DYNAMICS OF SYSTEMIC INFLAMMATORY RESPONSE MARKERS IN PATIENTS WITH URGENT CONDITIONS DEPEND-ING ON THE DEVELOPMENT OF SEPSIS
Background There is still no information on the dynamics of pro- and anti-inflammatory cytokines and mark-ers of the septic process before the clinical manifestation of sepsis. The aim of the study was to analyze the dynamics of inflammation and sepsis markers concentration in early periods in patie...
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| Language: | Russian |
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Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
2018-04-01
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| Series: | Неотложная медицинская помощь |
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| Online Access: | https://www.jnmp.ru/jour/article/view/432 |
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| author | G. V. Bulava A. K. Shabanov O. V. Nikitina E. V. Kislukhina |
| author_facet | G. V. Bulava A. K. Shabanov O. V. Nikitina E. V. Kislukhina |
| author_sort | G. V. Bulava |
| collection | DOAJ |
| description | Background There is still no information on the dynamics of pro- and anti-inflammatory cytokines and mark-ers of the septic process before the clinical manifestation of sepsis. The aim of the study was to analyze the dynamics of inflammation and sepsis markers concentration in early periods in patients with urgent pathology, depending on the subsequently developed sepsis. Materials and methods. The concentration of procalcitonin, C-reactive protein, LBP, IL-6, IL-10, IL-2R in 61 patients with a high risk of sepsis was investigated starting from the first day after admission to the hospital and then with intervals of 3–5 days. The Group 1 included 29 patients with verified sepsis. All patients of this group survived. The Group 2 included 8 patients who died. The Group 3 included 24 patients who had no clinical signs of sepsis. All the patients in this group recovered. Results. We revealed significant differences in concentrations of systemic inflammatory response markers and its dynamics in the period preceding clinical manifestations of sepsis. It was found that it was possible to predict the development of sepsis and its unfavorable outcome with a high statistical probability in the study of paired samples of blood serum of patients received on day 1–3 and 4–6 from the onset of the disease or severe trauma. The predictors were multidirectional changes of IL-6, IL-10, LBP concentrations and more than three-fold IL-2R increase on the background of high concentrations of procalcitonin and C-reactive protein. Conclusion. The highest concentrations of procalcitonin, C-reactive protein, IL-10 and IL-2R were revealed within the first three days in patients who died of sepsis. High concentrations of IL-6 and IL-10 within first three days and different directions of their concentrations during the next 4–6 days indicate the development of sepsis with an unfavorable outcome. Reduction of IL-2R and IL-6 and an increase in IL-10 within the first week after the onset of the disease or trau-ma are predictors of lethal outcome. |
| format | Article |
| id | doaj-art-aa870ca0b62a4e488ebdcbf9eb0a028f |
| institution | DOAJ |
| issn | 2223-9022 2541-8017 |
| language | Russian |
| publishDate | 2018-04-01 |
| publisher | Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department |
| record_format | Article |
| series | Неотложная медицинская помощь |
| spelling | doaj-art-aa870ca0b62a4e488ebdcbf9eb0a028f2025-08-20T03:18:31ZrusSklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare DepartmentНеотложная медицинская помощь2223-90222541-80172018-04-0171131910.23934/2223-9022-2018-7-1-13-19412DYNAMICS OF SYSTEMIC INFLAMMATORY RESPONSE MARKERS IN PATIENTS WITH URGENT CONDITIONS DEPEND-ING ON THE DEVELOPMENT OF SEPSISG. V. Bulava0A. K. Shabanov1O. V. Nikitina2E. V. Kislukhina3N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department, MoscowN.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department, MoscowN.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department, MoscowN.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department, MoscowBackground There is still no information on the dynamics of pro- and anti-inflammatory cytokines and mark-ers of the septic process before the clinical manifestation of sepsis. The aim of the study was to analyze the dynamics of inflammation and sepsis markers concentration in early periods in patients with urgent pathology, depending on the subsequently developed sepsis. Materials and methods. The concentration of procalcitonin, C-reactive protein, LBP, IL-6, IL-10, IL-2R in 61 patients with a high risk of sepsis was investigated starting from the first day after admission to the hospital and then with intervals of 3–5 days. The Group 1 included 29 patients with verified sepsis. All patients of this group survived. The Group 2 included 8 patients who died. The Group 3 included 24 patients who had no clinical signs of sepsis. All the patients in this group recovered. Results. We revealed significant differences in concentrations of systemic inflammatory response markers and its dynamics in the period preceding clinical manifestations of sepsis. It was found that it was possible to predict the development of sepsis and its unfavorable outcome with a high statistical probability in the study of paired samples of blood serum of patients received on day 1–3 and 4–6 from the onset of the disease or severe trauma. The predictors were multidirectional changes of IL-6, IL-10, LBP concentrations and more than three-fold IL-2R increase on the background of high concentrations of procalcitonin and C-reactive protein. Conclusion. The highest concentrations of procalcitonin, C-reactive protein, IL-10 and IL-2R were revealed within the first three days in patients who died of sepsis. High concentrations of IL-6 and IL-10 within first three days and different directions of their concentrations during the next 4–6 days indicate the development of sepsis with an unfavorable outcome. Reduction of IL-2R and IL-6 and an increase in IL-10 within the first week after the onset of the disease or trau-ma are predictors of lethal outcome.https://www.jnmp.ru/jour/article/view/432urgent conditionssystemic inflammatory responseearly predictors of sepsis and lethal outcome |
| spellingShingle | G. V. Bulava A. K. Shabanov O. V. Nikitina E. V. Kislukhina DYNAMICS OF SYSTEMIC INFLAMMATORY RESPONSE MARKERS IN PATIENTS WITH URGENT CONDITIONS DEPEND-ING ON THE DEVELOPMENT OF SEPSIS Неотложная медицинская помощь urgent conditions systemic inflammatory response early predictors of sepsis and lethal outcome |
| title | DYNAMICS OF SYSTEMIC INFLAMMATORY RESPONSE MARKERS IN PATIENTS WITH URGENT CONDITIONS DEPEND-ING ON THE DEVELOPMENT OF SEPSIS |
| title_full | DYNAMICS OF SYSTEMIC INFLAMMATORY RESPONSE MARKERS IN PATIENTS WITH URGENT CONDITIONS DEPEND-ING ON THE DEVELOPMENT OF SEPSIS |
| title_fullStr | DYNAMICS OF SYSTEMIC INFLAMMATORY RESPONSE MARKERS IN PATIENTS WITH URGENT CONDITIONS DEPEND-ING ON THE DEVELOPMENT OF SEPSIS |
| title_full_unstemmed | DYNAMICS OF SYSTEMIC INFLAMMATORY RESPONSE MARKERS IN PATIENTS WITH URGENT CONDITIONS DEPEND-ING ON THE DEVELOPMENT OF SEPSIS |
| title_short | DYNAMICS OF SYSTEMIC INFLAMMATORY RESPONSE MARKERS IN PATIENTS WITH URGENT CONDITIONS DEPEND-ING ON THE DEVELOPMENT OF SEPSIS |
| title_sort | dynamics of systemic inflammatory response markers in patients with urgent conditions depend ing on the development of sepsis |
| topic | urgent conditions systemic inflammatory response early predictors of sepsis and lethal outcome |
| url | https://www.jnmp.ru/jour/article/view/432 |
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