The Prospects for the Therapeutic Implications of Genetically Engineered Probiotics
The interest in the therapeutic use of probiotic microorganisms has been increased during the last decade although the doubts have ascended about the probiotics mainly because their beneficial effects are not fully understood, and, in many cases, their usefulness has not been validated in clinical t...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Food Quality |
| Online Access: | http://dx.doi.org/10.1155/2020/9676452 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547031203184640 |
|---|---|
| author | Sayyeda Farwa Mazhar Muhammad Afzal Ahmad Almatroudi Samman Munir Usman Ali Ashfaq Maria Rasool Hammad Raza Hafiz Muhammad Waqas Munir Muhammad Shahid Riaz Rajoka Mohsin Khurshid |
| author_facet | Sayyeda Farwa Mazhar Muhammad Afzal Ahmad Almatroudi Samman Munir Usman Ali Ashfaq Maria Rasool Hammad Raza Hafiz Muhammad Waqas Munir Muhammad Shahid Riaz Rajoka Mohsin Khurshid |
| author_sort | Sayyeda Farwa Mazhar |
| collection | DOAJ |
| description | The interest in the therapeutic use of probiotic microorganisms has been increased during the last decade although the doubts have ascended about the probiotics mainly because their beneficial effects are not fully understood, and, in many cases, their usefulness has not been validated in clinical trials. Consequently, the notion got a considerable interest in those strains having proven probiotic potential to be engineered for improvement in their beneficial features. The process of genetic engineering can also be used for probiotic strains for the reversion of antimicrobial resistance and other modifications for their safer and effective human applications. The lactic acid bacilli are predominantly opposite as they already have gained attention owing to their health-promoting benefits and their safety for human consumption; therefore, their use, especially as a delivery agent of vaccines and drugs, is gaining attention. The tailoring of probiotic strains will not only improve the data regarding the probiotic potential of these strains but also clinch the doubts concerning these probiotics. This article focuses on the approaches of bioengineered probiotics and discusses the potential prospects for their therapeutic applications including immunomodulation, cognitive health, and anticancer therapeutics. |
| format | Article |
| id | doaj-art-aaa7eaf94e784fafb7acf9128c3ce7c1 |
| institution | Kabale University |
| issn | 0146-9428 1745-4557 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Food Quality |
| spelling | doaj-art-aaa7eaf94e784fafb7acf9128c3ce7c12025-02-03T06:46:24ZengWileyJournal of Food Quality0146-94281745-45572020-01-01202010.1155/2020/96764529676452The Prospects for the Therapeutic Implications of Genetically Engineered ProbioticsSayyeda Farwa Mazhar0Muhammad Afzal1Ahmad Almatroudi2Samman Munir3Usman Ali Ashfaq4Maria Rasool5Hammad Raza6Hafiz Muhammad Waqas Munir7Muhammad Shahid Riaz Rajoka8Mohsin Khurshid9College of Allied Health Professionals, Directorate of Medical Sciences, Government College University Faisalabad, Faisalabad, PakistanCollege of Allied Health Professionals, Directorate of Medical Sciences, Government College University Faisalabad, Faisalabad, PakistanDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Qassim 51431, Saudi ArabiaDepartment of Bioinformatics & Biotechnology, Government College University Faisalabad, Faisalabad, PakistanDepartment of Bioinformatics & Biotechnology, Government College University Faisalabad, Faisalabad, PakistanCollege of Allied Health Professionals, Directorate of Medical Sciences, Government College University Faisalabad, Faisalabad, PakistanDepartment of Biochemistry, Government College University Faisalabad, Faisalabad, PakistanCollege of Allied Health Professionals, Directorate of Medical Sciences, Government College University Faisalabad, Faisalabad, PakistanCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, Guangdong, ChinaDepartment of Microbiology, Government College University Faisalabad, Faisalabad, PakistanThe interest in the therapeutic use of probiotic microorganisms has been increased during the last decade although the doubts have ascended about the probiotics mainly because their beneficial effects are not fully understood, and, in many cases, their usefulness has not been validated in clinical trials. Consequently, the notion got a considerable interest in those strains having proven probiotic potential to be engineered for improvement in their beneficial features. The process of genetic engineering can also be used for probiotic strains for the reversion of antimicrobial resistance and other modifications for their safer and effective human applications. The lactic acid bacilli are predominantly opposite as they already have gained attention owing to their health-promoting benefits and their safety for human consumption; therefore, their use, especially as a delivery agent of vaccines and drugs, is gaining attention. The tailoring of probiotic strains will not only improve the data regarding the probiotic potential of these strains but also clinch the doubts concerning these probiotics. This article focuses on the approaches of bioengineered probiotics and discusses the potential prospects for their therapeutic applications including immunomodulation, cognitive health, and anticancer therapeutics.http://dx.doi.org/10.1155/2020/9676452 |
| spellingShingle | Sayyeda Farwa Mazhar Muhammad Afzal Ahmad Almatroudi Samman Munir Usman Ali Ashfaq Maria Rasool Hammad Raza Hafiz Muhammad Waqas Munir Muhammad Shahid Riaz Rajoka Mohsin Khurshid The Prospects for the Therapeutic Implications of Genetically Engineered Probiotics Journal of Food Quality |
| title | The Prospects for the Therapeutic Implications of Genetically Engineered Probiotics |
| title_full | The Prospects for the Therapeutic Implications of Genetically Engineered Probiotics |
| title_fullStr | The Prospects for the Therapeutic Implications of Genetically Engineered Probiotics |
| title_full_unstemmed | The Prospects for the Therapeutic Implications of Genetically Engineered Probiotics |
| title_short | The Prospects for the Therapeutic Implications of Genetically Engineered Probiotics |
| title_sort | prospects for the therapeutic implications of genetically engineered probiotics |
| url | http://dx.doi.org/10.1155/2020/9676452 |
| work_keys_str_mv | AT sayyedafarwamazhar theprospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT muhammadafzal theprospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT ahmadalmatroudi theprospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT sammanmunir theprospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT usmanaliashfaq theprospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT mariarasool theprospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT hammadraza theprospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT hafizmuhammadwaqasmunir theprospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT muhammadshahidriazrajoka theprospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT mohsinkhurshid theprospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT sayyedafarwamazhar prospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT muhammadafzal prospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT ahmadalmatroudi prospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT sammanmunir prospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT usmanaliashfaq prospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT mariarasool prospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT hammadraza prospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT hafizmuhammadwaqasmunir prospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT muhammadshahidriazrajoka prospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics AT mohsinkhurshid prospectsforthetherapeuticimplicationsofgeneticallyengineeredprobiotics |