Early postnatal exposure to bicuculline modulates E/I balance and induces ASD-like behavioral phenotypes in mice

Early postnatal exposure to bicuculline modulates E/I balance and induces ASD-like behavioral phenotypes in mice

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social interaction deficits and repetitive behaviors. While precise causes of ASD remain elusive, growing evidence highlights that an imbalance in excitatory and inhibitory (E/I) signaling is a pivotal factor in ASD de...

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Bibliographic Details
Main Authors: Dongpil Shin, Eunbi Cho, Kwanghoon Park, ChiHye Chung, Dong Hyun Kim, Se Jin Jeon, Chan Young Shin
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Animal Cells and Systems
Subjects:
Autism spectrum disorder
bicuculline
E/I imbalance
synaptic vesicle
animal model
Online Access:https://www.tandfonline.com/doi/10.1080/19768354.2025.2493258
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https://www.tandfonline.com/doi/10.1080/19768354.2025.2493258

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