Retrospective Evaluation of the Outcomes of Splenectomy in Patients with β-Thalassemia: Insights from a Tertiary Care Center in Bahawalpur
Objective: To evaluate outcomes of splenectomy in patients with β-thalassemia major. Study Design: A retrospective study. Place and Duration of Study: The study was conducted at the Department of Hematology, Bahawal Victoria Hospital Bahawalpur, Pakistan, from June 2022 to June 2023. Methods: A tot...
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| Format: | Article |
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National University of Medical Sciences
2025-01-01
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| Series: | Life and Science |
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| Online Access: | https://ojs.lifenscience.org/index.php/life-and-science/article/view/555 |
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| author | Muhammad Irfan khan Faseeh Abid Hafsa Malik Nadeem Shahid Younas Ayesha Sarfaraz Nausherwan Malik Haris Irfan Khan |
| author_facet | Muhammad Irfan khan Faseeh Abid Hafsa Malik Nadeem Shahid Younas Ayesha Sarfaraz Nausherwan Malik Haris Irfan Khan |
| author_sort | Muhammad Irfan khan |
| collection | DOAJ |
| description | Objective: To evaluate outcomes of splenectomy in patients with β-thalassemia major.
Study Design: A retrospective study.
Place and Duration of Study: The study was conducted at the Department of Hematology, Bahawal Victoria Hospital Bahawalpur, Pakistan, from June 2022 to June 2023.
Methods: A total of 80 patients with β-thalassemia were included. Participants were divided into Group A (n=40), including patients who had undergone splenectomy, and Group B (n=40), including patients with no splenectomy. The medical records of all participants were reviewed. Complete blood count, serum ferritin, and liver function tests were recorded. Flow cytometry was used to assess lymphocyte populations. Patients in Group A were evaluated 2 years after the splenectomy.
Results: Mean platelet and white blood cell count after splenectomy were 645.700/mm3 and 16.480/mm3 respectively. Splenectomy resulted in a significant increase in RBC indices, hematocrit, RBC count, and mean hemoglobin level. However, splenectomy did not decrease iron burden, and more patients required iron chelation. Group B had significantly higher total and indirect bilirubin compared to Group A. Splenectomy resulted in a significant increase in total and B lymphocytes. However, Group A had lower IgM Memory B lymphocytes than Group B. CD4 helper T lymphocytes, in total T lymphocytes, CD4+/CD8+ ratio and CD8 cytotoxic T lymphocytes did not differ significantly between both groups.
Conclusion: Splenectomy is associated with the risk of thrombocytosis in the long term. It improves anemia but does not impact blood transfusion requirement or iron burden. Preoperative vaccination can reduce the risk of overwhelming post splenectomy infections.
How to cite this: Khan MI, Abid F, Malik H, Younas NS, Sarfaraz A, Malik N, Khan HI. Retrospective Evaluation of the Outcomes of Splenectomy in Patients with β-Thalassemia: Insights from a Tertiary Care Center in Bahawalpur. Life and Science. 2025; 6(1): 109-115. doi: http://doi.org/10.37185/LnS.1.1.555 |
| format | Article |
| id | doaj-art-aa90e1805e4440d88d2b20c7d06c4c9a |
| institution | OA Journals |
| issn | 2521-0475 2708-2970 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | National University of Medical Sciences |
| record_format | Article |
| series | Life and Science |
| spelling | doaj-art-aa90e1805e4440d88d2b20c7d06c4c9a2025-08-20T01:50:06ZengNational University of Medical SciencesLife and Science2521-04752708-29702025-01-0161070710.37185/LnS.1.1.555555Retrospective Evaluation of the Outcomes of Splenectomy in Patients with β-Thalassemia: Insights from a Tertiary Care Center in BahawalpurMuhammad Irfan khan0Faseeh Abid1Hafsa Malik2Nadeem Shahid Younas3Ayesha Sarfaraz4Nausherwan Malik5Haris Irfan Khan6Shahida Islam Medical Complex Lodhran, PakistanBahawal Victoria Hospital (BVH) Bahawalpur, PakistanQuaid-e-Azam Medical College (QAMC) Bahawalpur, PakistanBahawal Victoria Hospital (BVH) Bahawalpur, PakistanBahawal Victoria Hospital (BVH) Bahawalpur, PakistanBahawal Victoria Hospital (BVH) Bahawalpur, PakistanBahawal Victoria Hospital (BVH) Bahawalpur, PakistanObjective: To evaluate outcomes of splenectomy in patients with β-thalassemia major. Study Design: A retrospective study. Place and Duration of Study: The study was conducted at the Department of Hematology, Bahawal Victoria Hospital Bahawalpur, Pakistan, from June 2022 to June 2023. Methods: A total of 80 patients with β-thalassemia were included. Participants were divided into Group A (n=40), including patients who had undergone splenectomy, and Group B (n=40), including patients with no splenectomy. The medical records of all participants were reviewed. Complete blood count, serum ferritin, and liver function tests were recorded. Flow cytometry was used to assess lymphocyte populations. Patients in Group A were evaluated 2 years after the splenectomy. Results: Mean platelet and white blood cell count after splenectomy were 645.700/mm3 and 16.480/mm3 respectively. Splenectomy resulted in a significant increase in RBC indices, hematocrit, RBC count, and mean hemoglobin level. However, splenectomy did not decrease iron burden, and more patients required iron chelation. Group B had significantly higher total and indirect bilirubin compared to Group A. Splenectomy resulted in a significant increase in total and B lymphocytes. However, Group A had lower IgM Memory B lymphocytes than Group B. CD4 helper T lymphocytes, in total T lymphocytes, CD4+/CD8+ ratio and CD8 cytotoxic T lymphocytes did not differ significantly between both groups. Conclusion: Splenectomy is associated with the risk of thrombocytosis in the long term. It improves anemia but does not impact blood transfusion requirement or iron burden. Preoperative vaccination can reduce the risk of overwhelming post splenectomy infections. How to cite this: Khan MI, Abid F, Malik H, Younas NS, Sarfaraz A, Malik N, Khan HI. Retrospective Evaluation of the Outcomes of Splenectomy in Patients with β-Thalassemia: Insights from a Tertiary Care Center in Bahawalpur. Life and Science. 2025; 6(1): 109-115. doi: http://doi.org/10.37185/LnS.1.1.555https://ojs.lifenscience.org/index.php/life-and-science/article/view/555blood transfusionred blood cellssplenomegalysplenectomy |
| spellingShingle | Muhammad Irfan khan Faseeh Abid Hafsa Malik Nadeem Shahid Younas Ayesha Sarfaraz Nausherwan Malik Haris Irfan Khan Retrospective Evaluation of the Outcomes of Splenectomy in Patients with β-Thalassemia: Insights from a Tertiary Care Center in Bahawalpur Life and Science blood transfusion red blood cells splenomegaly splenectomy |
| title | Retrospective Evaluation of the Outcomes of Splenectomy in Patients with β-Thalassemia: Insights from a Tertiary Care Center in Bahawalpur |
| title_full | Retrospective Evaluation of the Outcomes of Splenectomy in Patients with β-Thalassemia: Insights from a Tertiary Care Center in Bahawalpur |
| title_fullStr | Retrospective Evaluation of the Outcomes of Splenectomy in Patients with β-Thalassemia: Insights from a Tertiary Care Center in Bahawalpur |
| title_full_unstemmed | Retrospective Evaluation of the Outcomes of Splenectomy in Patients with β-Thalassemia: Insights from a Tertiary Care Center in Bahawalpur |
| title_short | Retrospective Evaluation of the Outcomes of Splenectomy in Patients with β-Thalassemia: Insights from a Tertiary Care Center in Bahawalpur |
| title_sort | retrospective evaluation of the outcomes of splenectomy in patients with β thalassemia insights from a tertiary care center in bahawalpur |
| topic | blood transfusion red blood cells splenomegaly splenectomy |
| url | https://ojs.lifenscience.org/index.php/life-and-science/article/view/555 |
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