Magnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration
Nowadays, tendon injuries represent a global health issue that annually affects millions of individuals. An innovative approach for their treatment is represented by the development of tissue engineered scaffolds able to support the host cells adhesion, differentiation, and proliferation. However, t...
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Elsevier
2025-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425002583 |
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| author | Eleonora Bianchi Manuel Bañobre-Lopez Marco Ruggeri Elena Del Favero Barbara Vigani Caterina Ricci Cinzia Boselli Antonia Icaro Cornaglia Martin Albino Claudio Sangregorio Alessandro Lascialfari Jessica Zanovello Eugenio Jannelli Francesco Claudio Pavesi Silvia Rossi Luca Casettari Giuseppina Sandri |
| author_facet | Eleonora Bianchi Manuel Bañobre-Lopez Marco Ruggeri Elena Del Favero Barbara Vigani Caterina Ricci Cinzia Boselli Antonia Icaro Cornaglia Martin Albino Claudio Sangregorio Alessandro Lascialfari Jessica Zanovello Eugenio Jannelli Francesco Claudio Pavesi Silvia Rossi Luca Casettari Giuseppina Sandri |
| author_sort | Eleonora Bianchi |
| collection | DOAJ |
| description | Nowadays, tendon injuries represent a global health issue that annually affects millions of individuals. An innovative approach for their treatment is represented by the development of tissue engineered scaffolds able to support the host cells adhesion, differentiation, and proliferation. However, the scaffold alone could be insufficient to guarantee an improvement of healing control. Magnetite nanoparticles (Fe3O4 NPs) are gaining interest due to their unique properties. In particular, when combined with bio-mimetic scaffolds, they should lead to the cells mechano-stimulation, improving the tenogenic differentiation and allowing a deeper tissue reparation.The aim of this work is the study and the development of scaffolds based on polyhydroxybutyrate and gelatin and doped with Fe3O4 NPs. The scaffolds are characterized by an aligned fibrous shape able to mimic the tendon fascicles. Moreover, they possess a superparamagnetic behavior and a slow degradation rate that should guarantee structural support during the tissue regeneration. The magnetic scaffolds promote cell proliferation and alignment onto the matrix, in particular when combined with the application of an external magnetic field. Also, the cells are able to differentiate and produce collagen I extracellular matrix. Finally, the magnetic scaffold in vivo promotes complete tissue healing after 1 week of treatment when combined with the external magnetic stimulation. |
| format | Article |
| id | doaj-art-aa8bbc67489d4b11a8a771676e7b22ad |
| institution | DOAJ |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-aa8bbc67489d4b11a8a771676e7b22ad2025-08-20T03:07:20ZengElsevierMaterials Today Bio2590-00642025-06-013210169910.1016/j.mtbio.2025.101699Magnetic scaffolds for the mechanotransduction stimulation in tendon tissue regenerationEleonora Bianchi0Manuel Bañobre-Lopez1Marco Ruggeri2Elena Del Favero3Barbara Vigani4Caterina Ricci5Cinzia Boselli6Antonia Icaro Cornaglia7Martin Albino8Claudio Sangregorio9Alessandro Lascialfari10Jessica Zanovello11Eugenio Jannelli12Francesco Claudio Pavesi13Silvia Rossi14Luca Casettari15Giuseppina Sandri16Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, ItalyInternational Iberian Nanotechnology Laboratory-INL, Braga, PortugalDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, ItalyDepartment of Medical Biotechnology and Translational Medicine, University of Milan, LITA Viale Fratelli Cervi 93, 20090, Segrate, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, ItalyDepartment of Medical Biotechnology and Translational Medicine, University of Milan, LITA Viale Fratelli Cervi 93, 20090, Segrate, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, ItalyDepartment of Public Health, Experimental and Forensic Medicine, University of Pavia, via Forlanini 2, 27100, Pavia, ItalyCNR-ICCOM, Sesto Fiorentino, Italy; Department of Chemistry “U. Schiff”, University of Florence and INSTM, I-50019, Sesto Fiorentino, FI, ItalyCNR-ICCOM, Sesto Fiorentino, Italy; Department of Chemistry “U. Schiff”, University of Florence and INSTM, I-50019, Sesto Fiorentino, FI, ItalyDepartment of Physics, University of Pavia and INFN section, Via Agostino Bassi 6, 27100, Pavia, ItalyOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100, Pavia, ItalyOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100, Pavia, ItalyOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100, Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, ItalyUniversità degli Studi di Urbino Carlo Bo, Urbino, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy; Corresponding author.Nowadays, tendon injuries represent a global health issue that annually affects millions of individuals. An innovative approach for their treatment is represented by the development of tissue engineered scaffolds able to support the host cells adhesion, differentiation, and proliferation. However, the scaffold alone could be insufficient to guarantee an improvement of healing control. Magnetite nanoparticles (Fe3O4 NPs) are gaining interest due to their unique properties. In particular, when combined with bio-mimetic scaffolds, they should lead to the cells mechano-stimulation, improving the tenogenic differentiation and allowing a deeper tissue reparation.The aim of this work is the study and the development of scaffolds based on polyhydroxybutyrate and gelatin and doped with Fe3O4 NPs. The scaffolds are characterized by an aligned fibrous shape able to mimic the tendon fascicles. Moreover, they possess a superparamagnetic behavior and a slow degradation rate that should guarantee structural support during the tissue regeneration. The magnetic scaffolds promote cell proliferation and alignment onto the matrix, in particular when combined with the application of an external magnetic field. Also, the cells are able to differentiate and produce collagen I extracellular matrix. Finally, the magnetic scaffold in vivo promotes complete tissue healing after 1 week of treatment when combined with the external magnetic stimulation.http://www.sciencedirect.com/science/article/pii/S2590006425002583Tendon disordersMagnetite nanoparticlesMechanotransductionPolyhydroxybutyrateGelatinMagnetic scaffolds |
| spellingShingle | Eleonora Bianchi Manuel Bañobre-Lopez Marco Ruggeri Elena Del Favero Barbara Vigani Caterina Ricci Cinzia Boselli Antonia Icaro Cornaglia Martin Albino Claudio Sangregorio Alessandro Lascialfari Jessica Zanovello Eugenio Jannelli Francesco Claudio Pavesi Silvia Rossi Luca Casettari Giuseppina Sandri Magnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration Materials Today Bio Tendon disorders Magnetite nanoparticles Mechanotransduction Polyhydroxybutyrate Gelatin Magnetic scaffolds |
| title | Magnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration |
| title_full | Magnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration |
| title_fullStr | Magnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration |
| title_full_unstemmed | Magnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration |
| title_short | Magnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration |
| title_sort | magnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration |
| topic | Tendon disorders Magnetite nanoparticles Mechanotransduction Polyhydroxybutyrate Gelatin Magnetic scaffolds |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425002583 |
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