tumor cells have been deeply investigated, and many studies are ongoing to define the specific role of the different cells in the bone metastatic process. The affinity of some tumors to growth in bone results from the special microenvironment provided by bone. Moreover, immune system and bone have a bidirectional relationship: bone cells express surface molecules ruling the expansion of hemopoietic stem cells from which all cells of the mammalian immune system derive, and various immunoregulatory cytokines influence the fate of bone cells. The last findings allow to extend the concept of vicious cycle and add T cells as mediators of the tumor growth in bone.http://dx.doi.org/10.1155/2013/315024 |
| spellingShingle | Ilaria Roato Interaction among Cells of Bone, Immune System, and Solid Tumors Leads to Bone Metastases Clinical and Developmental Immunology |
| title | Interaction among Cells of Bone, Immune System, and Solid Tumors Leads to Bone Metastases |
| title_full | Interaction among Cells of Bone, Immune System, and Solid Tumors Leads to Bone Metastases |
| title_fullStr | Interaction among Cells of Bone, Immune System, and Solid Tumors Leads to Bone Metastases |
| title_full_unstemmed | Interaction among Cells of Bone, Immune System, and Solid Tumors Leads to Bone Metastases |
| title_short | Interaction among Cells of Bone, Immune System, and Solid Tumors Leads to Bone Metastases |
| title_sort | interaction among cells of bone immune system and solid tumors leads to bone metastases |
| url | http://dx.doi.org/10.1155/2013/315024 |
| work_keys_str_mv | AT ilariaroato interactionamongcellsofboneimmunesystemandsolidtumorsleadstobonemetastases |