Thalamo-cortical neural mechanism of sodium salicylate-induced hyperacusis and anxiety-like behaviors
Abstract Tinnitus has been identified as a potential contributor to anxiety. Thalamo-cortical pathway plays a crucial role in the transmission of auditory and emotional information, but its casual link to tinnitus-associated anxiety remains unclear. In this study, we explore the neural activities in...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-10-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07040-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850181997613285376 |
|---|---|
| author | Jingyu Chen Xueru Wang Zijie Li Hui Yuan Xuejiao Wang Yang Yun Xu Wu Pingting Yang Ling Qin |
| author_facet | Jingyu Chen Xueru Wang Zijie Li Hui Yuan Xuejiao Wang Yang Yun Xu Wu Pingting Yang Ling Qin |
| author_sort | Jingyu Chen |
| collection | DOAJ |
| description | Abstract Tinnitus has been identified as a potential contributor to anxiety. Thalamo-cortical pathway plays a crucial role in the transmission of auditory and emotional information, but its casual link to tinnitus-associated anxiety remains unclear. In this study, we explore the neural activities in the thalamus and cortex of the sodium salicylate (NaSal)-treated mice, which exhibit both hyperacusis and anxiety-like behaviors. We find an increase in gamma band oscillations (GBO) in both auditory cortex (AC) and prefrontal cortex (PFC), as well as phase-locking between cortical GBO and thalamic neural activity. These changes are attributable to a suppression of GABAergic neuron activity in thalamic reticular nucleus (TRN), and optogenetic activation of TRN reduces NaSal-induced hyperacusis and anxiety-like behaviors. The elevation of endocannabinoid (eCB)/ cannabinoid receptor 1 (CB1R) transmission in TRN contributes to the NaSal-induced abnormalities. Our results highlight the regulative role of TRN in the auditory and limbic thalamic-cortical pathways. |
| format | Article |
| id | doaj-art-aabaa1b579dc4bcaad3fe5886b785a0c |
| institution | OA Journals |
| issn | 2399-3642 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-aabaa1b579dc4bcaad3fe5886b785a0c2025-08-20T02:17:46ZengNature PortfolioCommunications Biology2399-36422024-10-017111710.1038/s42003-024-07040-5Thalamo-cortical neural mechanism of sodium salicylate-induced hyperacusis and anxiety-like behaviorsJingyu Chen0Xueru Wang1Zijie Li2Hui Yuan3Xuejiao Wang4Yang Yun5Xu Wu6Pingting Yang7Ling Qin8Department of Physiology, School of Life Sciences, China Medical UniversityLaboratory of Hearing Research, School of Life Sciences, China Medical UniversityDepartment of Physiology, School of Life Sciences, China Medical UniversityLaboratory of Hearing Research, School of Life Sciences, China Medical UniversityDepartment of Physiology, School of Life Sciences, China Medical UniversityDepartment of Nephrology, Shengjing Hospital of China Medical UniversityDepartment of Forensic Pathology, China Medical University School of Forensic MedicineDepartment of Rheumatology and Immunology, The First Hospital of China Medical UniversityLaboratory of Hearing Research, School of Life Sciences, China Medical UniversityAbstract Tinnitus has been identified as a potential contributor to anxiety. Thalamo-cortical pathway plays a crucial role in the transmission of auditory and emotional information, but its casual link to tinnitus-associated anxiety remains unclear. In this study, we explore the neural activities in the thalamus and cortex of the sodium salicylate (NaSal)-treated mice, which exhibit both hyperacusis and anxiety-like behaviors. We find an increase in gamma band oscillations (GBO) in both auditory cortex (AC) and prefrontal cortex (PFC), as well as phase-locking between cortical GBO and thalamic neural activity. These changes are attributable to a suppression of GABAergic neuron activity in thalamic reticular nucleus (TRN), and optogenetic activation of TRN reduces NaSal-induced hyperacusis and anxiety-like behaviors. The elevation of endocannabinoid (eCB)/ cannabinoid receptor 1 (CB1R) transmission in TRN contributes to the NaSal-induced abnormalities. Our results highlight the regulative role of TRN in the auditory and limbic thalamic-cortical pathways.https://doi.org/10.1038/s42003-024-07040-5 |
| spellingShingle | Jingyu Chen Xueru Wang Zijie Li Hui Yuan Xuejiao Wang Yang Yun Xu Wu Pingting Yang Ling Qin Thalamo-cortical neural mechanism of sodium salicylate-induced hyperacusis and anxiety-like behaviors Communications Biology |
| title | Thalamo-cortical neural mechanism of sodium salicylate-induced hyperacusis and anxiety-like behaviors |
| title_full | Thalamo-cortical neural mechanism of sodium salicylate-induced hyperacusis and anxiety-like behaviors |
| title_fullStr | Thalamo-cortical neural mechanism of sodium salicylate-induced hyperacusis and anxiety-like behaviors |
| title_full_unstemmed | Thalamo-cortical neural mechanism of sodium salicylate-induced hyperacusis and anxiety-like behaviors |
| title_short | Thalamo-cortical neural mechanism of sodium salicylate-induced hyperacusis and anxiety-like behaviors |
| title_sort | thalamo cortical neural mechanism of sodium salicylate induced hyperacusis and anxiety like behaviors |
| url | https://doi.org/10.1038/s42003-024-07040-5 |
| work_keys_str_mv | AT jingyuchen thalamocorticalneuralmechanismofsodiumsalicylateinducedhyperacusisandanxietylikebehaviors AT xueruwang thalamocorticalneuralmechanismofsodiumsalicylateinducedhyperacusisandanxietylikebehaviors AT zijieli thalamocorticalneuralmechanismofsodiumsalicylateinducedhyperacusisandanxietylikebehaviors AT huiyuan thalamocorticalneuralmechanismofsodiumsalicylateinducedhyperacusisandanxietylikebehaviors AT xuejiaowang thalamocorticalneuralmechanismofsodiumsalicylateinducedhyperacusisandanxietylikebehaviors AT yangyun thalamocorticalneuralmechanismofsodiumsalicylateinducedhyperacusisandanxietylikebehaviors AT xuwu thalamocorticalneuralmechanismofsodiumsalicylateinducedhyperacusisandanxietylikebehaviors AT pingtingyang thalamocorticalneuralmechanismofsodiumsalicylateinducedhyperacusisandanxietylikebehaviors AT lingqin thalamocorticalneuralmechanismofsodiumsalicylateinducedhyperacusisandanxietylikebehaviors |