Synthesis of Substituted 1,4-Benzodiazepines by Palladium-Catalyzed Cyclization of <i>N</i>-Tosyl-Disubstituted 2-Aminobenzylamines with Propargylic Carbonates

Synthesis of Substituted 1,4-Benzodiazepines by Palladium-Catalyzed Cyclization of <i>N</i>-Tosyl-Disubstituted 2-Aminobenzylamines with Propargylic Carbonates

A synthesis of substituted 1,4-benzodiazepines has been developed via palladium-catalyzed cyclization of <i>N</i>-tosyl-disubstituted 2-aminobenzylamines with propargylic carbonates. The reaction proceeds through the formation of π-allylpalladium intermediates, which undergo intramolecul...

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Bibliographic Details
Main Authors: Masahiro Yoshida, Saya Okubo, Akira Kurosaka, Shunya Mori, Touya Kariya, Kenji Matsumoto
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
1,4-benzodiazepine
cascade reaction
cyclization
palladium catalyst
propargylic carbonate
Online Access:https://www.mdpi.com/1420-3049/30/14/3004
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