Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review
A subset of children and adolescents experience recurrent or persistent symptoms following SARS-CoV-2 infection, known as postacute sequelae of COVID-19 (PASC), however, the clinical epidemiology within the United States (US) is not yet well understood. This scoping review aims to synthesize the cli...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | American Journal of Medicine Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667036424000153 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850060759039475712 |
|---|---|
| author | Christine M. Miller Carla Borre Alex Green Melissa Funaro Carlos R Oliveira Akiko Iwasaki |
| author_facet | Christine M. Miller Carla Borre Alex Green Melissa Funaro Carlos R Oliveira Akiko Iwasaki |
| author_sort | Christine M. Miller |
| collection | DOAJ |
| description | A subset of children and adolescents experience recurrent or persistent symptoms following SARS-CoV-2 infection, known as postacute sequelae of COVID-19 (PASC), however, the clinical epidemiology within the United States (US) is not yet well understood. This scoping review aims to synthesize the clinical epidemiology of pediatric PASC in the US. A comprehensive literature search was conducted and databases were queried from inception until January 29, 2024. Studies including US children and adolescents <21 years old were considered. From 1028 studies identified, 29 met the inclusion criteria. Prevalence of PASC ranged from less than 1%-27%. Risk factors included older age, female sex, asthma, obesity, and severe initial infection. Common symptoms were dyspnea, fatigue, headaches, and chest pain. A multidisciplinary approach for diagnosis and management was common across studies. Most studies had a high risk of bias and were limited by a lack of standardized definitions and short follow-up duration. This review establishes a foundation for understanding pediatric PASC and highlights the critical need for continued research to optimize prevention and treatment strategies. |
| format | Article |
| id | doaj-art-aaabb9265c62483eab127855a7019f9d |
| institution | DOAJ |
| issn | 2667-0364 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Medicine Open |
| spelling | doaj-art-aaabb9265c62483eab127855a7019f9d2025-08-20T02:50:27ZengElsevierAmerican Journal of Medicine Open2667-03642024-12-011210007810.1016/j.ajmo.2024.100078Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping ReviewChristine M. Miller0Carla Borre1Alex Green2Melissa Funaro3Carlos R Oliveira4Akiko Iwasaki5Department of Pediatrics, Division of Infectious Diseases and Global Health, Yale University School of Medicine New Haven, New Haven, CTDepartment of Pediatrics, Division of Infectious Diseases and Global Health, Yale University School of Medicine New Haven, New Haven, CTDepartment of Pediatrics, Division of Infectious Diseases and Global Health, Yale University School of Medicine New Haven, New Haven, CTHarvey Cushing/John Hay Whitney Medical Library, Yale University, New Haven, CTDepartment of Pediatrics, Division of Infectious Diseases and Global Health, Yale University School of Medicine New Haven, New Haven, CTDepartment of Immunobiology, Yale School of Medicine, New Haven, CT; Howard Hughes Medical Institute, Chevy Chase, MD; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT; Requests for reprints should be addressed to Akiko Iwasaki, 300 Cedar Street, TAC S-655B, New Haven, CT 06520.A subset of children and adolescents experience recurrent or persistent symptoms following SARS-CoV-2 infection, known as postacute sequelae of COVID-19 (PASC), however, the clinical epidemiology within the United States (US) is not yet well understood. This scoping review aims to synthesize the clinical epidemiology of pediatric PASC in the US. A comprehensive literature search was conducted and databases were queried from inception until January 29, 2024. Studies including US children and adolescents <21 years old were considered. From 1028 studies identified, 29 met the inclusion criteria. Prevalence of PASC ranged from less than 1%-27%. Risk factors included older age, female sex, asthma, obesity, and severe initial infection. Common symptoms were dyspnea, fatigue, headaches, and chest pain. A multidisciplinary approach for diagnosis and management was common across studies. Most studies had a high risk of bias and were limited by a lack of standardized definitions and short follow-up duration. This review establishes a foundation for understanding pediatric PASC and highlights the critical need for continued research to optimize prevention and treatment strategies.http://www.sciencedirect.com/science/article/pii/S2667036424000153Long COVIDPostacute sequelae of COVID-19 (PASC)Pediatric |
| spellingShingle | Christine M. Miller Carla Borre Alex Green Melissa Funaro Carlos R Oliveira Akiko Iwasaki Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review American Journal of Medicine Open Long COVID Postacute sequelae of COVID-19 (PASC) Pediatric |
| title | Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review |
| title_full | Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review |
| title_fullStr | Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review |
| title_full_unstemmed | Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review |
| title_short | Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review |
| title_sort | postacute sequelae of covid 19 in pediatric patients within the united states a scoping review |
| topic | Long COVID Postacute sequelae of COVID-19 (PASC) Pediatric |
| url | http://www.sciencedirect.com/science/article/pii/S2667036424000153 |
| work_keys_str_mv | AT christinemmiller postacutesequelaeofcovid19inpediatricpatientswithintheunitedstatesascopingreview AT carlaborre postacutesequelaeofcovid19inpediatricpatientswithintheunitedstatesascopingreview AT alexgreen postacutesequelaeofcovid19inpediatricpatientswithintheunitedstatesascopingreview AT melissafunaro postacutesequelaeofcovid19inpediatricpatientswithintheunitedstatesascopingreview AT carlosroliveira postacutesequelaeofcovid19inpediatricpatientswithintheunitedstatesascopingreview AT akikoiwasaki postacutesequelaeofcovid19inpediatricpatientswithintheunitedstatesascopingreview |