Host-bacteria metabolic crosstalk drives S. aureus biofilm
Staphylococcus aureus is a prominent pathogen that can cause intractable lung infections in humans. S. aureus persists in the airway despite inflammation and immune cell recruitment by adapting to host-derived antimicrobial factors. A key component of the immune response to infection are host metabo...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2021-04-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/2021a-tomlinson-microbial-cell/ |
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| author | Kira L. Tomlinson Sebastián A. Riquelme |
| author_facet | Kira L. Tomlinson Sebastián A. Riquelme |
| author_sort | Kira L. Tomlinson |
| collection | DOAJ |
| description | Staphylococcus aureus is a prominent pathogen that can cause intractable lung infections in humans. S. aureus persists in the airway despite inflammation and immune cell recruitment by adapting to host-derived antimicrobial factors. A key component of the immune response to infection are host metabolites that regulate inflammation and bacterial survival. In our recent paper (Tomlinson et al., Nat Commun, doi: 10.1038/s41467-021-21718-y), we demonstrated that S. aureus induces the production of the immunoreglatory metabolite itaconate in airway immune cells by stimulating mitochondrial oxidant stress. Itaconate in turn inhibited S. aureus glycolysis and growth, and promoted carbon flux through bacterial metabolic pathways that support biofilm production. These itaconate-induced metabolic changes were recapitulated in a longitudinal series of clinical isolates from a patient with chronic staphylococcal lung infections, demonstrating a role for host immunometabolism in driving bacterial persistence during long-term staphylococcal lung infections. |
| format | Article |
| id | doaj-art-aa7631c97fdc41388fdfc4377a52f91f |
| institution | DOAJ |
| issn | 2311-2638 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-aa7631c97fdc41388fdfc4377a52f91f2025-08-20T02:53:21ZengShared Science Publishers OGMicrobial Cell2311-26382021-04-018510610710.15698/mic2021.05.749Host-bacteria metabolic crosstalk drives S. aureus biofilmKira L. Tomlinson0Sebastián A. Riquelme1Department of Pediatrics, Columbia University, New York, NY 10032, USA.Department of Pediatrics, Columbia University, New York, NY 10032, USA.Staphylococcus aureus is a prominent pathogen that can cause intractable lung infections in humans. S. aureus persists in the airway despite inflammation and immune cell recruitment by adapting to host-derived antimicrobial factors. A key component of the immune response to infection are host metabolites that regulate inflammation and bacterial survival. In our recent paper (Tomlinson et al., Nat Commun, doi: 10.1038/s41467-021-21718-y), we demonstrated that S. aureus induces the production of the immunoreglatory metabolite itaconate in airway immune cells by stimulating mitochondrial oxidant stress. Itaconate in turn inhibited S. aureus glycolysis and growth, and promoted carbon flux through bacterial metabolic pathways that support biofilm production. These itaconate-induced metabolic changes were recapitulated in a longitudinal series of clinical isolates from a patient with chronic staphylococcal lung infections, demonstrating a role for host immunometabolism in driving bacterial persistence during long-term staphylococcal lung infections.http://microbialcell.com/researcharticles/2021a-tomlinson-microbial-cell/staphylococcus aureusbiofilmpneumoniaitaconateimmunometabolism |
| spellingShingle | Kira L. Tomlinson Sebastián A. Riquelme Host-bacteria metabolic crosstalk drives S. aureus biofilm Microbial Cell staphylococcus aureus biofilm pneumonia itaconate immunometabolism |
| title | Host-bacteria metabolic crosstalk drives S. aureus biofilm |
| title_full | Host-bacteria metabolic crosstalk drives S. aureus biofilm |
| title_fullStr | Host-bacteria metabolic crosstalk drives S. aureus biofilm |
| title_full_unstemmed | Host-bacteria metabolic crosstalk drives S. aureus biofilm |
| title_short | Host-bacteria metabolic crosstalk drives S. aureus biofilm |
| title_sort | host bacteria metabolic crosstalk drives s aureus biofilm |
| topic | staphylococcus aureus biofilm pneumonia itaconate immunometabolism |
| url | http://microbialcell.com/researcharticles/2021a-tomlinson-microbial-cell/ |
| work_keys_str_mv | AT kiraltomlinson hostbacteriametaboliccrosstalkdrivessaureusbiofilm AT sebastianariquelme hostbacteriametaboliccrosstalkdrivessaureusbiofilm |