Biosynthesis of conjugated linoleic acid: current status and future perspectives
Abstract Conjugated linoleic acid (CLA) has received much attention for its beneficial physiological effects, particularly anticancer and metabolic control activity. However, traditional sources rely on extraction and chemical synthesis, both of which are not commercially viable. This article descri...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-07-01
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| Series: | Bioresources and Bioprocessing |
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| Online Access: | https://doi.org/10.1186/s40643-025-00911-7 |
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| author | Lu Lin Mei-Li Sun Kaifeng Wang Jian Gao Xiao-Jun Ji Quanyu Zhao |
| author_facet | Lu Lin Mei-Li Sun Kaifeng Wang Jian Gao Xiao-Jun Ji Quanyu Zhao |
| author_sort | Lu Lin |
| collection | DOAJ |
| description | Abstract Conjugated linoleic acid (CLA) has received much attention for its beneficial physiological effects, particularly anticancer and metabolic control activity. However, traditional sources rely on extraction and chemical synthesis, both of which are not commercially viable. This article describes the research progress on sustainable alternative biosynthesis methods for the production of CLA, which is an attractive approach for commercial production because of its high stereoselectivity and convenient purification process. Here, we offer a comprehensive review of the current state and research progress in the biosynthesis of CLA, including production strains, biosynthesis mechanisms and improvements in the biosynthesis of CLA by genetic engineering. Finally, future research directions for improving the biosynthesis of CLA are defined in the light of recent advances, barriers and trends in this field. |
| format | Article |
| id | doaj-art-aaaab2be1b3345d2845e67c7166e8e91 |
| institution | Kabale University |
| issn | 2197-4365 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bioresources and Bioprocessing |
| spelling | doaj-art-aaaab2be1b3345d2845e67c7166e8e912025-08-20T04:01:42ZengSpringerOpenBioresources and Bioprocessing2197-43652025-07-0112111210.1186/s40643-025-00911-7Biosynthesis of conjugated linoleic acid: current status and future perspectivesLu Lin0Mei-Li Sun1Kaifeng Wang2Jian Gao3Xiao-Jun Ji4Quanyu Zhao5State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech UniversityState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech UniversityState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech UniversitySchool of Marine and Bioengineering, Yancheng Institute of TechnologyState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech UniversitySchool of Pharmaceutical Sciences, Nanjing Tech UniversityAbstract Conjugated linoleic acid (CLA) has received much attention for its beneficial physiological effects, particularly anticancer and metabolic control activity. However, traditional sources rely on extraction and chemical synthesis, both of which are not commercially viable. This article describes the research progress on sustainable alternative biosynthesis methods for the production of CLA, which is an attractive approach for commercial production because of its high stereoselectivity and convenient purification process. Here, we offer a comprehensive review of the current state and research progress in the biosynthesis of CLA, including production strains, biosynthesis mechanisms and improvements in the biosynthesis of CLA by genetic engineering. Finally, future research directions for improving the biosynthesis of CLA are defined in the light of recent advances, barriers and trends in this field.https://doi.org/10.1186/s40643-025-00911-7Conjugated Linoleic acidLinoleic acid isomeraseBiotransformationDe Novo biosynthesisSynthetic biology |
| spellingShingle | Lu Lin Mei-Li Sun Kaifeng Wang Jian Gao Xiao-Jun Ji Quanyu Zhao Biosynthesis of conjugated linoleic acid: current status and future perspectives Bioresources and Bioprocessing Conjugated Linoleic acid Linoleic acid isomerase Biotransformation De Novo biosynthesis Synthetic biology |
| title | Biosynthesis of conjugated linoleic acid: current status and future perspectives |
| title_full | Biosynthesis of conjugated linoleic acid: current status and future perspectives |
| title_fullStr | Biosynthesis of conjugated linoleic acid: current status and future perspectives |
| title_full_unstemmed | Biosynthesis of conjugated linoleic acid: current status and future perspectives |
| title_short | Biosynthesis of conjugated linoleic acid: current status and future perspectives |
| title_sort | biosynthesis of conjugated linoleic acid current status and future perspectives |
| topic | Conjugated Linoleic acid Linoleic acid isomerase Biotransformation De Novo biosynthesis Synthetic biology |
| url | https://doi.org/10.1186/s40643-025-00911-7 |
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