Green synthesis of Ag/Fe3O4 nanoparticles using Mentha extract: Preparation, characterization and investigation of its anti-human lung cancer application
In this study, silver nanoparticles (Ag NPs) were decorated on the surface of magnetic nanoparticles in an eco-friendly pathway applying Mentha extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepared Ag/Fe3O4nanocomposite were determined using several ad...
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| Format: | Article |
| Language: | English |
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Springer
2022-07-01
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| Series: | Journal of Saudi Chemical Society |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610322000874 |
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| author | Tao Huang Huda S. AlSalem Mona Saad Binkadem Soha Talal Al-Goul Attalla F. El-kott Abdulrahman A. Alsayegh Ghawi J. Majdou Gaber El-Saber Batiha Bikash Karmakar |
| author_facet | Tao Huang Huda S. AlSalem Mona Saad Binkadem Soha Talal Al-Goul Attalla F. El-kott Abdulrahman A. Alsayegh Ghawi J. Majdou Gaber El-Saber Batiha Bikash Karmakar |
| author_sort | Tao Huang |
| collection | DOAJ |
| description | In this study, silver nanoparticles (Ag NPs) were decorated on the surface of magnetic nanoparticles in an eco-friendly pathway applying Mentha extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepared Ag/Fe3O4nanocomposite were determined using several advanced techniques. Hence, our protocol is green and advantageous in terms of- i) biochemical modified biocompatible nanocomposite; ii) nanomaterial providing high surface area and larger number reactive sites; iii) very simplistic synthetic procedure; vi) very low load of metal in the composite and v) high yield in short time. In the medicinal part, the anticancer properties of Ag/Fe3O4 nanocomposite against lung cancer cell lines were determined. The free radical for the antioxidant effects was DPPH. The IC50 of Ag/Fe3O4 nanocomposite was 200 µg/ml in the antioxidant test. The IC50 of the Ag/Fe3O4 nanocomposite were 183, 176, 169, and 125 µg/mL against lung cancer (NCI-H661, NCI-H1975, NCI-H1573, and NCI-H1563) cell lines, respectively. In addition, the current study offer that Ag/Fe3O4 nanocomposite could be a new potential adjuvant chemopreventive and chemotherapeutic agent against cytotoxic cells. |
| format | Article |
| id | doaj-art-aa75415ce2974dbfb27f774d32d15d2e |
| institution | Kabale University |
| issn | 1319-6103 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj-art-aa75415ce2974dbfb27f774d32d15d2e2025-08-20T03:48:32ZengSpringerJournal of Saudi Chemical Society1319-61032022-07-0126410150510.1016/j.jscs.2022.101505Green synthesis of Ag/Fe3O4 nanoparticles using Mentha extract: Preparation, characterization and investigation of its anti-human lung cancer applicationTao Huang0Huda S. AlSalem1Mona Saad Binkadem2Soha Talal Al-Goul3Attalla F. El-kott4Abdulrahman A. Alsayegh5Ghawi J. Majdou6Gaber El-Saber Batiha7Bikash Karmakar8Department of Cardiothoracic Surgery, 3201 Hospital, Hanzhong 723000, ChinaDepartment of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi ArabiaDepartment of Chemistry, College of Science, University of Jeddah, P.O. Box 80327, Jeddah 21589, Saudi ArabiaDepartment of Chemistry, College of Sciences & Arts, King Abdulaziz University, Rabigh, Saudi ArabiaBiology Department, College of Science, King Khalid University, Abha, Saudi Arabia; Zoology Department, College of Science, Damanhour University, Damanhour, EgyptClinical Nutrition Department, Applied Medical Sciences College, Jazan University, Jazan 82817, Saudi ArabiaClinical Nutrition Department, General Directorate of Health Affairs, Jazan 82611, Saudi ArabiaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, AlBeheira, EgyptDepartment of Chemistry, Gobardanga Hindu College, 24 Parganas (North), India; Corresponding author.In this study, silver nanoparticles (Ag NPs) were decorated on the surface of magnetic nanoparticles in an eco-friendly pathway applying Mentha extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepared Ag/Fe3O4nanocomposite were determined using several advanced techniques. Hence, our protocol is green and advantageous in terms of- i) biochemical modified biocompatible nanocomposite; ii) nanomaterial providing high surface area and larger number reactive sites; iii) very simplistic synthetic procedure; vi) very low load of metal in the composite and v) high yield in short time. In the medicinal part, the anticancer properties of Ag/Fe3O4 nanocomposite against lung cancer cell lines were determined. The free radical for the antioxidant effects was DPPH. The IC50 of Ag/Fe3O4 nanocomposite was 200 µg/ml in the antioxidant test. The IC50 of the Ag/Fe3O4 nanocomposite were 183, 176, 169, and 125 µg/mL against lung cancer (NCI-H661, NCI-H1975, NCI-H1573, and NCI-H1563) cell lines, respectively. In addition, the current study offer that Ag/Fe3O4 nanocomposite could be a new potential adjuvant chemopreventive and chemotherapeutic agent against cytotoxic cells.http://www.sciencedirect.com/science/article/pii/S1319610322000874Ag nanoparticlesMagnetic nanocompositeGreen synthesisLung cancerChemotherapeutic supplement |
| spellingShingle | Tao Huang Huda S. AlSalem Mona Saad Binkadem Soha Talal Al-Goul Attalla F. El-kott Abdulrahman A. Alsayegh Ghawi J. Majdou Gaber El-Saber Batiha Bikash Karmakar Green synthesis of Ag/Fe3O4 nanoparticles using Mentha extract: Preparation, characterization and investigation of its anti-human lung cancer application Journal of Saudi Chemical Society Ag nanoparticles Magnetic nanocomposite Green synthesis Lung cancer Chemotherapeutic supplement |
| title | Green synthesis of Ag/Fe3O4 nanoparticles using Mentha extract: Preparation, characterization and investigation of its anti-human lung cancer application |
| title_full | Green synthesis of Ag/Fe3O4 nanoparticles using Mentha extract: Preparation, characterization and investigation of its anti-human lung cancer application |
| title_fullStr | Green synthesis of Ag/Fe3O4 nanoparticles using Mentha extract: Preparation, characterization and investigation of its anti-human lung cancer application |
| title_full_unstemmed | Green synthesis of Ag/Fe3O4 nanoparticles using Mentha extract: Preparation, characterization and investigation of its anti-human lung cancer application |
| title_short | Green synthesis of Ag/Fe3O4 nanoparticles using Mentha extract: Preparation, characterization and investigation of its anti-human lung cancer application |
| title_sort | green synthesis of ag fe3o4 nanoparticles using mentha extract preparation characterization and investigation of its anti human lung cancer application |
| topic | Ag nanoparticles Magnetic nanocomposite Green synthesis Lung cancer Chemotherapeutic supplement |
| url | http://www.sciencedirect.com/science/article/pii/S1319610322000874 |
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