The effects of TGF-β receptor I inhibitors on myofibroblast differentiation and myotube formation

The effects of TGF-β receptor I inhibitors on myofibroblast differentiation and myotube formation

IntroductionFibrosis frequently occurs in muscle wounds, ultimately leading to suboptimal function. This study investigates the effects of TGF-βRI inhibitors AZ12799734, Galunisertib, and SM16, on myofibroblast differentiation and myotube formation.MethodsHuman gingival fibroblasts were treated with...

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Bibliographic Details
Main Authors: Zhihao Wang, Edwin. M. Ongkosuwito, Johannes W. Von den Hoff, Frank A. D. T. G. Wagener
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TGF-βRI inhibitors
myotube
myofibroblast
C2C12
fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1636884/full
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