Inflammation alters myeloid cell and oligodendroglial iron-handling in multiple sclerosis

Inflammation alters myeloid cell and oligodendroglial iron-handling in multiple sclerosis

Abstract Changes in brain iron levels are a consistent feature of multiple sclerosis (MS) over its disease course. They encompass iron loss in oligodendrocytes in myelinated brain regions and iron accumulation in myeloid cells at so-called paramagnetic rims of chronic active lesions. Here, we explor...

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Bibliographic Details
Main Authors: Christian J. Riedl, Daniel Bormann, Anja Steinmaurer, Anja Novak, Giulia Testa, Elena Poldlehner, Carmen Haider, Thomas Berger, Michael Mildner, Romana Höftberger, Ferdinand Schweser, Simon Hametner
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Acta Neuropathologica Communications
Subjects:
Iron loss
Iron rim lesions
Multiple sclerosis
Oligodendrocytes
Microglia
Online Access:https://doi.org/10.1186/s40478-025-02020-0
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