COMPARISON OF PRESEPSIN, PROCALCITONIN, INTERLEUKIN-8 AND C-REACTIVE PROTEIN IN PREDICTING BACTERAEMIA IN FEBRILE NEUTROPENIC ADULT PATIENTS WITH HAEMATOLOGICAL MALIGNANCIES
Bacterial infections represent life-threatening complications in patients with febrile neutropenia (FN). Biomarkers of infections may help to differentiate bacteraemia from non-bacteraemia FN. We aimed to evaluate the utility of procalcitonin (PCT), presepsin (PS), C-reactive protein (CRP) and inter...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2019-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Online Access: | http://mjhid.org/index.php/mjhid/article/view/3944 |
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| author | Irena Kostic Carmela Gurrieri Elisa Piva Gianpietro Semenzato Mario Plebani Ilaria Caputo Fabrizio Vianello |
| author_facet | Irena Kostic Carmela Gurrieri Elisa Piva Gianpietro Semenzato Mario Plebani Ilaria Caputo Fabrizio Vianello |
| author_sort | Irena Kostic |
| collection | DOAJ |
| description | Bacterial infections represent life-threatening complications in patients with febrile neutropenia (FN). Biomarkers of infections may help to differentiate bacteraemia from non-bacteraemia FN. We aimed to evaluate the utility of procalcitonin (PCT), presepsin (PS), C-reactive protein (CRP) and interleukin-8 (IL-8) as biomarkers of bacteraemia in adult FN patients with haematological malignancies. Thirty-six FN episodes experienced by 28 oncohematological patients were considered. 11 out of 36 episodes were classified as bacteraemia. PCT was the best biomarker to predict bacteraemia with area under the curve (AUC) ROC of 0,9; while the most sensitive was IL-8 (90,9%) with AUC ROC of 0,88. All patients with PCT concentrations above 1,6 μg/l had bacteraemia. Patients with IL-8 concentrations > 170 pg/ml or PS concentrations superior then 410 pg/ml had 40 times and 24 times higher risk for bacteraemia, respectively. PCT remains better than IL-8 and PS in predicting bacteraemia in adult hematological patients with FN. |
| format | Article |
| id | doaj-art-aac87894a6c54a50bcb70b1bbc375f8e |
| institution | DOAJ |
| issn | 2035-3006 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-aac87894a6c54a50bcb70b1bbc375f8e2025-08-20T02:58:44ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062019-08-0111110.4084/mjhid.2019.047COMPARISON OF PRESEPSIN, PROCALCITONIN, INTERLEUKIN-8 AND C-REACTIVE PROTEIN IN PREDICTING BACTERAEMIA IN FEBRILE NEUTROPENIC ADULT PATIENTS WITH HAEMATOLOGICAL MALIGNANCIESIrena Kostic0Carmela Gurrieri1Elisa Piva2Gianpietro Semenzato3Mario Plebani4Ilaria Caputo5Fabrizio Vianello6Department of Medicine, University of Padova, ItalyDepartment of Medicine, University of Padua School of Medicine, Padova, ItalyDepartment of Laboratory Medicine, Department of Medicine, University of Padua School of Medicine, Padova, ItalyDepartment of Medicine, University of Padua School of Medicine, Padova, ItalyDepartment of Laboratory Medicine; Department of Medicine, University of Padua School of Medicine, Padova, ItalyDepartment of Medicine, University of Padua School of Medicine, Padova, ItalyUniversity of PadovaBacterial infections represent life-threatening complications in patients with febrile neutropenia (FN). Biomarkers of infections may help to differentiate bacteraemia from non-bacteraemia FN. We aimed to evaluate the utility of procalcitonin (PCT), presepsin (PS), C-reactive protein (CRP) and interleukin-8 (IL-8) as biomarkers of bacteraemia in adult FN patients with haematological malignancies. Thirty-six FN episodes experienced by 28 oncohematological patients were considered. 11 out of 36 episodes were classified as bacteraemia. PCT was the best biomarker to predict bacteraemia with area under the curve (AUC) ROC of 0,9; while the most sensitive was IL-8 (90,9%) with AUC ROC of 0,88. All patients with PCT concentrations above 1,6 μg/l had bacteraemia. Patients with IL-8 concentrations > 170 pg/ml or PS concentrations superior then 410 pg/ml had 40 times and 24 times higher risk for bacteraemia, respectively. PCT remains better than IL-8 and PS in predicting bacteraemia in adult hematological patients with FN.http://mjhid.org/index.php/mjhid/article/view/3944 |
| spellingShingle | Irena Kostic Carmela Gurrieri Elisa Piva Gianpietro Semenzato Mario Plebani Ilaria Caputo Fabrizio Vianello COMPARISON OF PRESEPSIN, PROCALCITONIN, INTERLEUKIN-8 AND C-REACTIVE PROTEIN IN PREDICTING BACTERAEMIA IN FEBRILE NEUTROPENIC ADULT PATIENTS WITH HAEMATOLOGICAL MALIGNANCIES Mediterranean Journal of Hematology and Infectious Diseases |
| title | COMPARISON OF PRESEPSIN, PROCALCITONIN, INTERLEUKIN-8 AND C-REACTIVE PROTEIN IN PREDICTING BACTERAEMIA IN FEBRILE NEUTROPENIC ADULT PATIENTS WITH HAEMATOLOGICAL MALIGNANCIES |
| title_full | COMPARISON OF PRESEPSIN, PROCALCITONIN, INTERLEUKIN-8 AND C-REACTIVE PROTEIN IN PREDICTING BACTERAEMIA IN FEBRILE NEUTROPENIC ADULT PATIENTS WITH HAEMATOLOGICAL MALIGNANCIES |
| title_fullStr | COMPARISON OF PRESEPSIN, PROCALCITONIN, INTERLEUKIN-8 AND C-REACTIVE PROTEIN IN PREDICTING BACTERAEMIA IN FEBRILE NEUTROPENIC ADULT PATIENTS WITH HAEMATOLOGICAL MALIGNANCIES |
| title_full_unstemmed | COMPARISON OF PRESEPSIN, PROCALCITONIN, INTERLEUKIN-8 AND C-REACTIVE PROTEIN IN PREDICTING BACTERAEMIA IN FEBRILE NEUTROPENIC ADULT PATIENTS WITH HAEMATOLOGICAL MALIGNANCIES |
| title_short | COMPARISON OF PRESEPSIN, PROCALCITONIN, INTERLEUKIN-8 AND C-REACTIVE PROTEIN IN PREDICTING BACTERAEMIA IN FEBRILE NEUTROPENIC ADULT PATIENTS WITH HAEMATOLOGICAL MALIGNANCIES |
| title_sort | comparison of presepsin procalcitonin interleukin 8 and c reactive protein in predicting bacteraemia in febrile neutropenic adult patients with haematological malignancies |
| url | http://mjhid.org/index.php/mjhid/article/view/3944 |
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