Impact of health index and hospitals on dissemination of antibiotic resistance in two sewersheds of the third largest metropolitan region of Brazil
Antimicrobial resistance (AMR) stands as a critical threat to global public health. Wastewater-based epidemiology (WBE) provides health data within communities via sewage analysis. This study delved into antibiotic resistance prevalence across two sewersheds in Belo Horizonte, each with distinct hea...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Cleaner Water |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S295026322400019X |
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| author | Henrique Alves Santos Ana Paula Assad de Carvalho Juliana Calábria de Araújo |
| author_facet | Henrique Alves Santos Ana Paula Assad de Carvalho Juliana Calábria de Araújo |
| author_sort | Henrique Alves Santos |
| collection | DOAJ |
| description | Antimicrobial resistance (AMR) stands as a critical threat to global public health. Wastewater-based epidemiology (WBE) provides health data within communities via sewage analysis. This study delved into antibiotic resistance prevalence across two sewersheds in Belo Horizonte, each with distinct health vulnerability indexes (HVI) and number of hospitals. Bacteria resistant (ARB) to amoxicillin, azithromycin, cephalexin, sulfamethoxazole + trimethoprim, meropenem and ARGs (Intl1, sul1, blaTEM, blaKPC) were quantified in sewage from the two sewersheds over the years from 2020 to 2023. Statistical analysis revealed no significant differences in median concentrations of ARBs between sewersheds, except for bacteria resistant to meropenem. ARGs Investigated exhibited similar patterns, with blaKPC showing statistical significant difference. This suggests that hospital density within a sewershed exerts a more pronounced influence on AMR dissemination than HVI. The difference found in meropenem-resistant bacteria, a hospital-prescribed carbapenem, and blaKPC concentrations underscores the impact of hospital antibiotic usage. Thus, the presence and number of hospitals emerges as a pivotal factor in AMR spread, emphasizing the need for specific treatment and management of hospital wastewater to curb antimicrobial resistance. |
| format | Article |
| id | doaj-art-aaa392254fff4d339b162418d4dd4a41 |
| institution | OA Journals |
| issn | 2950-2632 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cleaner Water |
| spelling | doaj-art-aaa392254fff4d339b162418d4dd4a412025-08-20T01:57:55ZengElsevierCleaner Water2950-26322024-12-01210002110.1016/j.clwat.2024.100021Impact of health index and hospitals on dissemination of antibiotic resistance in two sewersheds of the third largest metropolitan region of BrazilHenrique Alves Santos0Ana Paula Assad de Carvalho1Juliana Calábria de Araújo2Federal University of Minas Gerais, Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais 31270-901, BrazilFederal University of Minas Gerais, Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais 31270-901, BrazilCorresponding author.; Federal University of Minas Gerais, Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais 31270-901, BrazilAntimicrobial resistance (AMR) stands as a critical threat to global public health. Wastewater-based epidemiology (WBE) provides health data within communities via sewage analysis. This study delved into antibiotic resistance prevalence across two sewersheds in Belo Horizonte, each with distinct health vulnerability indexes (HVI) and number of hospitals. Bacteria resistant (ARB) to amoxicillin, azithromycin, cephalexin, sulfamethoxazole + trimethoprim, meropenem and ARGs (Intl1, sul1, blaTEM, blaKPC) were quantified in sewage from the two sewersheds over the years from 2020 to 2023. Statistical analysis revealed no significant differences in median concentrations of ARBs between sewersheds, except for bacteria resistant to meropenem. ARGs Investigated exhibited similar patterns, with blaKPC showing statistical significant difference. This suggests that hospital density within a sewershed exerts a more pronounced influence on AMR dissemination than HVI. The difference found in meropenem-resistant bacteria, a hospital-prescribed carbapenem, and blaKPC concentrations underscores the impact of hospital antibiotic usage. Thus, the presence and number of hospitals emerges as a pivotal factor in AMR spread, emphasizing the need for specific treatment and management of hospital wastewater to curb antimicrobial resistance.http://www.sciencedirect.com/science/article/pii/S295026322400019XAntibiotic resistanceWastewater-based epidemiologyAntibiotic resistant bacteriaAntibiotic resistance genesAMR propagationDomestic and hospital sewage |
| spellingShingle | Henrique Alves Santos Ana Paula Assad de Carvalho Juliana Calábria de Araújo Impact of health index and hospitals on dissemination of antibiotic resistance in two sewersheds of the third largest metropolitan region of Brazil Cleaner Water Antibiotic resistance Wastewater-based epidemiology Antibiotic resistant bacteria Antibiotic resistance genes AMR propagation Domestic and hospital sewage |
| title | Impact of health index and hospitals on dissemination of antibiotic resistance in two sewersheds of the third largest metropolitan region of Brazil |
| title_full | Impact of health index and hospitals on dissemination of antibiotic resistance in two sewersheds of the third largest metropolitan region of Brazil |
| title_fullStr | Impact of health index and hospitals on dissemination of antibiotic resistance in two sewersheds of the third largest metropolitan region of Brazil |
| title_full_unstemmed | Impact of health index and hospitals on dissemination of antibiotic resistance in two sewersheds of the third largest metropolitan region of Brazil |
| title_short | Impact of health index and hospitals on dissemination of antibiotic resistance in two sewersheds of the third largest metropolitan region of Brazil |
| title_sort | impact of health index and hospitals on dissemination of antibiotic resistance in two sewersheds of the third largest metropolitan region of brazil |
| topic | Antibiotic resistance Wastewater-based epidemiology Antibiotic resistant bacteria Antibiotic resistance genes AMR propagation Domestic and hospital sewage |
| url | http://www.sciencedirect.com/science/article/pii/S295026322400019X |
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