Analysis of Inflammatory Mediators in Type 2 Diabetes Patients
The main aim of this study is to assess the inflammatory markers in type 2 diabetes mellitus (T2DM) by measuring some cytokines concentrations and lymphocytes subset and correlate them with other laboratory investigations....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/976810 |
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| author | Ahmed Al-Shukaili Saif AL-Ghafri Safia Al-Marhoobi Said Al-Abri Jawad Al-Lawati Masoud Al-Maskari |
| author_facet | Ahmed Al-Shukaili Saif AL-Ghafri Safia Al-Marhoobi Said Al-Abri Jawad Al-Lawati Masoud Al-Maskari |
| author_sort | Ahmed Al-Shukaili |
| collection | DOAJ |
| description | The main aim of this study is to assess
the inflammatory markers in type 2 diabetes mellitus (T2DM)
by measuring some cytokines concentrations and lymphocytes
subset and correlate them with other laboratory investigations.
Fifty-seven patients with type-2 diabetes and 30 healthy
volunteers were enrolled in this study. Data for the
C-reactive protein (CRP), haemoglobin, HbA1c,
and autoantibody levels were obtained from the patients files.
The cytokine concentrations were measured in patient’s serum
using commercially available ELISA assays. Lymphocytes subsets
were measured by flow cytometric methods.
The levels of IL-1β, IL-6, IL-15,
and TNF-α were found to be
decreased in T2DM patients, whereas the levels of IL-10,
IFN-γ, and caspase-1
were increased, compared to normal controls. T2DM patients with
hypertension show significantly decreased levels
of IL-1β and caspase-1
compared to patients without hypertension. No significant differences in
lymphocytes subset between cases and normal control were observed.
Significant correlations were found between HbA1c and IL-6; body mass
index (BMI) was significantly correlated with CRP,
TNF-α, and phosphate;
the weight (Wt) was associated with CRP and
IFN-γ. In conclusion, an
alteration in the function of the immune system was observed in T2DM patient. |
| format | Article |
| id | doaj-art-aa7404aa5d6042ad9bc14f96b82d1ff5 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-aa7404aa5d6042ad9bc14f96b82d1ff52025-08-20T02:20:54ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/976810976810Analysis of Inflammatory Mediators in Type 2 Diabetes PatientsAhmed Al-Shukaili0Saif AL-Ghafri1Safia Al-Marhoobi2Said Al-Abri3Jawad Al-Lawati4Masoud Al-Maskari5Health & Social Development Sector, The Research Council of Oman, P.O. Box 1422, 130 Muscat, OmanEmergency Departments, Sultan Qaboos University Hospital (SQUH), P.O. Box 35, 123 Muscat, OmanStudies & Planning, Statistics Section, The Research Council, P.O. Box 1422, 130 Muscat, OmanPublic Health, Armed Forces Medical Services Headquarters, Ministry of Defense, P.O. Box 928, 13 Muscat, OmanDepartment of Non-Communicable Diseases Surveillance and Control, Ministry of Health, P.O. Box 393, 100 Muscat, OmanEmergency Departments, Sultan Qaboos University Hospital (SQUH), P.O. Box 35, 123 Muscat, OmanThe main aim of this study is to assess the inflammatory markers in type 2 diabetes mellitus (T2DM) by measuring some cytokines concentrations and lymphocytes subset and correlate them with other laboratory investigations. Fifty-seven patients with type-2 diabetes and 30 healthy volunteers were enrolled in this study. Data for the C-reactive protein (CRP), haemoglobin, HbA1c, and autoantibody levels were obtained from the patients files. The cytokine concentrations were measured in patient’s serum using commercially available ELISA assays. Lymphocytes subsets were measured by flow cytometric methods. The levels of IL-1β, IL-6, IL-15, and TNF-α were found to be decreased in T2DM patients, whereas the levels of IL-10, IFN-γ, and caspase-1 were increased, compared to normal controls. T2DM patients with hypertension show significantly decreased levels of IL-1β and caspase-1 compared to patients without hypertension. No significant differences in lymphocytes subset between cases and normal control were observed. Significant correlations were found between HbA1c and IL-6; body mass index (BMI) was significantly correlated with CRP, TNF-α, and phosphate; the weight (Wt) was associated with CRP and IFN-γ. In conclusion, an alteration in the function of the immune system was observed in T2DM patient.http://dx.doi.org/10.1155/2013/976810 |
| spellingShingle | Ahmed Al-Shukaili Saif AL-Ghafri Safia Al-Marhoobi Said Al-Abri Jawad Al-Lawati Masoud Al-Maskari Analysis of Inflammatory Mediators in Type 2 Diabetes Patients International Journal of Endocrinology |
| title | Analysis of Inflammatory Mediators in Type 2 Diabetes Patients |
| title_full | Analysis of Inflammatory Mediators in Type 2 Diabetes Patients |
| title_fullStr | Analysis of Inflammatory Mediators in Type 2 Diabetes Patients |
| title_full_unstemmed | Analysis of Inflammatory Mediators in Type 2 Diabetes Patients |
| title_short | Analysis of Inflammatory Mediators in Type 2 Diabetes Patients |
| title_sort | analysis of inflammatory mediators in type 2 diabetes patients |
| url | http://dx.doi.org/10.1155/2013/976810 |
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