The Diabetic Heart: Too Sweet for Its Own Good?
Diabetes mellitus is a major risk factor for ischemic heart disease (IHD). Patients with diabetes and IHD experience worse clinical outcomes, suggesting that the diabetic heart may be more susceptible to ischemia-reperfusion injury (IRI). In contrast, the animal data suggests that the diabetic heart...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/845698 |
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| _version_ | 1849395552375013376 |
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| author | Hannah J. Whittington Girish G. Babu Mihaela M. Mocanu Derek M. Yellon Derek J. Hausenloy |
| author_facet | Hannah J. Whittington Girish G. Babu Mihaela M. Mocanu Derek M. Yellon Derek J. Hausenloy |
| author_sort | Hannah J. Whittington |
| collection | DOAJ |
| description | Diabetes mellitus is a major risk factor for ischemic heart disease (IHD). Patients with diabetes and IHD experience worse clinical outcomes, suggesting that the diabetic heart may be more susceptible to ischemia-reperfusion injury (IRI). In contrast, the animal data suggests that the diabetic heart may be either more, equally, or even less susceptible to IRI. The conflicting animal data may be due to the choice of diabetic and/or IRI animal model. Ischemic conditioning, a phenomenon in which the heart is protected against IRI by one or more brief nonlethal periods of ischemia and reperfusion, may provide a novel cardioprotective strategy for the diabetic heart. Whether the diabetic heart is amenable to ischemic conditioning remains to be determined using relevant animal models of IRI and/or diabetes. In this paper, we review the limitations of the current experimental models used to investigate IRI and cardioprotection in the diabetic heart. |
| format | Article |
| id | doaj-art-aa7568e1d65547ffb9eac51a45e9f84d |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-aa7568e1d65547ffb9eac51a45e9f84d2025-08-20T03:39:35ZengWileyCardiology Research and Practice2090-80162090-05972012-01-01201210.1155/2012/845698845698The Diabetic Heart: Too Sweet for Its Own Good?Hannah J. Whittington0Girish G. Babu1Mihaela M. Mocanu2Derek M. Yellon3Derek J. Hausenloy4The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UKThe Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UKThe Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UKThe Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UKThe Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UKDiabetes mellitus is a major risk factor for ischemic heart disease (IHD). Patients with diabetes and IHD experience worse clinical outcomes, suggesting that the diabetic heart may be more susceptible to ischemia-reperfusion injury (IRI). In contrast, the animal data suggests that the diabetic heart may be either more, equally, or even less susceptible to IRI. The conflicting animal data may be due to the choice of diabetic and/or IRI animal model. Ischemic conditioning, a phenomenon in which the heart is protected against IRI by one or more brief nonlethal periods of ischemia and reperfusion, may provide a novel cardioprotective strategy for the diabetic heart. Whether the diabetic heart is amenable to ischemic conditioning remains to be determined using relevant animal models of IRI and/or diabetes. In this paper, we review the limitations of the current experimental models used to investigate IRI and cardioprotection in the diabetic heart.http://dx.doi.org/10.1155/2012/845698 |
| spellingShingle | Hannah J. Whittington Girish G. Babu Mihaela M. Mocanu Derek M. Yellon Derek J. Hausenloy The Diabetic Heart: Too Sweet for Its Own Good? Cardiology Research and Practice |
| title | The Diabetic Heart: Too Sweet for Its Own Good? |
| title_full | The Diabetic Heart: Too Sweet for Its Own Good? |
| title_fullStr | The Diabetic Heart: Too Sweet for Its Own Good? |
| title_full_unstemmed | The Diabetic Heart: Too Sweet for Its Own Good? |
| title_short | The Diabetic Heart: Too Sweet for Its Own Good? |
| title_sort | diabetic heart too sweet for its own good |
| url | http://dx.doi.org/10.1155/2012/845698 |
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