Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Background. It has been found that single-nucleotide polymorphisms (SNPs) of microRNA might be involved in the development of inflammatory bowel diseases (IBDs). However, the related retrospective research has not been reported. In this work, we performed a meta-analysis to derive a more precise est...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/7295131 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849395569289592832 |
|---|---|
| author | Ying Liu Lingxin Xiong Yan Zhou Bingzhen Zheng Tongjun Liu Wei Xie |
| author_facet | Ying Liu Lingxin Xiong Yan Zhou Bingzhen Zheng Tongjun Liu Wei Xie |
| author_sort | Ying Liu |
| collection | DOAJ |
| description | Background. It has been found that single-nucleotide polymorphisms (SNPs) of microRNA might be involved in the development of inflammatory bowel diseases (IBDs). However, the related retrospective research has not been reported. In this work, we performed a meta-analysis to derive a more precise estimation of the associated relationship. Methods. We searched the studies on the association of SNPs of microRNA with the hereditary susceptibility of IBD in PubMed and Embase; eligible research was selected by screening the abstract and full text. The meta-analysis was performed based on the statistical software Stata 14.0, and besides, the odds ratio and 95% confidence interval were calculated to evaluate the strength of the association. Results. 159 papers were acquired from the PubMed and Embase databases, and five eligible articles containing nine case-control studies were selected. In the study, we first found that the association between miRNA-196a2 rs11614913 and IBD was insignificant. Then, the susceptibility of miRNA-146a rs2910146 to IBD increased significantly in allelic comparison, homozygote model, heterozygote model, and dominant model. Moreover, a positive relationship between miRNA-499 rs3746444 and IBD was identified in the homozygote model. Conclusion. Our findings demonstrated that miRNA-146a rs2910146 (G>C) polymorphism was associated with the susceptibility to IBD and miRNA-196a2 rs11614913 (T>C) and miRNA-499 rs3746444 (A>G) did not reveal an obvious relationship with the IBD susceptibility. |
| format | Article |
| id | doaj-art-aa8397a98cbc44a0bacb8d0b62fd89fd |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-aa8397a98cbc44a0bacb8d0b62fd89fd2025-08-20T03:39:33ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/72951317295131Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-AnalysisYing Liu0Lingxin Xiong1Yan Zhou2Bingzhen Zheng3Tongjun Liu4Wei Xie5Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, ChinaSchool of Pharmaceutical Sciences, Jilin University, Changchun, ChinaDepartment of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, ChinaSchool of Pharmaceutical Sciences, Jilin University, Changchun, ChinaDepartment of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, ChinaSchool of Business Administration, South China University of Technology, Guangzhou, ChinaBackground. It has been found that single-nucleotide polymorphisms (SNPs) of microRNA might be involved in the development of inflammatory bowel diseases (IBDs). However, the related retrospective research has not been reported. In this work, we performed a meta-analysis to derive a more precise estimation of the associated relationship. Methods. We searched the studies on the association of SNPs of microRNA with the hereditary susceptibility of IBD in PubMed and Embase; eligible research was selected by screening the abstract and full text. The meta-analysis was performed based on the statistical software Stata 14.0, and besides, the odds ratio and 95% confidence interval were calculated to evaluate the strength of the association. Results. 159 papers were acquired from the PubMed and Embase databases, and five eligible articles containing nine case-control studies were selected. In the study, we first found that the association between miRNA-196a2 rs11614913 and IBD was insignificant. Then, the susceptibility of miRNA-146a rs2910146 to IBD increased significantly in allelic comparison, homozygote model, heterozygote model, and dominant model. Moreover, a positive relationship between miRNA-499 rs3746444 and IBD was identified in the homozygote model. Conclusion. Our findings demonstrated that miRNA-146a rs2910146 (G>C) polymorphism was associated with the susceptibility to IBD and miRNA-196a2 rs11614913 (T>C) and miRNA-499 rs3746444 (A>G) did not reveal an obvious relationship with the IBD susceptibility.http://dx.doi.org/10.1155/2018/7295131 |
| spellingShingle | Ying Liu Lingxin Xiong Yan Zhou Bingzhen Zheng Tongjun Liu Wei Xie Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis Gastroenterology Research and Practice |
| title | Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis |
| title_full | Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis |
| title_fullStr | Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis |
| title_short | Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis |
| title_sort | association of three polymorphisms rs11614913 rs2910146 and rs3746444 in mirna 196a2 mirna 146a and mirna 499 with inflammatory bowel disease a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2018/7295131 |
| work_keys_str_mv | AT yingliu associationofthreepolymorphismsrs11614913rs2910146andrs3746444inmirna196a2mirna146aandmirna499withinflammatoryboweldiseaseasystematicreviewandmetaanalysis AT lingxinxiong associationofthreepolymorphismsrs11614913rs2910146andrs3746444inmirna196a2mirna146aandmirna499withinflammatoryboweldiseaseasystematicreviewandmetaanalysis AT yanzhou associationofthreepolymorphismsrs11614913rs2910146andrs3746444inmirna196a2mirna146aandmirna499withinflammatoryboweldiseaseasystematicreviewandmetaanalysis AT bingzhenzheng associationofthreepolymorphismsrs11614913rs2910146andrs3746444inmirna196a2mirna146aandmirna499withinflammatoryboweldiseaseasystematicreviewandmetaanalysis AT tongjunliu associationofthreepolymorphismsrs11614913rs2910146andrs3746444inmirna196a2mirna146aandmirna499withinflammatoryboweldiseaseasystematicreviewandmetaanalysis AT weixie associationofthreepolymorphismsrs11614913rs2910146andrs3746444inmirna196a2mirna146aandmirna499withinflammatoryboweldiseaseasystematicreviewandmetaanalysis |