EFFECT OF DICLOFENAС SODIUM ON MECHANISMS OF DIFFERENTIATION OF BONE MARROW CELLS AND PERIPHERAL BLOOD: A LITERATURE REVIEW
The hematopoietic system is a population of many cells that perform certain functions in the body. The pharmaceutical industry creates new drugs from the group of nonsteroidal anti-inflammatory drugs, but the “gold” standard remains the drug Diclofenac Sodium. In some conditions, a person is forced...
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| Format: | Article |
| Language: | English |
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Poltava State Medical University
2018-12-01
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| Series: | Проблеми екології та медицини |
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| Online Access: | https://ecomed-journal.org/index.php/journal/article/view/141 |
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| author | Yu. Bahmut O. S. Ivanov G. V. Tsapko |
| author_facet | Yu. Bahmut O. S. Ivanov G. V. Tsapko |
| author_sort | Yu. Bahmut |
| collection | DOAJ |
| description | The hematopoietic system is a population of many cells that perform certain functions in the body. The pharmaceutical industry creates new drugs from the group of nonsteroidal anti-inflammatory drugs, but the “gold” standard remains the drug Diclofenac Sodium. In some conditions, a person is forced to take the drug for a long time, and sometimes all life. The mechanism of the drug effect on the bone marrow cells under the condition of long-term administration remains unclear. In the process of analyzing the literature, it has been established that the use of the drug has a toxic effect on the blood cells and blood-forming organs. Gradually, the toxic effect is reduced, but the long-term effect of the drug on the rat organism contributes to the inhibition of the development of erythrocyte and myelocytic sprouts of the bone marrow. A period of up to 10 days is optimal for use, and then it is worthwhile to look for a drug that is safer for the body. |
| format | Article |
| id | doaj-art-aa93d60db2a6438488902346393d5443 |
| institution | Kabale University |
| issn | 2073-4662 2519-2302 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Poltava State Medical University |
| record_format | Article |
| series | Проблеми екології та медицини |
| spelling | doaj-art-aa93d60db2a6438488902346393d54432025-02-03T06:10:12ZengPoltava State Medical UniversityПроблеми екології та медицини2073-46622519-23022018-12-01225-6222410.31718/mep.2018.22.5-6.05141EFFECT OF DICLOFENAС SODIUM ON MECHANISMS OF DIFFERENTIATION OF BONE MARROW CELLS AND PERIPHERAL BLOOD: A LITERATURE REVIEWYu. Bahmut0O. S. Ivanov1G. V. Tsapko2Kharkiv Medical Academy of Postgraduate Education, KharkivKharkiv Medical Academy of Postgraduate Education, KharkivKharkiv Medical Academy of Postgraduate Education, KharkivThe hematopoietic system is a population of many cells that perform certain functions in the body. The pharmaceutical industry creates new drugs from the group of nonsteroidal anti-inflammatory drugs, but the “gold” standard remains the drug Diclofenac Sodium. In some conditions, a person is forced to take the drug for a long time, and sometimes all life. The mechanism of the drug effect on the bone marrow cells under the condition of long-term administration remains unclear. In the process of analyzing the literature, it has been established that the use of the drug has a toxic effect on the blood cells and blood-forming organs. Gradually, the toxic effect is reduced, but the long-term effect of the drug on the rat organism contributes to the inhibition of the development of erythrocyte and myelocytic sprouts of the bone marrow. A period of up to 10 days is optimal for use, and then it is worthwhile to look for a drug that is safer for the body.https://ecomed-journal.org/index.php/journal/article/view/141bone marrow, diclofenac sodium, erythrocytes, myelocytes, toxic effect |
| spellingShingle | Yu. Bahmut O. S. Ivanov G. V. Tsapko EFFECT OF DICLOFENAС SODIUM ON MECHANISMS OF DIFFERENTIATION OF BONE MARROW CELLS AND PERIPHERAL BLOOD: A LITERATURE REVIEW Проблеми екології та медицини bone marrow, diclofenac sodium, erythrocytes, myelocytes, toxic effect |
| title | EFFECT OF DICLOFENAС SODIUM ON MECHANISMS OF DIFFERENTIATION OF BONE MARROW CELLS AND PERIPHERAL BLOOD: A LITERATURE REVIEW |
| title_full | EFFECT OF DICLOFENAС SODIUM ON MECHANISMS OF DIFFERENTIATION OF BONE MARROW CELLS AND PERIPHERAL BLOOD: A LITERATURE REVIEW |
| title_fullStr | EFFECT OF DICLOFENAС SODIUM ON MECHANISMS OF DIFFERENTIATION OF BONE MARROW CELLS AND PERIPHERAL BLOOD: A LITERATURE REVIEW |
| title_full_unstemmed | EFFECT OF DICLOFENAС SODIUM ON MECHANISMS OF DIFFERENTIATION OF BONE MARROW CELLS AND PERIPHERAL BLOOD: A LITERATURE REVIEW |
| title_short | EFFECT OF DICLOFENAС SODIUM ON MECHANISMS OF DIFFERENTIATION OF BONE MARROW CELLS AND PERIPHERAL BLOOD: A LITERATURE REVIEW |
| title_sort | effect of diclofenaс sodium on mechanisms of differentiation of bone marrow cells and peripheral blood a literature review |
| topic | bone marrow, diclofenac sodium, erythrocytes, myelocytes, toxic effect |
| url | https://ecomed-journal.org/index.php/journal/article/view/141 |
| work_keys_str_mv | AT yubahmut effectofdiclofenassodiumonmechanismsofdifferentiationofbonemarrowcellsandperipheralbloodaliteraturereview AT osivanov effectofdiclofenassodiumonmechanismsofdifferentiationofbonemarrowcellsandperipheralbloodaliteraturereview AT gvtsapko effectofdiclofenassodiumonmechanismsofdifferentiationofbonemarrowcellsandperipheralbloodaliteraturereview |