Management of Locally Advanced Esthesioneuroblastoma in a Pregnant Woman
Esthesioneuroblastoma (ENB) is a rare malignant tumor that commonly develops in the upper nasal cavity. Standard treatment is not established, especially in locally advanced disease which portends the worse prognosis. Hereby, we report a case of a 27-year-old, 23-week pregnant woman, with a 2-month...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/3789317 |
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| author | Inês Maria Guerreiro Cláudia Vieira André Soares António Braga Manuel Jácome José Dinis |
| author_facet | Inês Maria Guerreiro Cláudia Vieira André Soares António Braga Manuel Jácome José Dinis |
| author_sort | Inês Maria Guerreiro |
| collection | DOAJ |
| description | Esthesioneuroblastoma (ENB) is a rare malignant tumor that commonly develops in the upper nasal cavity. Standard treatment is not established, especially in locally advanced disease which portends the worse prognosis. Hereby, we report a case of a 27-year-old, 23-week pregnant woman, with a 2-month history of progressively growing right cervical lymphadenopathy, nasal obstruction, anosmia, frequent episodes of epistaxis, and right frontal headache. Imagiological evaluation revealed a lesion with 7×5,2×3,2 cm in the nasal fossae with extension to the ethmoidal complex and right olfactive fend and invasion of the endocranial compartment associated with lymphadenopathy. The biopsy revealed a high-grade EBN. Neoadjuvant chemotherapy with cisplatin and etoposide was administrated during pregnancy and continued after delivery up to 6 cycles of treatment with partial response. Radiotherapy followed, with complete response. This case report is intended to highlight that a high grade of suspicion should be kept in the presence of nonspecific symptoms of nasal obstruction, anosmia, facial pain, and/or headache and focus that chemotherapy is an important component of a combined-treatment modality for locally advanced ENB that can be used during pregnancy in a lifesaving situation. |
| format | Article |
| id | doaj-art-aa8d484a2b254274a712f208d97db26e |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-aa8d484a2b254274a712f208d97db26e2025-08-20T03:39:35ZengWileyCase Reports in Oncological Medicine2090-67062090-67142019-01-01201910.1155/2019/37893173789317Management of Locally Advanced Esthesioneuroblastoma in a Pregnant WomanInês Maria Guerreiro0Cláudia Vieira1André Soares2António Braga3Manuel Jácome4José Dinis5Medical Oncology Department, Instituto Português de Oncologia do Porto Francisco Gentil (IPO-PORTO), Porto, PortugalMedical Oncology Department, Instituto Português de Oncologia do Porto Francisco Gentil (IPO-PORTO), Porto, PortugalRadiation Oncology Department, Instituto Português de Oncologia do Porto Francisco Gentil (IPO-PORTO), Porto, PortugalDepartment of Obstetrics and Gynecology, Centro Hospitalar do Porto, Porto, PortugalPathology Department, Instituto Português de Oncologia do Porto Francisco Gentil (IPO-PORTO), Porto, PortugalMedical Oncology Department, Instituto Português de Oncologia do Porto Francisco Gentil (IPO-PORTO), Porto, PortugalEsthesioneuroblastoma (ENB) is a rare malignant tumor that commonly develops in the upper nasal cavity. Standard treatment is not established, especially in locally advanced disease which portends the worse prognosis. Hereby, we report a case of a 27-year-old, 23-week pregnant woman, with a 2-month history of progressively growing right cervical lymphadenopathy, nasal obstruction, anosmia, frequent episodes of epistaxis, and right frontal headache. Imagiological evaluation revealed a lesion with 7×5,2×3,2 cm in the nasal fossae with extension to the ethmoidal complex and right olfactive fend and invasion of the endocranial compartment associated with lymphadenopathy. The biopsy revealed a high-grade EBN. Neoadjuvant chemotherapy with cisplatin and etoposide was administrated during pregnancy and continued after delivery up to 6 cycles of treatment with partial response. Radiotherapy followed, with complete response. This case report is intended to highlight that a high grade of suspicion should be kept in the presence of nonspecific symptoms of nasal obstruction, anosmia, facial pain, and/or headache and focus that chemotherapy is an important component of a combined-treatment modality for locally advanced ENB that can be used during pregnancy in a lifesaving situation.http://dx.doi.org/10.1155/2019/3789317 |
| spellingShingle | Inês Maria Guerreiro Cláudia Vieira André Soares António Braga Manuel Jácome José Dinis Management of Locally Advanced Esthesioneuroblastoma in a Pregnant Woman Case Reports in Oncological Medicine |
| title | Management of Locally Advanced Esthesioneuroblastoma in a Pregnant Woman |
| title_full | Management of Locally Advanced Esthesioneuroblastoma in a Pregnant Woman |
| title_fullStr | Management of Locally Advanced Esthesioneuroblastoma in a Pregnant Woman |
| title_full_unstemmed | Management of Locally Advanced Esthesioneuroblastoma in a Pregnant Woman |
| title_short | Management of Locally Advanced Esthesioneuroblastoma in a Pregnant Woman |
| title_sort | management of locally advanced esthesioneuroblastoma in a pregnant woman |
| url | http://dx.doi.org/10.1155/2019/3789317 |
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