Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients
Elevated resting heart rate (RHR) has been associated with increased risk of mortality and cardiovascular events. Limited data are available so far in type 2 diabetic (T2DM) subjects with no study focusing on progressive renal decline specifically. Aims of our study were to verify RHR as a simple an...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/6726492 |
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| author | Vendula Bartáková Linda Klimešová Katarína Kianičková Veronika Dvořáková Denisa Malúšková Jitka Řehořová Jan Svojanovský Jindřich Olšovský Jana Bělobrádková Kateřina Kaňková |
| author_facet | Vendula Bartáková Linda Klimešová Katarína Kianičková Veronika Dvořáková Denisa Malúšková Jitka Řehořová Jan Svojanovský Jindřich Olšovský Jana Bělobrádková Kateřina Kaňková |
| author_sort | Vendula Bartáková |
| collection | DOAJ |
| description | Elevated resting heart rate (RHR) has been associated with increased risk of mortality and cardiovascular events. Limited data are available so far in type 2 diabetic (T2DM) subjects with no study focusing on progressive renal decline specifically. Aims of our study were to verify RHR as a simple and reliable predictor of adverse disease outcomes in T2DM patients. A total of 421 T2DM patients with variable baseline stage of diabetic kidney disease (DKD) were prospectively followed. A history of the cardiovascular disease was present in 81 (19.2%) patients at baseline, and DKD (glomerular filtration rate < 60 mL/min or proteinuria) was present in 328 (77.9%) at baseline. Progressive renal decline was defined as a continuous rate of glomerular filtration rate loss ≥ 3.3% per year. Resting heart rate was not significantly higher in subjects with cardiovascular disease or DKD at baseline compared to those without. Using time-to-event analyses, significant differences in the cumulative incidence of the studied outcomes, that is, progression of DKD (and specifically progressive renal decline), major advanced cardiovascular event, and all-cause mortality, between RHR </≥65 (arbitrary cut-off) and 75 (median) bpm were not found. We did not ascertain predictive value of the RHR for the renal or cardiovascular outcomes in T2DM subjects in Czech Republic. |
| format | Article |
| id | doaj-art-aa80a7d10e1d46c3b864419347fb72e2 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-aa80a7d10e1d46c3b864419347fb72e22025-08-20T02:20:54ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/67264926726492Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic PatientsVendula Bartáková0Linda Klimešová1Katarína Kianičková2Veronika Dvořáková3Denisa Malúšková4Jitka Řehořová5Jan Svojanovský6Jindřich Olšovský7Jana Bělobrádková8Kateřina Kaňková9Department of Pathophysiology, Medical Faculty, Masaryk University Brno, Kamenice 5, 62500 Brno, Czech RepublicDepartment of Pathophysiology, Medical Faculty, Masaryk University Brno, Kamenice 5, 62500 Brno, Czech RepublicDepartment of Pathophysiology, Medical Faculty, Masaryk University Brno, Kamenice 5, 62500 Brno, Czech RepublicDepartment of Pathophysiology, Medical Faculty, Masaryk University Brno, Kamenice 5, 62500 Brno, Czech RepublicInstitute of Biostatistics and Analyses, Masaryk University Brno, Kamenice 126/3, 62500 Brno, Czech RepublicDepartment of Internal Medicine-Gastroenterology, University Hospital Brno, Jihlavská 20, 62500 Brno, Czech Republic2nd Department of Internal Medicine, St. Anne’s University Hospital, Pekařská 53, 65691 Brno, Czech Republic2nd Department of Internal Medicine, St. Anne’s University Hospital, Pekařská 53, 65691 Brno, Czech RepublicDepartment of Internal Medicine-Gastroenterology, University Hospital Brno, Jihlavská 20, 62500 Brno, Czech RepublicDepartment of Pathophysiology, Medical Faculty, Masaryk University Brno, Kamenice 5, 62500 Brno, Czech RepublicElevated resting heart rate (RHR) has been associated with increased risk of mortality and cardiovascular events. Limited data are available so far in type 2 diabetic (T2DM) subjects with no study focusing on progressive renal decline specifically. Aims of our study were to verify RHR as a simple and reliable predictor of adverse disease outcomes in T2DM patients. A total of 421 T2DM patients with variable baseline stage of diabetic kidney disease (DKD) were prospectively followed. A history of the cardiovascular disease was present in 81 (19.2%) patients at baseline, and DKD (glomerular filtration rate < 60 mL/min or proteinuria) was present in 328 (77.9%) at baseline. Progressive renal decline was defined as a continuous rate of glomerular filtration rate loss ≥ 3.3% per year. Resting heart rate was not significantly higher in subjects with cardiovascular disease or DKD at baseline compared to those without. Using time-to-event analyses, significant differences in the cumulative incidence of the studied outcomes, that is, progression of DKD (and specifically progressive renal decline), major advanced cardiovascular event, and all-cause mortality, between RHR </≥65 (arbitrary cut-off) and 75 (median) bpm were not found. We did not ascertain predictive value of the RHR for the renal or cardiovascular outcomes in T2DM subjects in Czech Republic.http://dx.doi.org/10.1155/2016/6726492 |
| spellingShingle | Vendula Bartáková Linda Klimešová Katarína Kianičková Veronika Dvořáková Denisa Malúšková Jitka Řehořová Jan Svojanovský Jindřich Olšovský Jana Bělobrádková Kateřina Kaňková Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients Journal of Diabetes Research |
| title | Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients |
| title_full | Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients |
| title_fullStr | Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients |
| title_full_unstemmed | Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients |
| title_short | Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients |
| title_sort | resting heart rate does not predict cardiovascular and renal outcomes in type 2 diabetic patients |
| url | http://dx.doi.org/10.1155/2016/6726492 |
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