Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing Loss
Increased acoustic startle responses (ASR), which represent reduced uncomfortable loudness level in humans, have been reported in middle-aged C57BL/6J mice with sensorineural hearing loss. Although neural plasticity changes in the central auditory system after the peripheral lesions were suggested t...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/8169847 |
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| author | Ning Zhao Ana’am Alkharabsheh Fei Xu Wei Sun |
| author_facet | Ning Zhao Ana’am Alkharabsheh Fei Xu Wei Sun |
| author_sort | Ning Zhao |
| collection | DOAJ |
| description | Increased acoustic startle responses (ASR), which represent reduced uncomfortable loudness level in humans, have been reported in middle-aged C57BL/6J mice with sensorineural hearing loss. Although neural plasticity changes in the central auditory system after the peripheral lesions were suggested to underlie this phenomenon, the neurological cause of exaggerated ASR is still not clear. In this study, the local field potentials and firing rates of the caudal pontine reticular nucleus (PnC), which plays a major role in the ASR pathway, were recorded in 2-month- and 6-month-old C57BL/6 J mice. Consistent with our previous studies, the amplitude of ASR increased, and the threshold of ASR decreased in the 6-month-old mice after developing 20–40 dB hearing loss. The PnC response induced by high-frequency stimuli (>20 kHz) decreased in the 6-month group, whereas the PnC response induced by low-frequency stimuli (<12 kHz) showed a significant increase in the 6-month group compared to the 2-month group. The enhancement of PnC response is similar to the ASR increase found in the 6-month-old C57 mice. Our results suggest that the high-frequency hearing loss caused an increase in PnC sensitivity in the C57 mice which may enhance ASRs. |
| format | Article |
| id | doaj-art-aaa5fb8b8288452399ee0ce9dd752a07 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
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| series | Neural Plasticity |
| spelling | doaj-art-aaa5fb8b8288452399ee0ce9dd752a072025-02-03T01:33:14ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/81698478169847Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing LossNing Zhao0Ana’am Alkharabsheh1Fei Xu2Wei Sun3Department of Otolaryngology–Head and Neck Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaCenter for Hearing & Deafness, Department of Communicative Disorders and Science, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USACenter for Hearing & Deafness, Department of Communicative Disorders and Science, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USADepartment of Otolaryngology–Head and Neck Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaIncreased acoustic startle responses (ASR), which represent reduced uncomfortable loudness level in humans, have been reported in middle-aged C57BL/6J mice with sensorineural hearing loss. Although neural plasticity changes in the central auditory system after the peripheral lesions were suggested to underlie this phenomenon, the neurological cause of exaggerated ASR is still not clear. In this study, the local field potentials and firing rates of the caudal pontine reticular nucleus (PnC), which plays a major role in the ASR pathway, were recorded in 2-month- and 6-month-old C57BL/6 J mice. Consistent with our previous studies, the amplitude of ASR increased, and the threshold of ASR decreased in the 6-month-old mice after developing 20–40 dB hearing loss. The PnC response induced by high-frequency stimuli (>20 kHz) decreased in the 6-month group, whereas the PnC response induced by low-frequency stimuli (<12 kHz) showed a significant increase in the 6-month group compared to the 2-month group. The enhancement of PnC response is similar to the ASR increase found in the 6-month-old C57 mice. Our results suggest that the high-frequency hearing loss caused an increase in PnC sensitivity in the C57 mice which may enhance ASRs.http://dx.doi.org/10.1155/2018/8169847 |
| spellingShingle | Ning Zhao Ana’am Alkharabsheh Fei Xu Wei Sun Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing Loss Neural Plasticity |
| title | Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing Loss |
| title_full | Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing Loss |
| title_fullStr | Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing Loss |
| title_full_unstemmed | Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing Loss |
| title_short | Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing Loss |
| title_sort | functional change in the caudal pontine reticular nucleus induced by age related hearing loss |
| url | http://dx.doi.org/10.1155/2018/8169847 |
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